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ethyl 4-amino-6-chloronicotinate

Product Name
ethyl 4-amino-6-chloronicotinate
CAS No.
380626-81-3
Chemical Name
ethyl 4-amino-6-chloronicotinate
Synonyms
ethyl 4-amino-6-chloronicotite;ethyl 4-amino-6-chloronicotinate;4-aMino-6-chloro Nicotinic acid ethyl;ethyl 4-aMino-6-chloropyridine-3-carboxylate;4-aMino-6-chloropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-aMino-6-chloro-, ethyl ester
CBNumber
CB82047759
Molecular Formula
C8H9ClN2O2
Formula Weight
200.62
MOL File
380626-81-3.mol
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ethyl 4-amino-6-chloronicotinate Property

Boiling point:
335.8±37.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.75±0.42(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C8H9ClN2O2/c1-2-13-8(12)5-4-11-7(9)3-6(5)10/h3-4H,2H2,1H3,(H2,10,11)
InChIKey
OAQIVHCEAFDMTK-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(N)=C1C(OCC)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
E899940
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
50mg
Price
$130
Updated
2021/12/16
TRC
Product number
E899940
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
100mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
250mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
100mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
1g
Price
$266
Updated
2021/12/16
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ethyl 4-amino-6-chloronicotinate Chemical Properties,Usage,Production

Uses

Ethyl 4-Amino-6-chloronicotinate is a useful reagent in the preparation of biologically active small molecules with pharmaceutical application.

Synthesis

1588423-42-0

380626-81-3

Ethyl 6-chloro-4-((2,4-dimethoxybenzyl)amino)nicotinate (15 g, 42.8 mmol) was used as a raw material, which was mixed with trifluoroacetic acid (TFA, 80 mL), heated to 50 °C and the reaction was maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed under reduced pressure. The pH of the residue was adjusted to 8 with aqueous sodium bicarbonate (NaHCO3) and then extracted with ethyl acetate (EtOAc). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=4:1) to afford the target product ethyl 4-amino-6-chloronicotinate (5.1 g, 61% yield) as a white solid.

References

[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 218
[2] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 180-181

ethyl 4-amino-6-chloronicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-amino-6-chloronicotinate Suppliers

China 100 India 1 The Netherlands 1 United States 6 Global 108
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from ethyl 4-amino-6-chloronicotinate manufacturers

Career Henan Chemical Co
Product
ethyl 4-amino-6-chloronicotinate 380626-81-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1ton
Release date
2020-01-08
Career Henan Chemical Co
Product
ethyl 4-amino-6-chloronicotinate 380626-81-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

380626-81-3, ethyl 4-amino-6-chloronicotinateRelated Search:

Ethyl 5-broMo-6-chloropicolinate 3-Pyridinecarboxylic acid, 4-chloro-6-nitro-, ethyl ester Ethyl 6-chloro-2,4-diMethylnicotinate 4-Pyridinecarboxylic acid, 5-hydroxy-2-methyl-, ethyl ester Ethyl 6-broMo-2-chloronicotinate 3-Pyridinecarboxylic acid, 5-chloro-1,6-dihydro-1-methyl-6-oxo-, ethyl ester 5-Bromo-3-methylpyridine-2-carboxylic acid ethyl ester ethyl 5-chloro-3-fluoropicolinate Ethyl 5-bromo-2-chloroisonicotinate 2-Pyridinecarboxylic acid, 6-chloro-3-fluoro-, ethyl ester Ethyl 5-bromo-4,6-dichloronicotinate ethyl 4-cyano-2-pyridinecarboxylate ethyl 4-chloro-2-Methylnicotinate 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-

  • 4-aMino-6-chloropyridine-3-carboxylic acid ethyl ester
  • 4-aMino-6-chloro Nicotinic acid ethyl
  • 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-, ethyl ester
  • ethyl 4-aMino-6-chloropyridine-3-carboxylate
  • ethyl 4-amino-6-chloronicotinate
  • ethyl 4-amino-6-chloronicotite
  • 380626-81-3