Summary Preparation Pharmacological action Uses Adverse reaction Precautions Production
ChemicalBook > CAS DataBase List > Magnesium trisilicate

Magnesium trisilicate

Summary Preparation Pharmacological action Uses Adverse reaction Precautions Production
Product Name
Magnesium trisilicate
CAS No.
14987-04-3
Chemical Name
Magnesium trisilicate
Synonyms
dimagnesium trisilicon octaoxide;petimin;magnosil;三硅酸镁生产厂家;meerschaum;dicarbocalm;Trisilicalm;parasepiolite;nesium trisiL;Sanguisuanmei
CBNumber
CB8205317
Molecular Formula
H8MgOSi
Formula Weight
76.45
MOL File
14987-04-3.mol
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Magnesium trisilicate Property

RTECS 
IN6620000
solubility 
Practically insoluble in water and in ethanol (96 per cent).
form 
Powder
color 
White
Water Solubility 
insoluble H2O, EtOH [CRC10]
Merck 
14,5687
CAS DataBase Reference
14987-04-3(CAS DataBase Reference)
EPA Substance Registry System
Magnesium silicon oxide (Mg2Si3O8) (14987-04-3)
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Safety

WGK Germany 
3
TSCA 
Yes
Hazardous Substances Data
14987-04-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
033338
Product name
Magnesium trisilicate
Packaging
250g
Price
$48.9
Updated
2024/03/01
Alfa Aesar
Product number
033338
Product name
Magnesium trisilicate
Packaging
1kg
Price
$76.9
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
ING0004462
Product name
MAGNESIUM TRISILICATE
Purity
95.00%
Packaging
1KG
Price
$6736.22
Updated
2021/12/16
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Magnesium trisilicate Chemical Properties,Usage,Production

Summary

Magnesium trisilicate is also known as “magnesium orthosilicate”. The chemical formula is Mg2Si3O8•nH2O and white orthorhombic crystal with melting point of 1910℃ and relative density of 3.21. This product is insoluble in water or ethanol. It is decomposed into Mg(OH)2 in concentrated alkali or decomposed into silicic acid and magnesium chloride in hot hydrochloric acid. It can be decomposed by hydrofluoric acid. It exists as forsterite mineral in nature. Due to the openness of its crystal structure, it contains holes and channels which are connected with each other as well as the outside world, and has a more developed pore structure and a large specific surface area, thus it has better adsorption performances and molecular sieve functions, which can provide specific acting force of the molecular field. In medicine, it has a lesser effect on neutralizing gastric acid, but slow and lasting, up to 4~5 hours. It is suitable for the treatments of stomach and duodenal ulcer. It also can relieve symptoms caused by hyperacidity. In addition, it can be used as processing aid or polyether adsorbent, which has the function of adsorption and decolorization. The product has broad application prospects in the pharmaceutical intermediates, food additives, rubber filling agent, deodorant, ceramic industry, and other fields. 

Preparation

A certain concentration of Na2O•nSiO2 solution and Mg(NO3)2 solution are respectively prepared by using sodium silicate with chemically pure modulus of 3.34 and chemically pure Mg(NO3)2 as raw materials. According to n(Si):n(Mg)=2:1, Mg(NO3)2 solution is dripped into Na2O•nSiO2 solution at a speed of 5 ml /min and stirred at the same time with the appearance of white precipitate. The mixture solution is aged after 1.0h’s standing after dropping. Then this product can be obtained through preparation of filtering, washing, precipitating to a neutral stance and oven drying.

Pharmacological action

The product is antacid with slow and long-lasting effect, it does not produce any gas thus protecting the gastric mucosa, and it has the function of light diarrhea and adsorption. Insoluble in water. It can absorb the free acid in stomach, so it plays the role of making acid. The function of neutralizing peptic acid is weak, slow but long-lasting, up to 4~5 hours. The hypocatharsis of antacids containing magnesium can lead to defecation. About 10 % of magnesium can be absorbed by the intestine. In the process of neutralizing gastric acid, there is no carbon dioxide but colloidal silica, which is covered on the surface of ulcer and has protective effects. It can also absorb enterotoxins, bacteria and harmful gases. Large doses have the function of light diarrhea. It is clinically used for hyperacidity and peptic ulcer.

Uses

It is used medicinally as an antacid. It can neutralize the stomach acid and protect the ulcer with slow and lasting effects, up to 4~5 hours. It does not produce the gas to protect the gastric mucosa, and it has the function of light diarrhea and adsorption. It can be used to treat stomach, duodenal ulcer and relieve symptoms caused by hyperacidity. It can be used as antioxidant, deodorizer, decolorizer, TLC adsorbent, column chromatography adsorbent and so. It can also be used in ceramics and rubber industry. Food grade products are used as anti-caking agent, filter aid and film agent. According to regulations formulated by FAO / WHO (1984), the maximum amount of anti-caking agent used in powdered dairy products ( milk powder, cream powder, high fat milk powder and half cream powder ) is 10 g / kg.

Adverse reaction

Long-term use of this product may cause renal tubular silicon stones, thereby damaging the renal tubules. Therefore, in the treatment of gastric ulcer, its potential toxicity should be noted. Vertigo, convulsions, arrhythmia, mental symptoms and abnormal fatigue may occur in patients with renal insufficiency or a large number of long-term use.

Precautions

  1. It is contraindicated in patients allergic to the product.
  2. It is not recommended for children.
  3. It should be carefully used during the first three months of pregnancy.
  4. When combined with atropine, digoxin, diazepam and isoniazid, it may affect curative effect of the latter due to the decrease of absorption. When combined with levodopa, the absorption may increase; chlorpromazine drugs can inhibit the absorption of this product.

Production

In the complex decomposition method, the reaction is used to produce magnesium trisilicate precipitation after the pretreatment of magnesium sulfate and magnesium sulfate. Then the finished product of magnesium trisilicate is prepared through washing, filter pressing, drying and crushing. As follows:
2Na2O•3SiO2•5H2O+2MgSO4→Product+2Na2SO4

Chemical Properties

White or almost white powder.

Chemical Properties

The USP 32 describes magnesium trisilicate as a compound of magnesium oxide and silicon dioxide with varying proportions of water. It contains not less than 20.0% of magnesium oxide and not less than 45.0% of silicon dioxide. The PhEur 6.0 similarly describes magnesium trisilicate as having a variable composition corresponding to the approximate formula Mg2Si3O8·xH2O. It contains not less than 29.0% of magnesium oxide and not less than the equivalent of 65.0% of silicon dioxide, both calculated with reference to the ignited substance.
Magnesium trisilicate occurs as an odorless and tasteless, fine, white-colored powder that is free from grittiness.

Uses

Industrial odor absorbent, decolorizing agent, antioxidant, medicine (antacid).

Definition

USP specifies not less than 20% magnesium oxide and 45% SiO2, similar to the FCC requirements for magnesium silicate. See talc.

Production Methods

Magnesium trisilicate may be prepared from sodium silicate and magnesium sulfate. It also occurs in nature as the minerals meerschaum, parasepiolite, and sepiolite.

brand name

Trimax (Sterling Winthrop).

Pharmaceutical Applications

Magnesium trisilicate is used in oral pharmaceutical formulations and food products as a glidant. It is also used therapeutically as an antacid, and also for the treatment of ciprofloxacin overdose or toxicity.

Pharmaceutical Applications

Magnesium trisilicate (Mg2Si3O8) can be used in antacid preparations especially in the treatment of peptic ulcers. The mode of action includes the increase of the pH of the gastric fluid together with the formation of a colloidal silica precipitate,which forms a protection for theGImucosa. Magnesium trisilicate reduces the absorption of iron products, certain antibiotics (such as Nitrofurantoin) or antimalarial drugs (such as Proguanil).

Safety

Magnesium trisilicate is used in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material.
When administered orally, magnesium trisilicate is neutralized in the stomach to form magnesium chloride and silicon dioxide; some magnesium may be absorbed. Caution should be used when concentrations greater than 50 mEq of magnesium are given daily to persons with impaired renal function, owing to the risk of hypermagnesemia.
Therapeutically, up to about 2 g of magnesium trisilicate may be taken daily as an antacid. Reported adverse effects include the potential for osmotic diarrhea in the elderly using antacids containing magnesium trisilicate;and the potential for the formation of bladder and renal calculi following the long-term use of magnesium trisilicate as an antacid.

storage

Magnesium trisilicate is stable if stored in a well-closed container in a cool, dry place.

Incompatibilities

Magnesium trisilicate, when taken with drugs such as mebeverine hydrochloride,proguanil,norfloxacin,sucralfate, and tetracycline, may cause a reduction in bioavailability via binding or chelation. The dissolution rate of folic acid, erythromycin stearate,paracetamol, and chloroquine phosphate may be retarded by adsorption onto magnesium trisilicate. Antimicrobial preservatives, such as the parabens, may be inactivated by the addition of magnesium trisilicate.
Magnesium trisilicate is also readily decomposed by mineral acids.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Magnesium trisilicate Preparation Products And Raw materials

Raw materials

Preparation Products

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Magnesium trisilicate Suppliers

Guangzhou Jicheng Import and Export Trading Co.,Ltd
Tel
13682223272
Email
173901442@qq.com
Country
China
ProdList
479
Advantage
58
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD
Tel
020-37651955 13682223272
Fax
020-87659730
Email
173901442@qq.com
Country
China
ProdList
694
Advantage
58
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Magnesium trisilicate manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
Magnesium trisilicate 14987-04-3
Price
US $9.90-7.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-28
Hebei Weibang Biotechnology Co., Ltd
Product
Magnesium trisilicate 14987-04-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-16
Shaanxi Dideu Medichem Co. Ltd
Product
Magnesium trisilicate 14987-04-3
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30

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