Overview Biosynthesis Physiological function Applications Toxicity The effect of putrescine on food quality Reference
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1,4-DIAMINOBUTANE

Overview Biosynthesis Physiological function Applications Toxicity The effect of putrescine on food quality Reference
Product Name
1,4-DIAMINOBUTANE
CAS No.
110-60-1
Chemical Name
1,4-DIAMINOBUTANE
Synonyms
DAB;PUTRESCINE;BUTANE-1,4-DIAMINE;1,4-BUTANEDIAMINE;DiaMinobutane;butanediamine;1,4-Butylenediamine;TETRAMETHYLENEDIAMINE;PUTRESCIN;Butylene-1,4-diamine
CBNumber
CB8210315
Molecular Formula
C4H12N2
Formula Weight
88.15
MOL File
110-60-1.mol
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1,4-DIAMINOBUTANE Property

Melting point:
27 °C
Boiling point:
158-160 °C(lit.)
Density 
0.877 g/mL at 25 °C(lit.)
vapor pressure 
436 Pa (25 °C)
refractive index 
n20/D 1.457(lit.)
Flash point:
125 °F
storage temp. 
Store below +30°C.
solubility 
cell culture medium: 0.16 mg/mL
form 
lyophilized powder
pka
10.8(at 20℃)
Specific Gravity
0.877
color 
Clear colorless to slightly yellow
Odor
animal rotting fish
explosive limit
0.7-11.2%(V)
Water Solubility 
almost transparency
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,7947
BRN 
605282
Stability:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. Flammable.
LogP
-0.84 at 25℃ and pH10.45-11.86
Dissociation constant
9.35-10.8 at 25℃
CAS DataBase Reference
110-60-1(CAS DataBase Reference)
EPA Substance Registry System
1,4-Butanediamine (110-60-1)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-21/22-23-34-10
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 2928 6.1/PG 2
WGK Germany 
3
RTECS 
EJ6800000
F 
3-10-23-34
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29212900
Hazardous Substances Data
110-60-1(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 463 mg/kg LD50 dermal Rabbit 1576 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D13208
Product name
1,4-Diaminobutane
Purity
99%
Packaging
25g
Price
$37.9
Updated
2024/03/01
Sigma-Aldrich
Product number
51799
Product name
Putrescine
Purity
analytical standard
Packaging
100mg
Price
$73.6
Updated
2024/03/01
TCI Chemical
Product number
D0239
Product name
1,4-Diaminobutane
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
D0239
Product name
1,4-Diaminobutane
Purity
>98.0%(GC)(T)
Packaging
400g
Price
$152
Updated
2024/03/01
Alfa Aesar
Product number
B21316
Product name
1,4-Diaminobutane, 98+%
Packaging
25g
Price
$41.2
Updated
2024/03/01
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1,4-DIAMINOBUTANE Chemical Properties,Usage,Production

Overview

Putrescine is a low-molecular-weight nitrogenous base with the systematic name 1,4-diaminobutane. It is an aliphatic diamine belonging to the group of biogenic amines (Bas). Two basic amino groups are present, which at the physiological pH of 7.4 carry a positive charge that makes them suitable for a wide range of functions in different cell types. According to some authors, putrescine also belongs, together with cadaverine, spermine, and spermidine, to polyamines (molecules containing two or more amino groups in the molecule)[1,2]. Polyamines are found in all cell types and their presence in various kinds of foodstuffs is partly due to their endogenous origin. In humans, there are 3 common sources of putrescine: the first one is endogenous biosynthesis within their own cells, the second one includes foodstuffs (alimentary intake), and the last one is the production of putrescine by bacteria of the intestinal microflora. The largest amount of putrescine in humans is taken from food[2]. If none of the 3 sources of putrescine becomes excessive, putrescine is used for its physiological functions and the excess is excreted by normal metabolism. However, increased intake of putrescine in food can lead to serious toxicological consequences.

Figure 1 The chemical structure of putrescine

Biosynthesis

l ,4-Diaminobutane (putrescine), spermidine, spermine, and closely related derivatives are found in a wide variety of animals, bacteria, yeasts, and plants. It is generally accepted that polyamine biosynthesis is intimately interrelated with the synthesis of nucleic acids and proteins[3]. Polyamines are ubiquitous in biological materials, although the relative amounts of 1,4-diaminobutane, spermidine, and spermine differ markedly in different cells[4, 5]. In general, prokaryotes have a higher concentration of 1,4-diaminobutane than spermidine and lack spermine. Eukaryotes usually have little 1,4-diaminobutane, and have spermine as well as spermidine.
The pathway for the biosynthesis of 1,4-diaminobutane and spermidine was first established in microorganisms and was later found to be very similar in animal cells. In bacteria, 1,4-diaminobutane may be formed either by ornithine decarboxylase or by arginine decarboxylase via agmatine[6-8]. Both biosynthetic enzymes are normally present in Escherichia coli, although ornithine decarboxylation is usually the major pathway[8]. Both decarboxylases have been purified from E. coli and have been shown to require pyridoxal phosphate[9-11]. These enzymes are subject to feedback inhibition and repression by 1,4-diaminobutane or spermidine[12, 13]. In animal tissues amines are derived by decarboxylation of ornithine, rather than by decarboxylation of arginine[14, 15]. Purification of ornithine decarboxylase has been hindered by the very low enzyme activity normally present. However, as discussed in the section on the role of polyamines in growth, ornithine decarboxylase levels increase dramatically after a variety of stimuli, and the enzyme has been purified to apparent homogeneity from regenerating liver[17] and from the livers of rats treated with thioacetamide[18]. Pyridoxal phosphate appears to be a required cofactor[16, 19].

Physiological function

Putrescine fulfills important physiological functions in a wide variety of living cells. This BA shows many physiological functions and it is a precursor in the synthesis of other polyamines (spermine and spermidine). Putrescine is classified as a physiologic amine. Physiological functions of putrescine and other polyamines are related to their polycationic nature, which determines interactions with negatively charged molecules such as DNA, RNA, proteins, phospholipids[20]. Newer studies show that putrescine, along with other polyamines and phosphate ions, forms nuclear aggregates of polyamines in the cell nuclei, which are responsible for the abovementioned interactions and affect the 3-dimensional structure of DNA[21]. These interactions are related to the regulation of the structure of nucleic acids and protein synthesis[22, 23].
Putrescine, along with other polyamines, binds to membrane structures such as phospholipids, mainly in erythrocytes. This polyamine may lead to a decrease in membrane fluidity but also to increased resistance to fragmentation due to stabilization of the membrane skeleton[24, 25]. It has also been found that apart from the membrane stabilization and the effect on the synthesis of nucleic acids and proteins, polyamines are involved in the removal of free radicals[26]. In many mammals, they play an important role as luminal growth factors for intestinal maturation and growth[27, 28] and can play a significant role in the prevention of food allergies[29]. In mammals, polyamines have direct effects on several ion channels and receptors, resulting in the regulation of Ca2+, Na+, and K+ homeostasis[30, 31].

Applications

Putrescine is used as a precursor in many biological systems and synthon for amido-ureas. It is involved in the synthesis of nylon 46 by reacting with adipic acid[32].

Toxicity

With respect to important physiological functions, it is clear that disruption of the normal balance due to increased intake of putrescine from food can have serious toxicological consequences. Although the toxic effects of putrescine are significantly lower than that of histamine or tyramine, there are many serious secondary effects. Diamines such as putrescine have a very important role in alimentary poisoning as they can enhance and potentiate the toxic effect of histamine, tyramine, and phenylethylamine by interacting with enzymes that metabolize these BAs[33]. For example, experiments on guinea pigs and rats revealed that putrescine potentiates histamine toxicity up to 10 times[34, 35]. Putrescine enhances histamine toxicity by inhibiting enzymes oxidizing histamine diaminooxidase(DAO; EC 1.4.3.6) and histamine N-methyltransferase (NMT; EC 2.1.1.8)[36-38]. Moreover, from a toxicological point of view, a serious aspect of putrescine occurrence in foodstuffs is the possibility of forming carcinogenic nitrosamines. Putrescine can form carcinogenic nitrosamines by the reaction with nitrites[39, 40].

The effect of putrescine on food quality

In addition to the toxic effects, the occurrence of putrescine in foodstuffs leads to undesirable organoleptic properties and adversely affects the taste and aroma of food[41], for example, in shrimps, it is perceptible at concentrations of 3 mg/kg[42]. Increased occurrence of putrescine indicates food spoilage caused by microbial activity and it is also the main BA that indicates spoiled meat. The amount of putrescine, histamine, and cadaverine shows the freshness of meat and is defined as biogenic amines index (BAI)[43].

Reference

  1. Smith TA. 1981. Amines in food. Food Chem 6[3]:169–200.
  2. Bard´ocz S, Duguid TJ, Brown DS, Grant G, Pusztai A, White A, Ralph A. 1995. The importance of dietary polyamines in cell regeneration and growth. Br J Nutr 73[6]:819–28.
  3. Guggenheim, M. 1 9 5 1 . Die biogenell Amine. Switzerland: Karger. 4th ed.
  4. Tabor, H., Tabor, C. W. 1964. Pharmacal. Rev. 1 6:245-300
  5. Tabor, H., Tabor, C. W. 1972. Adv. Enzymol. 36:203-68
  6. Morris, D. R., Fillingame, R. H. 1974. Ann. Rev. Biochem. 43:303-25
  7. Morris, D. R., Pardee, A. B. 1966. J. Bio. Chem. 241:3 129-35
  8. Morris, D. R., Koffron, K. L. 1969. J. Bio. Chem. 244:6094-99
  9. Applebaum, D. 1972. Purification and characterization of induced and biosynthetic ornithine decarboxylases of Escherichia coli. PhD thesis. Univ. Washington. Seattle. 157 pp. Univ. Microfilms #73-1 3789
  10. Wu, W. H., Morris, D. R. 1973. J. Bio. Chem. 248: 1687-95, 1696-99
  11. Holtta, E., Janne, J., Pispa, J. 1972. Biochem. Biophys. Res. Commun. 47: 1165-71
  12. Tabor, H., Tabor. C. W. 1969. J. Bio. Chem. 244:2286-92
  13. Morris, D. R., Wu, W. H., Applebaum, D., Kofi'ron, K. L. 1970. See Ref. 8, pp. 968-76
  14. Russell, D. H., cd. 1973. Polyamines in Normal and Neoplastic Growth, New York: Raven. 429 pp.
  15. Herbst, E. J., Bachrach, U.,cds. 1970. Ann. NY Acad. Sci. 171:693-1009
  16. Pegg. A. E . . Williams-Ashman. H. G. 1968. Biochem. J 108: 533-39
  17. Friedman, S. J., Halpern, K. Y., Canellakis, E. S. 1972. Biochim. Biophys. Acta 261:181-87
  18. Ono, M., Inoue, H., Suzuki, F., Takeda, Y. 1972. Biochim. Biophys. Acta 284:285-97
  19. Raina, A., Jiinne, J. 1968. Acta Chem. Scand. 22 :2375-77
  20. Igarashi K, Kashiwagi K. 2010. Modulation of cellular function by polyamines. Intl J Biochem Cell Biol 42[1]:39–51.
  21. Di Luccia A, Picariello G, Iacomino G, Formisano A, Paduano L, D’Agostino L. 2009. The in vitro nuclear aggregates of polyamines. FEBS J 276[8]:2324–35.
  22. Silla Santos MH. 1996. Biogenic amines: their importance in foods. Intl J Food Microbiol 29[2–3]:213–31.
  23. Hou MH, Lin SB, Yuann JM, Lin WC, Wang AH, Kan Ls L. 2001. Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure. Nucleic Acids Res 29[24]:5121–8.
  24. Til HP, Falke HE, Prinsen MK, Willems MI. 1997. Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats. Food Chem Toxicol 35[3–4]:337–48.
  25. Largue E, Sabater-Molina M, Zamora S. 2007. Biological significance of dietary polyamines. Nutrition 23[1]:87–95.
  26. Kaur-Sawhney R, Tiburcio AF, Altabella T, Galston AW. 2003. Polyamines in plants: an overview. J Cell Mol Biol 2:1–12.
  27. Dufour C, Dandrifosse G, Forget P, Vermesse F, Romain N, Lepoint P. 1988. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology 95[1]:112–6.
  28. L¨oser C. 2000. Polyamines in human and animal milk. Br J Nutr 84[Suppl1]:S55–8 Dandrifosse G, Peulen O, El Khefif N, Deloyer P, Dandrifosse AC, Grandfils C. 2000. Are milk polyamines preventive agents against food allergy? Proc Nutr Soc 59[1]:81–6.
  29. Dandrifosse G, Peulen O, El Khefif N, Deloyer P, Dandrifosse AC, Grandfils C. 2000. Are milk polyamines preventive agents against food allergy? Proc Nutr Soc 59[1]:81–6.
  30. Johnson TD. 1996. Modulation of channel function by polyamines. Trends Pharmacol Sci 17[1]:22–7.
  31. Li J, Doyle KM, Tatlisumak T. 2007. Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischemia. Curr Med Chem 14[17]:1807–
  32. https://www.alfa.com/zh-cn/catalog/B21316/
  33. Taylor SL. 1985a. Histamine food poisoning: toxicology and clinical aspects. Crit Rev Toxicol 17[2]:91–128.
  34. Parrot J, Nicot G. 1966. Pharmacology of histamine. In: Eichler O, Farah S, editors. Handbook of experimental pharmacology. Heidelberg: Springer-Verlag. p 148–61.
  35. Lehane L, Olley J. 2000. Histamine fish poisoning revisited. Intl J Food Microbiol 58[1–2]:1–37.
  36. Stratton JE, Hutkins RW, Taylor SL. 1991. Biogenic amines in cheese and other fermented foods: a review. J Food Prot 54[6]:460–70.
  37. Hern´andez-Jover T, Izquierdo-Pulido M, Veciana-Nogues MT, Marine-Font A, Vidal-Carou MC. 1997. Biogenic amine and polyamine contents in meat and meat products. J Agric Food Chem 45[6]:2098–102.
  38. Emborg J, Dalgaard P. 2006. Formation of histamine and biogenic amines in cold-smoked tuna: an investigation of psychrotolerant bacteria from samples implicated in cases of histamine fish poisoning. J Food Prot 69[4]:897–906.
  39. Shalaby AR. 1996. Significance of biogenic amines to food safety and human health. Food Res Intl 29[7]:675–90.
  40. Bover-Cid S, Holzapfel WH. 1999. Improved screening procedure for biogenic amine production by lactic acid bacteria. Intl J Food Microbiol 53[1]:33–41.
  41. Lehane L, Olley J. 2000. Histamine fish poisoning revisited. Intl J Food Microbiol 58[1–2]:1–37.
  42. Benner Jr RA, Staruszkiewicz WF, Rogers PL, Otwelle WS. 2003. Evaluation of putrescine, cadaverine, and indole as chemical indicators of decomposition in penaeid shrimp. J Food Sci 68[7]:2178–85.
  43. Karmas E. 1981. Biogenic amines as indicators of sea food freshness. Lebensmitt Wissensch Technol Food Sci Technol 14[5]:273–5.

Chemical Properties

colourless liquid

Uses

A GABA precursor in many biological systems.

Uses

1,4-Diaminobutane is used as a precursor in many biological systems and synthon for amido-ureas. It is involved in the synthesis of nylon 46 by reacting with adipic acid.

Uses

GABA precursor in many biological systems and synthon for amido-ureas.

Definition

ChEBI: A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.

Safety Profile

Poison by subcutaneous, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also 1,3-BUTANEDIAMINE and AMINES.

1,4-DIAMINOBUTANE Preparation Products And Raw materials

Raw materials

Phthalimide Calcium oxide N,N-Dimethylformamide Dimethylglyoxime 1,4-Dichlorobutane Hydrochloric acid Sodium hydroxide Sodium carbonate

Preparation Products

tert-Butyl N-(4-aminobutyl)carbamate Dimethachlon Spermidine Tetramethylpyrazine
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Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20810
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60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
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60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9951
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58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
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0755-23229476 QQ: 2355327139
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siliao02@yccreate.com
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China
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6120
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Guangzhou Kafen Biotech Co.,Ltd
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18029243487 2355327168
Fax
020-31121510
Email
gy@yccreate.com
Country
China
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4753
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55
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5175
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55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5176
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55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
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55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
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0539-6362799（To 20）
Country
China
ProdList
9998
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58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19806
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View Lastest Price from 1,4-DIAMINOBUTANE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
1,4-DIAMINOBUTANE 110-60-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Guanlang Biotechnology Co., Ltd.
Product
1,4-DIAMINOBUTANE 110-60-1
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,4-Diaminobutane 99% 110-60-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

110-60-1, 1,4-DIAMINOBUTANERelated Search:

1,4-Bis(dimethylamino)butane, N,N,Nμ,Nμ-Tetramethyl-1,4-diaminobutane 1,4,7,10,13-Pentaazatridecane 2,4,4,6-TETRABROMO-2,5-CYCLOHEXADIENONE Tetraethylene glycol dimethyl ether Nalpha-Cbz-L-Arginine 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE H-GAMMA-GLU-GLU-OH L(+)-Arginine STRYCHNINE DL-CITRULLINE 3-CARBAMOYL-PROXYL L-Glutamine SUCCINAMIDE 10,11-Dimethoxystrychnine N'-Nitro-L-arginine N-ALPHA-BENZOYL-L-ARGININE N-Boc-1,4-diaminobutane, tert-Butyl N-(4-aminobutyl)carbamate Tetramethylenediamine, N,N-diethyl-4-methyl-

  • 1,4-Butylenediamine
  • 1,4-Tetramethylenediamine
  • Butylene-1,4-diamine
  • H2N(CH2)4NH2
  • Tetramethyldiamine
  • 1,4-Butanediamine, Putrescine, Tetramethylenediamine
  • 1,4-Diaminobutane,99%
  • 1,4-DiaMinobutane, 99% 100GR
  • 1,4-DiaMinobutane, 99% 25GR
  • Putrescine 〔1,4-Diaminobutane〕
  • 1,4-Diaminobutane,1,4-Butanediamine, Putrescine, Tetramethylenediamine
  • 1.4Diaminobutane ACROS 5g(5.7ml)
  • 1,4-D diaMine
  • 1,4-DIAMINOBUTANE FOR SYNTHESIS
  • DiaMinobutane
  • 1,4-DiaMinobutane 99%
  • 1.4-DiaMinobut
  • RARECHEM AL BW 0068
  • PUTRESCIN
  • PUTRESCINE
  • TETRAMETHYLENEDIAMINE
  • 1,4-DIAMINOBUTANE
  • 14DAB
  • 1,4-BUTANEDIAMINE
  • BUTANE-1,4-DIAMINE
  • BUTYLENEDIAMINE
  • DAB
  • putrescine free base
  • 1,4-Butanediamine, putrescine
  • butanediamine
  • 1,4-Diaminobutane, Tetramethylenediamine, free base, 99%
  • 1,4-Diaminobutane, 98+%
  • 1,4-Diaminobutane&gt
  • 1,4-DIAMINOBUTANE ISO 9001：2015 REACH
  • Tetramethylendiamin
  • Putrescine free base extrapure, 99%
  • 110-60-1
  • 25ML/瓶[110-60-1
  • NH2CH24NH2
  • Monofunctional & 伪,蠅-Bifunctional Alkanes
  • 伪,蠅-Bifunctional Alkanes
  • 伪,蠅-Alkanediamines
  • Nitrogen Compounds
  • Organic Building Blocks
  • Polyamines
  • Building Blocks
  • Bioactive Small Molecules
  • Building Blocks
  • Cell Biology
  • Chemical Synthesis
  • D-DIF
  • Nitrogen Compounds
  • Organic Building Blocks
  • Polyamines
  • alpha,omega-Bifunctional Alkanes
  • Monofunctional & alpha,omega-Bifunctional Alkanes
  • alpha,omega-Alkanediamines
  • PROTAC LINKER