ChemicalBook > CAS DataBase List > Atrasentan hydrochloride

Atrasentan hydrochloride

Product Name: Atrasentan hydrochloride
CAS No.: 195733-43-8
Chemical Name: Atrasentan hydrochloride
Synonyms: ABT627;ABT 627;ABT-627;A 147627.1;Abbott 147627;Atrasentan HCl;Unii-E4G31X93za;ABT-627 hydrochloride;A-147627 hydrochloride;Atrasentan hydrochloride
CBNumber: CB82128704
Molecular Formula: C29H38N2O6.HCl
Formula Weight: 547.08
MOL File: 195733-43-8.mol

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Atrasentan hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: Powder
color: Off-white to gray
InChI: InChI=1/C29H38N2O6.ClH/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20;/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34);1H/t23-,27-,28+;/s3
InChIKey: IJFUJIFSUKPWCZ-FZVADPAUNA-N
SMILES: C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A793930
Product name: AtrasentanHydrochloride
Packaging: 25mg
Price: $825
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA64949
Product name: Atrasentan hydrochloride
Packaging: 5mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA64949
Product name: Atrasentan hydrochloride
Packaging: 10mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-1373
Product name: Atrasentan(hydrochloride)
Purity: 99.51%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: 0895CB
Product name: Atrasentanhydrochloride
Packaging: 5mg
Price: $277
Updated: 2021/12/16

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Atrasentan hydrochloride Chemical Properties,Usage,Production

Description

Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.

Uses

Atrasentan belongs to a pyrrolidine and benzodioxole derivative. It is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in the inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Its potential therapeutic uses include the treatment of diabetic nephropathies and as an antineoplastic agent.

Biological Activity

Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.

in vivo

Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats^[1]. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model^[2].

Atrasentan hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Atrasentan hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Atrasentan hydrochloride 195733-43-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-20

195733-43-8, Atrasentan hydrochlorideRelated Search:

1,4-Dioxane Benzo[a]pyrene Topotecan hydrochloride Tamsulosin hydrochloride Selenium dioxide Tamsulosin hydrochloride atrasentan DIOXOPROMETHAZINE Atrasentan hydrochloride

Atrasentan hydrochloride, CID 159595

ABT-627; ABT627; ABT 627; ABBOTT 147627

Atrasentan hydrochloride

Atrasentan hydrochloride (ABT-627

3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-

A 147627.1

Abbott 147627

Atrasentan HCl

Atrasentan hydrochloride [usan]

Unii-E4G31X93za

ABT 627

ABT627

ABT-627

3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-

(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride

ABT-627; ABT627; ABT 627

ABT-627 hydrochloride

(+)-A 127722 hydrochloride

A-147627 hydrochloride

(2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride

Atrasentan Hydrochloride，ABT627 HCl

A 147627,A-147627,(+)-A 127722,Atrasentan hydrochloride,Atrasentan,ABT627,ABT-627,Endothelin Receptor,ABT 627,Inhibitor,inhibit,A147627

Atrasentan hydrochloride, 10 mM in DMSO

195733-43-8

C29H38N2O6HCl

C29H39ClN2O6

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