Atrasentan hydrochloride
- Product Name
- Atrasentan hydrochloride
- CAS No.
- 195733-43-8
- Chemical Name
- Atrasentan hydrochloride
- Synonyms
- ABT627;ABT 627;ABT-627;A 147627.1;Abbott 147627;Atrasentan HCl;Unii-E4G31X93za;ABT-627 hydrochloride;A-147627 hydrochloride;Atrasentan hydrochloride
- CBNumber
- CB82128704
- Molecular Formula
- C29H38N2O6.HCl
- Formula Weight
- 547.08
- MOL File
- 195733-43-8.mol
Atrasentan hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- InChI
- InChI=1/C29H38N2O6.ClH/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20;/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34);1H/t23-,27-,28+;/s3
- InChIKey
- IJFUJIFSUKPWCZ-FZVADPAUNA-N
- SMILES
- C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A793930
- Product name
- AtrasentanHydrochloride
- Packaging
- 25mg
- Price
- $825
- Updated
- 2021/12/16
- Product number
- 0895CB
- Product name
- Atrasentanhydrochloride
- Packaging
- 50mg
- Price
- $937
- Updated
- 2021/12/16
- Product number
- FA64949
- Product name
- Atrasentan hydrochloride
- Packaging
- 100mg
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- CS-1373
- Product name
- Atrasentan(hydrochloride)
- Purity
- 99.51%
- Packaging
- 50mg
- Price
- $1087
- Updated
- 2021/12/16
- Product number
- 0895CB
- Product name
- Atrasentanhydrochloride
- Packaging
- 5mg
- Price
- $277
- Updated
- 2021/12/16
Atrasentan hydrochloride Chemical Properties,Usage,Production
Description
Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
Uses
Atrasentan belongs to a pyrrolidine and benzodioxole derivative. It is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in the inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Its potential therapeutic uses include the treatment of diabetic nephropathies and as an antineoplastic agent.
Biological Activity
Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.