3-Chloro-4-Fluorobenzyl Cyanide
- Product Name
- 3-Chloro-4-Fluorobenzyl Cyanide
- CAS No.
- 658-98-0
- Chemical Name
- 3-Chloro-4-Fluorobenzyl Cyanide
- Synonyms
- 3-CHLORO-4-FLUOROBENZYL CYANIDE;3-Chloro-4-fluorophenylacetonitrile;3-Chloro-4-fluoro benzeneacetonitrile;Benzeneacetonitrile,3-chloro-4-fluoro-;2-(3-chloro-4-fluorophenyl)acetonitrile;3-Chloro-4-fluorobenzyl cyanide, 2-(3-Chloro-4-fluorophenyl)ethanonitrile
- CBNumber
- CB82129963
- Molecular Formula
- C8H5ClFN
- Formula Weight
- 169.58
- MOL File
- 658-98-0.mol
3-Chloro-4-Fluorobenzyl Cyanide Property
- Boiling point:
- 130-134 °C(Press: 7 Torr)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
Safety
- RIDADR
- UN2810
- HazardClass
- TOXIC
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C584738
- Product name
- 3-Chloro-4-fluorophenylacetonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 002519
- Product name
- 3-Chloro-4-fluorophenylacetonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- 005670
- Product name
- 3-Chloro-4-fluorophenylacetonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- J98067
- Product name
- 3-Chloro-4-fluorobenzylcyanide
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 002519
- Product name
- 3-Chloro-4-fluorophenylacetonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $36
- Updated
- 2021/12/16
3-Chloro-4-Fluorobenzyl Cyanide Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Synthesis
773837-37-9
192702-01-5
658-98-0
Example 3: General procedure for the synthesis of 3-chloro-4-fluorophenylacetonitrile (Product 3A) from compound (CAS:773837-37-9) and 3-chloro-4-fluorobenzyl bromide. 1. In a three-necked flask equipped with a magnetic stirrer, condenser and dosing funnel, water (75 mL) was added. 2. sodium cyanide (13.16 g, 268.49 mmol) was added to the flask followed by chloroform (100 mL) and the phase transfer catalyst N-benzyl-N,N-diethylethanaminium chloride (3.06 g, 13.42 mmol). 3. The mixture was vigorously stirred at 25 °C while a chloroform solution of 3-chloro-4-fluorobenzyl bromide (30 g, 134.25 mmol) was added dropwise over 30 min. 4. After the dropwise addition, the reaction mixture was continued to be stirred at 25 °C for 3 hours and then heated to 45 °C and kept there for 2 hours. 5. After completion of the reaction, it was cooled to room temperature and the organic and aqueous layers were separated. 6. The organic layer was washed sequentially with 0.5 N NaOH solution and brine, then dried with anhydrous Na2SO4, filtered and concentrated. 7. The aqueous layers are combined, treated with 1 N NaOH solution and bleach (note the exothermic reaction), and treated according to standards for the treatment of cyanide-containing waste. 8. The final pure 3-chloro-4-fluorophenylacetonitrile (Product 3A, 22.05 g, 97% yield) was obtained as an oil. 1H NMR (500 MHz, chloroform-d) data for product 3A: δ 7.39 (dd, J = 6.56, 2.29 Hz, 1H), 7.21 (dd, J = 4.43, 2.29 Hz, 1H), 7.17 (d, J = 8.55 Hz, 1H), 3.71 (s, 2H).
References
[1] Patent: WO2010/71575, 2010, A1. Location in patent: Page/Page column 52
3-Chloro-4-Fluorobenzyl Cyanide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-4-Fluorobenzyl Cyanide Suppliers
- Tel
- --
- Fax
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- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
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View Lastest Price from 3-Chloro-4-Fluorobenzyl Cyanide manufacturers
- Product
- 3-Chloro-4-fluorophenylacetonitrile 658-98-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 3-Chloro-4-Fluorobenzyl Cyanide 658-98-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09