11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Property

solubility 

10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Chemical Properties,Usage,Production

Description

11β-13,14-dihydro-15-keto PGF_2α is a metabolite of PGD₂ in the 15-hydroxy PGDH pathway.^1,2 Infusion or inhalation of tritiated PGD₂ in normal males results in the appearance of peak levels of both 11β-PGF_2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF_2α in the plasma within 10 minutes.¹ Homogenates of human lung metabolize PGD₂ first to 11β-PGF_2α and then to 11β-15-keto-PGF_2α in the presence of NAD⁺, but not 11β-13,14-dihydro-15-keto PGF_2α.² Guinea pig liver and kidney homogenates metabolize PGD₂ to 11β-13,14-dihydro-15-keto PGF_2α, via 11β-PGF_2α, in the presence of NAD⁺ and NADP⁺.²

Definition

ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.

References

1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D₂ after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D₂. Evidence for the sequential conversion by NADPH and NAD⁺ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).