3β-Hydroxyurs-12,19-dien-28-oic acid
- Product Name
- 3β-Hydroxyurs-12,19-dien-28-oic acid
- CAS No.
- 6812-98-2
- Chemical Name
- 3β-Hydroxyurs-12,19-dien-28-oic acid
- Synonyms
- Ursa-12;Sanguisorbigenin;3β-Hydroxyurs-12;Tomentosolic acid;19-dien-28-oic acid;19-Dehydroursolic acid;Ursa-12,19-dien-28-oic acid;3β-Hydroxyurs-12,19-dien-28-oic acid;3β-Hydroxyurs-12,19-dien-28-oic acid;Ursa-12,19-dien-28-oic acid, 3-hydroxy-, (3β)-
- CBNumber
- CB82143356
- Molecular Formula
- C30H46O3
- Formula Weight
- 454.7
- MOL File
- 6812-98-2.mol
3β-Hydroxyurs-12,19-dien-28-oic acid Property
- Melting point:
- 267-268 °C (decomp)
- Boiling point:
- 563.4±50.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- pka
- 4.49±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN91139
- Product name
- Sanguisorbigenin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $413
- Updated
- 2021/12/16
3β-Hydroxyurs-12,19-dien-28-oic acid Chemical Properties,Usage,Production
Biological Activity
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1]. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1].
References
[1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244.
3β-Hydroxyurs-12,19-dien-28-oic acid Preparation Products And Raw materials
Raw materials
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