(2S,3R,E)-2-Amino-4-icosene-1,3-diol

Product Name: (2S,3R,E)-2-Amino-4-icosene-1,3-diol
CAS No.: 6918-49-6
Chemical Name: (2S,3R,E)-2-Amino-4-icosene-1,3-diol
Synonyms: C20-Sphingosine;Eicosaphingenine;Eicosasphingenine;Gangliosphingosine;Sphingosine (d20:1);20-Carbon-sphingosine;D-erythro-Sphingosine C-20;(2S,3R,4E)-4-Icosasphingenine;D-erythro-Sphingosine (d20:1);D-erythro-sphingosine (C20 base)
CBNumber: CB82148391
Molecular Formula: C20H41NO2
Formula Weight: 327.55
MOL File: 6918-49-6.mol

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(2S,3R,E)-2-Amino-4-icosene-1,3-diol Property

storage temp.: -20°C
solubility: DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: Miscible
form: A crystalline solid
BRN: 3547228

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 07768
Product name: (2S,3R,4E)-2-Amino-4-eicosene-1,3-diol
Purity: ≥98.0% (TLC)
Packaging: 10mg
Price: $203
Updated: 2023/06/20

Sigma-Aldrich

Product number: 07768
Product name: (2S,3R,4E)-2-Amino-4-eicosene-1,3-diol
Purity: ≥98.0% (TLC)
Packaging: 50mg
Price: $867
Updated: 2023/01/07

Cayman Chemical

Product number: 10007903
Product name: Sphingosine (d20:1)
Purity: ≥98%
Packaging: 500μg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 10007903
Product name: Sphingosine (d20:1)
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 10007903
Product name: Sphingosine (d20:1)
Purity: ≥98%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

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(2S,3R,E)-2-Amino-4-icosene-1,3-diol Chemical Properties,Usage,Production

Description

Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mammalian brain gangliosides apparently increases with developmental maturation. Furthermore, the ratio of C-18 to C-20 sphingosine in the brain is thought to be related to some nervous system degeneration processes.

Uses

Sphingosine (d20:1) has been used as a reference substance in liquid chromatography/tandem mass spectrometry analysis to quantitatively analyze sphingolipids with C20- long chain bases in human central nervous tissue.

Uses

D-erythro-Sphingosine-C20 is an antagonist in cell-signaling functions however it displays an opposite modulation of cathepsin D.

Definition

ChEBI: C20 sphingosine is a sphingoid that is the C20 analogue of sphingosine. It has a role as a mouse metabolite. It is a sphingoid and an aminodiol. It is a conjugate base of a C20 sphingosine(1+).

General Description

Sphingosine (d20:1), also known as icosasphingosine, is a synthetic sphingosine with 20 carbon long chain bases (LCB). It is directly produced by the sphingolipid de novo synthesis pathway and not by hydrolysis of complex sphingolipids. In higher animals, it is one of the most abundant sphingoid bases of gangliosides.

Biochem/physiol Actions

Sphingosine (d20:1) or C20-sphingosine acts as an intermediate in the synthesis of ceramides, which are vital components of mammalian epidermis. It may be involved in regulation of epidermal differentiation. C20 long chain bases-containing sphingolipids might exhibit detrimental effect on protein homeostasis and neural functions.

(2S,3R,E)-2-Amino-4-icosene-1,3-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,3R,E)-2-Amino-4-icosene-1,3-diol Suppliers

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6918-49-6, (2S,3R,E)-2-Amino-4-icosene-1,3-diolRelated Search:

(2S,3R,E)-2-Amino-4-tetradecene-1,3-diol sphingosine kinase sphingosine β-galactosyltransferase sphingosine N-acyltransferase sphingosine cholinephosphotransferase D,L-ERYTHRO-C20-DIHYDROSPHINGOSINE (2S,3R,E)-2-Amino-4-icosene-1,3-diol N-ACETYL-SPHINGOSYLPHOSPHORYLETHANOLAMINE

(2S,3R,E)-2-Amino-4-icosene-1,3-diol

D-erythro-sphingosine (C20 base)</DIV>

C20-Sphingosine

Eicosasphingenine

Gangliosphingosine

D-erythro-Sphingosine C-20

D-erythro-sphingosine (C20 base)

(2S,3R,4E)-2-Amino-4-eicosene-1,3-diol

(2S,3R,4E)-4-Icosasphingenine

20-Carbon-sphingosine

D-erythro-Sphingosine (d20:1)

Eicosaphingenine

trans-D-erythro-2-Amino-4-eicosene-1,3-diol

<DIV>D-<I>erythro</I>-sphingosine (C20 base)</DIV>

<DIV>D-<I>ERYTHRO</I>-SPHINGOSINE (C20 BASE)</DIV>;SPHINGOSINE (D20:1)

Sphingosine (d20:1)

4-Eicosene-1,3-diol, 2-amino-, (2S,3R,4E)-

Sphingosine (d20:1)/D-erythro-C20-Sphingosine

6918-49-6