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(R)-BEL

Product Name
(R)-BEL
CAS No.
478288-90-3
Chemical Name
(R)-BEL
Synonyms
(R)-BEL;(R)-BROMOENOL LACTONE;(R)-Bromoenol lactone(solution in acetate);(R) Bromoenol lactone,(R)Bromoenol lactone;(3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one;6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
CBNumber
CB8215769
Molecular Formula
C16H13BrO2
Formula Weight
317.18
MOL File
478288-90-3.mol
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(R)-BEL Property

Boiling point:
467.0±45.0 °C(Predicted)
Density 
1.538±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
10mg
Price
$365
Updated
2024/03/01
AK Scientific
Product number
1089AH
Product name
(R)-BEL
Packaging
5mg
Price
$353
Updated
2021/12/16
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(R)-BEL Chemical Properties,Usage,Production

Description

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.

Uses

(R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM[1][2].

References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2 Annu. Rev. Pharmacol. Toxicol. 39,175-189(1999).
2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells J. Biol. Chem. 277(36),32807-32814(2002).

(R)-BEL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-BEL Suppliers

China 15 United States 3 Global 18
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58

478288-90-3, (R)-BELRelated Search:

Ethyl 1-naphthaleneacetate VINYL PHENYL ACETATE (R)-BEL Methyl naphthalene-1-acetate BROMOENOL LACTONE

  • (R)-BEL
  • (R)-BROMOENOL LACTONE
  • 6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
  • (3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
  • (R) Bromoenol lactone,(R)Bromoenol lactone
  • 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
  • (R)-Bromoenol lactone(solution in acetate)
  • 478288-90-3