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(R)-BEL

Product Name
(R)-BEL
CAS No.
478288-90-3
Chemical Name
(R)-BEL
Synonyms
(R)-BEL;(R)-BROMOENOL LACTONE;(R) Bromoenol lactone,(R)Bromoenol lactone;(3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one;6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
CBNumber
CB8215769
Molecular Formula
C16H13BrO2
Formula Weight
317.18
MOL File
478288-90-3.mol
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(R)-BEL Property

Boiling point:
467.0±45.0 °C(Predicted)
Density 
1.538±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
10mg
Price
$365
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
HCH0105431
Product name
6E-(BROMOETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$503.38
Updated
2021/12/16
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(R)-BEL Chemical Properties,Usage,Production

Description

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.

References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2 Annu. Rev. Pharmacol. Toxicol. 39,175-189(1999).
2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells J. Biol. Chem. 277(36),32807-32814(2002).

(R)-BEL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-BEL Suppliers

China 7 United States 3 Global 10
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9272
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

478288-90-3, (R)-BELRelated Search:

Ethyl 1-naphthaleneacetate VINYL PHENYL ACETATE (R)-BEL Methyl naphthalene-1-acetate BROMOENOL LACTONE

  • (R)-BEL
  • (R)-BROMOENOL LACTONE
  • 6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
  • (3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
  • (R) Bromoenol lactone,(R)Bromoenol lactone
  • 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
  • 478288-90-3