1-Fluoronaphthalene

Product Name: 1-Fluoronaphthalene
CAS No.: 321-38-0
Chemical Name: 1-Fluoronaphthalene
Synonyms: Fluoronaphthalene;1-FLUORONAPTHALENE;1-Fluornaftalen;48720-u;NSC 4690;uoronaphthaL;Duloxetine-8;1-Fluoronaphth;Fluorophthalene;Duloxetine Imp-G
CBNumber: CB8219439
Molecular Formula: C10H7F
Formula Weight: 146.16
MOL File: 321-38-0.mol

More

Less

1-Fluoronaphthalene Property

Melting point:: -13 °C (lit.)
Boiling point:: 215 °C (lit.)
Density: 1.1322 g/mL at 20 °C (lit.)
refractive index: n20/D 1.593(lit.)
Flash point:: 150 °F
storage temp.: Sealed in dry,Room Temperature
solubility: slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
form: Oil
color: Colourless to Yellow
Specific Gravity: 1.332
Water Solubility: Not miscible or difficult to mix in water.
BRN: 1906413
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS DataBase Reference: 321-38-0(CAS DataBase Reference)
NIST Chemistry Reference: Naphthalene, 1-fluoro-(321-38-0)
EPA Substance Registry System: 1-Fluoronaphthalene (321-38-0)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN2810
WGK Germany: 3
RTECS: QJ7100000
Hazard Note: Flammable
TSCA: T
HazardClass: IRRITANT
HS Code: 29039990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 196657
Product name: 1-Fluoronaphthalene
Purity: 99%
Packaging: 5g
Price: $40.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 196657
Product name: 1-Fluoronaphthalene
Purity: 99%
Packaging: 25g
Price: $120
Updated: 2024/03/01

TCI Chemical

Product number: F0212
Product name: 1-Fluoronaphthalene
Purity: >98.0%(GC)
Packaging: 5g
Price: $19
Updated: 2024/03/01

TCI Chemical

Product number: F0212
Product name: 1-Fluoronaphthalene
Purity: >98.0%(GC)
Packaging: 25g
Price: $45
Updated: 2024/03/01

Alfa Aesar

Product number: A18378
Product name: 1-Fluoronaphthalene, 98%
Packaging: 5g
Price: $31.65
Updated: 2024/03/01

More

Less

1-Fluoronaphthalene Chemical Properties,Usage,Production

Chemical Properties

clear slightly yellow to yellow-brown liquid

Uses

1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.

Application

1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.

Preparation

The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1-Fluoronaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

4-Fluoronaphtalene-1-boronic acid 2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE Duloxetine

More

Less

1-Fluoronaphthalene Suppliers

Americas 1 Belgium 3 Canada 1 China 508 Europe 6 France 3 Germany 9 India 61 Italy 1 Japan 6 Norway 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 21 United States 61 Global 687

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Fisher Scientific Uk Ltd.

Tel: --
Fax: --
Email: .international@thermofisher.com
Country: United Kingdom
ProdList: 2932
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Melrob Ltd (part of Nordmann)

Tel: --
Fax: --
Email: nquiries@melrob.com
Country: United Kingdom
ProdList: 3065
Advantage: 58

JRD Fluorochemicals Ltd

Tel: --
Fax: --
Email: sales@jrdfluoro.co.uk
Country: United Kingdom
ProdList: 2774
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Molekula Ltd

Tel: --
Fax: --
Email: info@molekula.com
Country: United Kingdom
ProdList: 4060
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

JRD Fluorochemicals Ltd.

Tel: --
Fax: --
Email: sales@jrdfluoro.co.uk
Country: United Kingdom
ProdList: 1729
Advantage: 38

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

More

Less

View Lastest Price from 1-Fluoronaphthalene manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 1-Fluoronaphthalene 321-38-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

airuikechemical co., ltd.

Product: 1-fluoronaphthalene 321-38-0
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

Hebei Chuanghai Biotechnology Co,.LTD

Product: Fluoronaphthalene 321-38-0
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-21

321-38-0, 1-FluoronaphthaleneRelated Search:

1-Bromo-4-fluoronaphthalene 98%,1-Bromo-4-fluoronaphthalene,98%,1-BROMO-4-FLUORONAPHTHALENE 4-FLUORONAPHTHALENE-1-SULFONYL CHLORIDE,4-FLUORONAPHTHALENE-1-SULPHONYL CHLORIDE 1-ACETYL-4-FLUORONAPHTHALENE, 97% 4-FLUORONAPHTHALENE-1-BORONIC ACID,4-Fluoronaphthalene-1-boronic acid ,98% 4-FLUORO-1-NAPHTHOIC ACID Octafluoronaphthalene 1-Fluoronaphthalene 1-Fluoro-4-nitronaphthalene 2-AMINOHEPTAFLUORONAPHTALENE 1-CYANO-4-FLUORONAPHTHALENE,4-Fluoronaphthalene-1-carbonitrile, 97% 1-Amino-4-fluoronaphthalene 1-AMINO-8-FLUORONAPHTHALENE 2-FLUORENECARBOXALDEHYDE Perfluorodecalin beta-Fluoronaphthalene,2-FLUORONAPHTHALENE,2-Fluoronaphthalene solution,2-FLUORONAPHTHALENE, 100MG, NEAT 4-BROMO-1-FLUORONAPHTHALENE-2-BORONIC ACID,4-Bromo-1-fluoronaphthalene-2-boronic acid 98%,4-Bromo-1-fluoronaphthalene-2-boronicacid98% 3-BROMO-1-FLUORONAPHTHALENE,98+%(GC),3-BROMO-1-FLUORONAPHTHALENE 6-fluoronaphthalene-1-carboxylic acid

1-Fluornaftalen

1-fluoro-naphthalen

NSC 4690

α-fluorinated naphthalene

Duloxetine USP IMpurity G

naphthyl fluoride C10H7F, α

Duloxetine EP IMpurity G

1 - fluorinated naphthalene

Naphthalene,1-fluoro-

1-Fluoronaphthalene, 97+%

1-Fluoronaphth

Duloxetine Hydrochloride impurity G

1-FLUORONAFTALENO

Fluorophthalene

1-fluoromaphthalene

1-Fluoronaphthalene 99.5%

low price 1-Fluoronaphthalene 321-38-0

Duloxetine Impurity 13

alpha-Fluoronaphthalene

1-FLUORONAPHTHALENE

1-FLUORONAPTHALENE

Fluoronaphthalene

1-FLUORONAPHTHALENE, 1000MG, NEAT

I-Fluoronaphthalene

1-Fluoronaphthalene99%

I-Fluornaphthalin

1-Fluoronaphthalene,98%

1-Fluoronaphthalene solution

48720-u

uoronaphthaL

Duloxetine EP Impurity G (USP RC G)

1-FLUORONAPHTHALENE NEAT

low price 1-Fluoronaphthalene

Duloxetine impurity G

Duloxetine-8

1-fluoronaphthlene

1-Fluoronaphthalene@2.0 mg/mL in Dichloromethane

1-Fluoronaphthalene@0.2 mg/mL in CH2Cl2

1-Fluoronaphthalene @0.1 mg/mL in Acetone

2-Fluorobiphenyl &amp

1-Fluoronaphthalene@2.0 mg/mL in CH2Cl2

1-FluoronaphthaleneSolution,1,000mg/L,1mL

1-Fluornaphthalin

Duloxetine EP Impurity G (α-fluonaphthalene)

1 - fluorinated naphthalene Finn

1-fluoronaphthalene(For export only)

1-Fluoronaphthalene ISO 9001：2015 REACH

α-Fluoronaphthalene

1-Fluoronaphthalene (Duloxetine Impurity)

Duloxetine Imp-G

Duloxetine Impurity58

Duloxetine Impurity 13(Duloxetine EP Impurity G)

Duloxetine Hydrochloride EP Impurity G

1-Fluorinaphthalene

Dapoxetine hydrochloride Impurity C

1-Fluornaphthalene

1-Fluoronaphthalene in isooctane

321-38-0