ChemicalBook > CAS DataBase List > 1-Fluoronaphthalene

1-Fluoronaphthalene

Product Name
1-Fluoronaphthalene
CAS No.
321-38-0
Chemical Name
1-Fluoronaphthalene
Synonyms
Fluoronaphthalene;1-FLUORONAPTHALENE;1-Fluornaftalen;48720-u;NSC 4690;uoronaphthaL;Duloxetine-8;1-Fluoronaphth;Fluorophthalene;Duloxetine Imp-G
CBNumber
CB8219439
Molecular Formula
C10H7F
Formula Weight
146.16
MOL File
321-38-0.mol
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1-Fluoronaphthalene Property

Melting point:
-13 °C (lit.)
Boiling point:
215 °C (lit.)
Density 
1.1322 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.593(lit.)
Flash point:
150 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
form 
Oil
color 
Colourless to Yellow
Specific Gravity
1.332
Water Solubility 
Not miscible or difficult to mix in water.
BRN 
1906413
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS DataBase Reference
321-38-0(CAS DataBase Reference)
NIST Chemistry Reference
Naphthalene, 1-fluoro-(321-38-0)
EPA Substance Registry System
1-Fluoronaphthalene (321-38-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN2810
WGK Germany 
3
RTECS 
QJ7100000
Hazard Note 
Flammable
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196657
Product name
1-Fluoronaphthalene
Purity
99%
Packaging
5g
Price
$38.88
Updated
2025/07/31
Sigma-Aldrich
Product number
196657
Product name
1-Fluoronaphthalene
Purity
99%
Packaging
25g
Price
$86.8
Updated
2025/07/31
TCI Chemical
Product number
F0212
Product name
1-Fluoronaphthalene
Purity
>98.0%(GC)
Packaging
5g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
F0212
Product name
1-Fluoronaphthalene
Purity
>98.0%(GC)
Packaging
25g
Price
$45
Updated
2025/07/31
TRC
Product number
F593760
Product name
1-Fluoronaphthalene
Packaging
1g
Price
$55
Updated
2021/12/16
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1-Fluoronaphthalene Chemical Properties,Usage,Production

Chemical Properties

clear slightly yellow to yellow-brown liquid

Uses

1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.

Application

1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.

Preparation

The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1-Fluoronaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

4-Fluoronaphtalene-1-boronic acid 2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE Duloxetine
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1-Fluoronaphthalene Suppliers

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View Lastest Price from 1-Fluoronaphthalene manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-Fluoronaphthalene 321-38-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-08-21
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Fluoronaphthalene 321-38-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-10
Chongqing Soarwin Technology Co., Ltd
Product
1-Fluoronaphthalene 321-38-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-16

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