ChemicalBook > CAS DataBase List > 2,4-Dimethoxybenzeneboronic acid

2,4-Dimethoxybenzeneboronic acid

Uses Uses

Product Name: 2,4-Dimethoxybenzeneboronic acid
CAS No.: 133730-34-4
Chemical Name: 2,4-Dimethoxybenzeneboronic acid
Synonyms: AKOS BRN-0063;RARECHEM AH PB 0099;2,4-Dimethoxybenzene;DiMethoxyphenylboronic aci;4-DiMethoxybenzeneboronic acid;2,4-Dimethoxyphenylbornic acid;2,4-Dimethoxybenzeneboronicaci;2,4-DIMETHOXYPHENYLBORONIC ACID;2,2-Dimethoxyphenylboronic Acid;2,4-DIMETHOXYBENZENEBORONIC ACID
CBNumber: CB8222554
Molecular Formula: C8H11BO4
Formula Weight: 181.98
MOL File: 133730-34-4.mol

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2,4-Dimethoxybenzeneboronic acid Property

Melting point:: 125-127 °C (lit.)
Boiling point:: 361.1±52.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 8.98±0.58(Predicted)
color: White to Dark green
BRN: 4744213
InChI: InChI=1S/C8H11BO4/c1-12-6-3-4-7(9(10)11)8(5-6)13-2/h3-5,10-11H,1-2H3
InChIKey: SQTUYFKNCCBFRR-UHFFFAOYSA-N
SMILES: B(C1=CC=C(OC)C=C1OC)(O)O
CAS DataBase Reference: 133730-34-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36/37-24/25
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29420000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 483486
Product name: 2,4-Dimethoxyphenylboronic acid
Purity: 95%
Packaging: 1g
Price: $26.74
Updated: 2025/07/31

Sigma-Aldrich

Product number: 483486
Product name: 2,4-Dimethoxyphenylboronic acid
Purity: 95%
Packaging: 10g
Price: $365
Updated: 2025/07/31

TCI Chemical

Product number: D3521
Product name: 2,4-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: D3521
Product name: 2,4-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TRC

Product number: D479205
Product name: 2,4-Dimethoxyphenylboronic acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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2,4-Dimethoxybenzeneboronic acid Chemical Properties,Usage,Production

Uses

2,4-Dimethoxyphenylboronic acid can be used:

• As a reactant in meatal-catalyzed Suzuki−Miyaura cross-coupling reaction.

• To prepare hydroxy(trimethoxy)phenanthrene by cross-coupling with bromo(benzyloxy)methoxybenzaldehyde followed by condensation and debenzylation reaction.

• To synthesize 2,4-dimethoxy-1-(trifluoromethyl)benzene via Cu-catalyzed trifluoromethylation reaction.

Uses

Reactant for:

• Suzuki-Miyaura and Negishi couplings.

Chemical Properties

white to beige or pink moist powder

Uses

suzuki reaction

Uses

2,4-Dimethoxyphenylboronic acid can be used:

As a reactant in meatal-catalyzed Suzuki?Miyaura cross-coupling reaction.
To prepare hydroxy(trimethoxy)phenanthrene by cross-coupling with bromo(benzyloxy)methoxybenzaldehyde followed by condensation and debenzylation reaction.
To synthesize 2,4-dimethoxy-1-(trifluoromethyl)benzene via Cu-catalyzed trifluoromethylation reaction.

Synthesis

17715-69-4

133730-34-4

The general procedure for the synthesis of 2,4-dimethoxyphenylboronic acid from 2,4-dimethoxybromobenzene was as follows: first, 576 μL of 1-bromo-2,4-dimethoxybenzene was dissolved in 5.8 mL of tetrahydrofuran, which was cooled to -78 °C under argon protection. Subsequently, 3 mL of 1.6 mol/L n-butyllithium hexane solution was slowly added dropwise. After the dropwise addition, 1.1 mL of triisopropyl borate was added and the reaction continued to be stirred at -78 °C for 40 minutes, after which it was brought to room temperature and stirred for 2 hours. Upon completion of the reaction, the reaction mixture was quenched by adding 40 mL of water and 1 mL of 5N hydrochloric acid to the reaction mixture and then extracted with 50 mL of ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. Finally, 610.2 mg of 2,4-dimethoxyphenylboronic acid was purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate=2:1). The product was characterized by 1H-NMR (CDCl3): δ (ppm) 3.85 (3H, s), 3.89 (3H, s), 5.81 (2H, s), 6.46 (1H, s), 6.56 (1H, dd, J = 2.0,8.4 Hz), 7.77 (1H, d, J = 8.4 Hz).

References

[1] Organic Letters, 2000, vol. 2, # 5, p. 629 - 631
[2] Journal of the American Chemical Society, 2006, vol. 128, # 22, p. 7176 - 7178
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 4710 - 4719
[5] Patent: US2014/30209, 2014, A1. Location in patent: Paragraph 0295; 0296

2,4-Dimethoxybenzeneboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dimethoxybenzeneboronic acid Suppliers

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View Lastest Price from 2,4-Dimethoxybenzeneboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,4-Dimethoxybenzeneboronic acid 133730-34-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2025-03-14

Henan Fengda Chemical Co., Ltd

Product: 2,4-Dimethoxybenzeneboronic acid 133730-34-4
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4-Dimethoxybenzeneboronic acid 133730-34-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

133730-34-4, 2,4-Dimethoxybenzeneboronic acidRelated Search:

Dimethyldimethoxysilane 3,5-Dimethylphenylboronic acid 4-Methoxyphenylboronic acid Phenylboronic acid (4-METHOXYPHENYL)-BORANE Dibutyl phthalate 1,1-Dimethoxyethane Dimethoxymethane 2,4,6-TRIMETHOXYBENZENEBORONIC ACID ETHYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3-tert-Butoxycarbonylphenylboronic acid 3-METHOXYCARBONYL-5-NITROPHENYLBORONIC ACID 3-AMINO-5-METHOXYCARBONYLPHENYLBORONIC ACID, HCL 2,4-DIBUTOXYPHENYLBORONIC ACID 3-Cyanophenylboronic acid 3-BENZYLOXYCARBONYLPHENYLBORONIC ACID 2-METHOXY-4-(TRIFLUOROMETHOXY)-PHENYLBORONIC ACID 2,4-DIMETHOXYPHENYLBORONIC ACID, PINACOL ESTER

RARECHEM AH PB 0099

2,4-DIMETHOXYPHENYLBORONIC ACID

2,4-DIMETHOXYBENZENEBORONIC ACID

AKOS BRN-0063

2,4-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)

2,4-Dimethoxyphenylboronic acid ,98%

2,4-Dimethoxybenzeneboronic acid,97%

2,4-DIMETHOXYBENZENEBORONIC ACID,98+%

DiMethoxyphenylboronic aci

2,2-Dimethoxyphenylboronic Acid

2,4-Dimethoxybenzene

2,4-Dimethoxyphenylboronic acid , May contain varying amounts of anhydride, 97%

4-DiMethoxybenzeneboronic acid

2,4-Dimethoxyphenylboronic acid 95%

2,4-DiMeth 2,4-DiMethoxybenzeneboronic acidoxybenzeneboronic acid

2,4-Dimethoxyphenylbornic acid

Boronic acid, B-(2,4-dimethoxyphenyl)-

2,4-Dimethoxybenzeneboronicaci

2,4-Dimethoxyphenylboronic acid - [D2720]

133730-34-4

133730-43-4

BORONIC ACID

Aryl

Boronic Acids and Derivatives

Boronic Acids

Organometallic Reagents

Aryl Boronic Acids

Boronic Acids and Derivatives

Chemical Synthesis

Disubstituted Aryl Boronic Acids

Organometallic Reagents

Boronic acids

Boronic Acid

Substituted Boronic Acids

blocks

BoronicAcids

Alkoxy

Aryl

Organoborons

B (Classes of Boron Compounds)

Boronic Acids

Boronic Acids and Derivatives