Amentoflavone 4',4''',7''-trimethyl ether
- Product Name
- Amentoflavone 4',4''',7''-trimethyl ether
- CAS No.
- 481-45-8
- Chemical Name
- Amentoflavone 4',4''',7''-trimethyl ether
- Synonyms
- Kayaflavone;Amentoflavone 4',4''',7''-trimethyl ether;Amentoflavone 4',4''',7''-trimethyl ether USP/EP/BP;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;2-(4-Methoxyphenyl)-5-hydroxy-7-methoxy-8-[2-methoxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-
- CBNumber
- CB82256692
- Molecular Formula
- C33H24O10
- Formula Weight
- 580.54
- MOL File
- 481-45-8.mol
Amentoflavone 4',4''',7''-trimethyl ether Property
- Melting point:
- 314-315 °C (decomp)(Solv: methanol (67-56-1))
- Boiling point:
- 815.4±65.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- pka
- 6.00±0.40(Predicted)
Amentoflavone 4',4''',7''-trimethyl ether Chemical Properties,Usage,Production
Uses
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC50 value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease[1].
Synthesis
Willow leaf loosestrife leaves crushed, weighing 20kg, with 8 times 90% methanol solution ultrasonic extraction for 30 minutes, extracted three times, the extract was concentrated under reduced pressure and added to the HZ816 macroporous resin column adsorption, with 5 times the volume of the column 50% methanol solution elution, and then 8 times the volume of the column 85% methanol solution elution, the eluent was concentrated and adjusted to ph4, add ethyl acetate stirred thoroughly, collect the ethyl acetate layer, the solid was obtained. Crude extract. Take chloroform, methanol, water, according to 3:2:1 mixing, fully layered, take the upper phase filled with high-speed counter-current chromatography tube as stationary phase, turn on the host, speed 800rpm, while pumping the lower phase to do the fluid phase, the establishment of dynamic equilibrium, the flow rate is adjusted to 2ml/min, with the mobile phase to dissolve the extracts, by the injection valve into the sample, the evaporation of light scattering detector on-line monitoring, the collection of target components, continuous preparation, flow points The reagent was recovered to obtain 1.2 g of Cephalosporin, which was detected as 99.5% by HPLC.
References
[1] Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. DOI:10.1016/j.bmcl.2015.04.106
[2] Sun CM, et al. Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod. 1997 Apr;60(4):382-4. DOI:10.1021/np960608e
Amentoflavone 4',4''',7''-trimethyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
Amentoflavone 4',4''',7''-trimethyl ether Suppliers
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7777
- Advantage
- 56
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 028-85370565-229 18080489829
- 18080489829@163.com
- Country
- China
- ProdList
- 7974
- Advantage
- 60
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 18895
- Advantage
- 58
- Tel
- 0871-65217109
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 2794
- Advantage
- 58
- Tel
- 18301908279 18301908279;
- Fax
- 021-54387656
- 1292752157@qq.com
- Country
- China
- ProdList
- 7683
- Advantage
- 58
- Tel
- 021-57763112 13585886131
- 3004987436@qq.com
- Country
- China
- ProdList
- 9692
- Advantage
- 58
- Tel
- 400-8087372 13161114455
- puxi_sale@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58
- Tel
- 021-38218169 13681877033
- 2702713455@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58