AMENTOFLAVONE

Product Name: AMENTOFLAVONE
CAS No.: 602-06-2
Chemical Name: AMENTOFLAVONE
Synonyms: skyrin;Skirin;Endothianin;Rhodophyscin;3',8''-BIAPIGENIN;I3,II8 BIAPIGENIN;DIDEMETHYL-GINKGETIN;4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE;(+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthraquinone;2,4,5,2',4',5'-hexahydroxy-7,7'-dimethyl-[1,1']bianthryl-9,10,9',10'-tetraone
CBNumber: CB6744025
Molecular Formula: C30H18O10
Formula Weight: 538.46
MOL File: 602-06-2.mol

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AMENTOFLAVONE Property

Melting point:: >380℃
Boiling point:: 956.1±65.0 °C(Predicted)
Density: 1.698±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble
pka: 5.24±0.20(Predicted)
form: A crystalline solid
color: Orange to dark red
biological source: Penicillium islandicum

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0459
Product name: Skyrin
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $290
Updated: 2024/03/01

Cayman Chemical

Product number: 13102
Product name: Skyrin
Purity: ≥97%
Packaging: 1mg
Price: $183
Updated: 2024/03/01

Usbiological

Product number: 045303
Product name: Skyrin
Packaging: 1mg
Price: $375
Updated: 2021/12/16

TRC

Product number: S555053
Product name: Skyrin
Packaging: 1mg
Price: $165
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0001-M001
Product name: Skyrin
Purity: ≥97%(HPLC)
Packaging: 1mg
Price: $150
Updated: 2021/12/16

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AMENTOFLAVONE Chemical Properties,Usage,Production

Uses

Skyrin is a non-peptidic anthraquinone, mycotoxin.

Definition

ChEBI: Skyrin is a biaryl and a trihydroxyanthraquinone. It is functionally related to an emodin.

Biological Activity

Skyrin is a non-peptidic anthraquinone, mycotoxin with in vitro cytotoxic activity. It suppresses the growth of HeLa, Vero, K562, Raji, Wish and Calu-1 cell lines. Skyrin treatment induces DNA fragmentation and other morphological changes leading to apoptosis in Human HL-60 promyelotic leukemia cells. Skyrin was found to serve as an anti-diabetic agent by selectively binding to the glucagon receptor acting as its antagonist. Regular binding of glucagon to its receptor on hepathocyte plasma membrane activates adenylate cyclase indirectly. As a result, the cAMP produced activates protein kinase A with a consequent increase in both glycogen breakdown and gluconeogenesis leading to glucose output. Skyrin was shown to block this signal transduction sequence, such th at the interaction of glucagons with its receptor does not result in an increase in cAMP production. Skyrin was also found to efficiently scavenge free radical species as ?OH, ?R and of singlet oxygen (1O2). Based on Skyrin selective toxicity towards insect cell line Sf9, it may be useful as an agent for pest control.

storage

+4°C

AMENTOFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMENTOFLAVONE Suppliers

CHINA 48 Germany 2 Japan 1 Switzerland 1 United Kingdom 4 United States 9 Global 65

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
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ProdList: 3989
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Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
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Novachemistry

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Hubei Jusheng Technology Co.,Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Meng Cheng Technology (Shanghai) Co., LTD

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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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602-06-2, AMENTOFLAVONERelated Search:

Protocatechuic acid Triptolide Quercetin Carthamus Tinctorius L. P.E. Hypericin Catalpol Kaempferol GINKGETIN Sciadopitysin Amentoflavone 4',4''',7''-trimethyl ether AMENTOFLAVONE-4'''-METHYL ETHER,AMENTOFLAVONE-4''-METHYL ETHER Amentoflavone Amentoflavone 4''',7,7''-trimethyl ether Amentoflavone 1- Amino-cyclopropane-1-acid hydrochloride amentoflavone hexaacetate AMENTOFLAVONE-4'-METHYL ETHER Amentoflavone 7,4',7'',4'''-tetramethyl ether

4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE

3',8''-BIAPIGENIN

DIDEMETHYL-GINKGETIN

I3,II8 BIAPIGENIN

Endothianin

Skirin

skyrin

(+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthracene-9,9',10,10'-tetrone

(+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthraquinone

Rhodophyscin

2,4,5,2',4',5'-hexahydroxy-7,7'-dimethyl-[1,1']bianthryl-9,10,9',10'-tetraone

[1,1'-Bianthracene]-9,9',10,10'-tetrone, 2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-, (1S)-

602-06-2

Biochemicals and Reagents

BioChemical

Natural Dyes