Catalpol

Product Name: Catalpol
CAS No.: 2415-24-9
Chemical Name: Catalpol
Synonyms: CATAPOL;CATALPOL;Catalpol-RM;catalpinoside;Catapol ,>=98%;Catalpol，Catalnol;Catalpol 2415-24-9;CATALPOL WITH HPLC;,6-beta,6a-alpha))-;Catalpol, ≥97%(HPLC)
CBNumber: CB6127844
Molecular Formula: C15H22O10
Formula Weight: 362.33
MOL File: 2415-24-9.mol

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Catalpol Property

Melting point:: 203-205°C
Boiling point:: 675.6±55.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: Solid
pka: 12.79±0.70(Predicted)
color: White to Off-White
InChI: InChI=1/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/s3
InChIKey: LHDWRKICQLTVDL-CLLMHHLUSA-N
SMILES: C([C@]12O[C@H]1[C@@H](O)[C@]1([H])C=CO[C@@H](O[C@@]3([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@]21[H])O |&1:1,3,4,6,11,13,15,16,18,20,25,r|
LogP: -4.609 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: LZ5776816
HS Code: 29389090
Toxicity: mouse,LD,intravenous,> 2500mg/kg (2500mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 93, 1968.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89595
Product name: Catalpol
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $532
Updated: 2025/07/31

Sigma-Aldrich

Product number: 50839
Product name: Catalpol
Purity: ≥96% (HPLC)
Packaging: 25mg
Price: $325
Updated: 2025/07/31

TCI Chemical

Product number: C3494
Product name: Catalpol
Packaging: 250MG
Price: $276
Updated: 2025/07/31

Cayman Chemical

Product number: 24925
Product name: Catalpol
Purity: ≥98%
Packaging: 50mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 24925
Product name: Catalpol
Purity: ≥98%
Packaging: 100mg
Price: $106
Updated: 2024/03/01

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Catalpol Chemical Properties,Usage,Production

Description

Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.

Chemical Properties

Light brown powder

Uses

Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain.

Definition

ChEBI: Catalpol is an organic molecular entity. It has a role as a metabolite.

in vivo

Catalpol (25-100?mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities^[1].

Animal Model:	C57BL/6 mice treated with renal ischemia/reperfusion surgery^[1]
Dosage:	25 mg/kg, 50 mg/kg and 100?mg/kg
Administration:	Intraperitoneal injection; once
Result:	Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.

References

[1] YANJIE WANG. Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography.[J]. Journal of Analytical Methods in Chemistry, 2016, 2016: 4956589. DOI: 10.1155/2016/4956589
[2] WENNA CHEN. Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells[J]. British Journal of Pharmacology, 2013, 169 5: 1140-1152. DOI: 10.1111/bph.12200
[3] LING-AI HU. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway.[J]. Bioscience Reports, 2016, 36 3. DOI: 10.1042/bsr20160132
[4] CHENGJIE CHEN. Radio-protective effect of catalpol in cultured cells and mice.[J]. Journal of Radiation Research, 2013, 54 1: 76-82. DOI: 10.1093/jrr/rrs080
[5] HUI-FENG ZHU. Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion.[J]. International Journal of Biological Sciences, 2010, 6 5: 443-453. DOI: 10.7150/ijbs.6.443

Catalpol Preparation Products And Raw materials

Raw materials

Preparation Products

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Catalpol Suppliers

China 288 Europe 1 France 2 Germany 5 India 2 Japan 1 South Korea 1 United Kingdom 6 United States 23 Global 329

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
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Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
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Nanjing Dasf Biotechnology Co., Ltd.

Tel: 025-025-+86-02585846866 +86-18094231287
Fax: 025-83144123
Email: 1773155960@qq.com
Country: China
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Xi'an Tianlangyuan Biotechnology Co., Ltd.

Tel: 029-17749038280 17749038280
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Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
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Shandong Xiya Chemical Co., Ltd

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Fax: 0539-6365991
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Sichuan Kulinan Technology Co., Ltd

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China Langchem Inc.

Tel: 0086-21-58956006
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View Lastest Price from Catalpol manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Catalpol 2415-24-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000kgs
Release date: 2025-05-23

Shaanxi Dideu New Materials Co. Ltd

Product: Catalpol 2415-24-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-26

ANHUI WITOP BIOTECH CO., LTD

Product: Catalpol 2415-24-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-03-19

2415-24-9, CatalpolRelated Search:

Citric acid Palmatine chloride alpha-Cyperone Verbascoside Salicylic acid Ferulic Acid Artemisinin VERPROSIDE PICROSIDE I Catalpol 6'-VANILLOYL CATALPOL,Vanilloyl catalpol Dihydrocatalpol 6-O-Cinnamoyl Catalpol [(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-[(E)-3-(4-hydroxy-3-methoxyphenyl)propenoyloxy]-1aβ-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside Acetylcatalpol gmelinol Catalpol std.,CATALPOL(RG) CATALPOL(SH)

CATALPOL

CATAPOL

,6-beta,6a-alpha))-

beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)

catalpinoside

de(p-hydroxybenzoyl)catalposide

des-p-hydroxybenzoyl-catalposid

oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta,2-beta,5a-beta

Catalpol 2415-24-9

Catalpol, ≥97%(HPLC)

[1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6a.alpha.)]-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-beta-D-glucopyranoside

.beta.-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno4,5cyclopenta1,2-cpyran-2-yl

CATALPOL WITH HPLC

1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-

Catalpol，Catalnol

[(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside

Catapol ,>=98%

(1AS-(1aα,1bβ,2β,5aβ,6β,6aα-))1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxyMethyl)oxireno(4,5)cyclopenta(1,2-c)-pyran-2-yl-beta-D-glucopyranoside

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside

Digitalis purpurea L

(3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl

(2S,3R,4S,5S,6R)-2-[[(1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

(2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2S, 3R, 4S, 5S, 6R) -2- (((1aS, 1bS, 2S, 5aR, 6S, 6aS) -6-hydroxy-1a - (hydroxymethyl) -1a, 1b, 2,5a, 6,6a - hexahydroepoxyethano [2 ', 3': 4,5] cyclopentadieno [1,2-c] pyran-2-yl) oxy) -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol

Catalpol-RM

Catalpol, 10 mM in DMSO

(2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-glucopyranoside

2415-24-9

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

Iridoids