Palmatine chloride
- Product Name
- Palmatine chloride
- CAS No.
- 10605-02-4
- Chemical Name
- Palmatine chloride
- Synonyms
- PALMATINE HYDROCHLORIDE;Huangtengsu;Palmatine HCL;Palatinechloride;PALMATINE CHLORIDE;BERBERICINE CHLORIDE;Fibrauretin Chloride;Palmatine chloride-RM;PalMatin hydrochloride;Palmatine chloride, ≥98%
- CBNumber
- CB8467599
- Molecular Formula
- C21H22ClNO4
- Formula Weight
- 387.86
- MOL File
- 10605-02-4.mol
Palmatine chloride Property
- Melting point:
- 205℃
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- color
- Yellow
- InChI
- InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
- InChIKey
- RLQYRXCUPVKSAW-UHFFFAOYSA-M
- SMILES
- C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-]
Safety
- Risk Statements
- 20/22-36/38
- Safety Statements
- 24/45
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 30318
- Product name
- Palmatine (chloride)
- Packaging
- 500mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 30318
- Product name
- Palmatine (chloride)
- Packaging
- 1g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 30318
- Product name
- Palmatine (chloride)
- Packaging
- 5g
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 300750
- Product name
- Palmatine Chloride
- Packaging
- 20mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- P144200
- Product name
- PalmatineChloride
- Packaging
- 10g
- Price
- $575
- Updated
- 2021/12/16
Palmatine chloride Chemical Properties,Usage,Production
Description
Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction. The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles.
Description
Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.
Uses
Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.
Uses
antibacterial, antimalarial, uterine contractant
in vivo
Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells[1].? Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice[2].? Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice[4].? Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice[5].
| Animal Model: | DSS- induced Colitis BALB/c mice model (8-week-old)[1] |
| Dosage: | 50 or 100 mg/kg |
| Administration: | Orally, daily, for 7 days |
| Result: | Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells; remarkably extended the colon length; significantly suppressed the colonic MPO activity. Decreased the levels of colonic inflammatory cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10); Protected mucosal integrity by modulating TJs protein and apoptosis proteins; Restored DSS-induced decreases of TJ protein ZO-1, ZO-2 and claudin-1; Reduced Bax expression and enhanced Bcl-2 expression at the dose of 100?mg/kg, prevented epithelial apoptosis and improved intestinal integrity. Prevented DSS-induced changes of gut microbiota in colitis mice. |
| Animal Model: | Male ICR mice (20–22 g), D-galactosamine/lipopolysaccharide (GalN/LPS)-induced fulminant hepatic failure model[2] |
| Dosage: | 25, 50, 100, or 200 mg/kg |
| Administration: | Intraperitoneal injection, 1 h before the GalN/LPS treatment |
| Result: | Attenuated the mortality and serum aminotransferase activities increased by GalN/LPS. Prevented the increase of serum TNF-α and augmented that of serum IL-10. Decreased the TNF-a mRNA expression and increased the IL-10 mRNA expression. Attenuated the apoptosis of hepatocytes. |
| Animal Model: | Swiss young male albino mice, with Scopolamine (HY-N0296)- and diazepam-induced amnesia model[4] |
| Dosage: | 0.1, 0.5, 1 mg/kg |
| Administration: | Intraperitoneal injection, 10 days |
| Result: | Significantly improved learning and memory of mice at 0.5 and 1 mg/kg and did not show any significant effect on locomotor activity of the mice. Significantly reversed scopolamine- and diazepam-induced amnesia in mice. Significantly reduced brain acetylcholinesterase activity of mice. |
| Animal Model: | BALB/c-nude mice, HCT-116 xenograft model[5] |
| Dosage: | 33.75, 67.5 and 135 mg/kg |
| Administration: | Oral administration, once a day for 26 days |
| Result: | The tumor volume and weight of the treatment group were significantly reduced. |
target
Antifection
IC 50
IDO-1: 3 μM (IC50, HEK 293-hIDO-1); IDO-1: 157 μM (IC50, rhIDO-1); WNV NS2B-NS3: 96 μM (IC50)
References
Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975)
Palmatine chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Palmatine chloride manufacturers
- Product
- Palmatine chloride 10605-02-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 90% 98% 99%
- Supply Ability
- 1000 kg
- Release date
- 2025-03-20
- Product
- Palmatine hcl 10605-02-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- CP2020
- Supply Ability
- 10tons
- Release date
- 2023-08-04
- Product
- Palmatine hydrochloride 10605-02-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-24