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Palmatine

Product Name
Palmatine
CAS No.
3486-67-7
Chemical Name
Palmatine
Synonyms
matine;palmatin;Palatine;PALMATINE;Burasaine;Calystigine;Hindarinine;berbericinine;Cascara amarga;Palmatine USP/EP/BP
CBNumber
CB6781763
Molecular Formula
C21H22NO4+
Formula Weight
352.4
MOL File
3486-67-7.mol
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Palmatine Property

Melting point:
205°C
storage temp. 
Inert atmosphere,2-8°C
CAS DataBase Reference
3486-67-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
300751
Product name
Palmatine
Packaging
20mg
Price
$263
Updated
2021/12/16
AK Scientific
Product number
V1557
Product name
Palmatine
Packaging
1g
Price
$298
Updated
2021/12/16
ChemScene
Product number
CS-0013950
Product name
Palmatine
Packaging
20mg
Price
$140
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594172
Product name
Palmatine
Packaging
20 mg
Price
$187
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012894
Product name
PALMATINE
Purity
98.00%
Packaging
100MG
Price
$215.25
Updated
2021/12/16
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Palmatine Chemical Properties,Usage,Production

Description

This quaternary alkaloid occurs frequently in the Rhoeadales, being found in Cop tis japonica Mak. (Ranunculaceae); Berberis heteropoda Schrenk; B. vulgaris L. (Berberidaceae); Coscinium blumeatum Miers; Fibrauria chloroleuca Miers;Jatrorrhiza palmata (Lam.) Miers. (Menispermaceae); and Phellodendron amurense Rupr. (Rutcaeae). The base is usually obtained as the iodide dihydrate forming orange-yellow needles from H20, m.p. 241°C (dec.). Other salts that have been prepared include the chloride, green-yellow needles from H20, m.p. 205°C (dec.); nitrate, yellow needles, from H20, m.p. 239°C (dec.); perchlorate, m.p. 262°C (dec.); sulphate, m.p. 250°C; platinichloride, m.p. 236°C and the thiocyanate, m.p. 210°C (dec.). The alkaloid resembles berberine in yielding addition compounds with CHCl3 and Me2CO. On catalytic hydrogenation it gives tetrahydropalmatine, while on oxidation with alkaline KMn04 it furnishes corydaldine and hemipinic acid.

Physical properties

Appearance: yellow needle crystal, odorless, taste very bitter. Solubility: freely solu ble in hot water, sparingly soluble in water, slightly soluble in ethanol and chloroform, and almost insoluble in ether. Melting point: 205 °C. Relative density: 1.2 g/cm3 .

History

In the middle of the last century, Garrison health team of China and Honghe state hospital interviewed to explore the medicinal use of Huangteng in the screen edge of ethnic minority areas firstly and found its detoxification and anti-inflammatory effect of antibacterial. Then, it was promoted to be used in Yunnan province after the initial clinical validation.
Palmatine on the market is mostly natural, which is mainly obtained from the extraction of dry rattan of Huangteng, one plant of Menispermaceae. The palmatine is abundant in the dry rattan of Huangteng with more than 2% palmatine chloride . It is an important part of technological research to obtain natural palmatine with high quality and high purity
Honghe state in Yunnan province isolated and extracted palmatine from Huangteng firstly and then produced needle, tablets, ointment and topical solution, and other dosage forms for the treatment of various suppurative infections. It is now believed that the optimum conditions for the extraction of palmatine should be acid water decocting, firstly extracted from the rattan of Huangteng and then adjusted to pH 9-10, and NaCl salting out, which is obtained by precipitation purifica tion step by step, while ultrasonic can be used as an auxiliary means of extraction.
The growth period of Huangteng is very long so that the extraction of natural palmatine cannot meet the market demand. Therefore, in order to alleviate the con tradiction of resources, researchers began to explore the method of chemical synthe sis of palmatine and its active derivatives in place of natural palmatine. At present, the improved synthetic method using berberine as raw material is the one with high yield, the total yield of which is 54%, and the purity of palmatine is 99%

Indications

Palmatine is included in the Pharmacopoeia of the People’s Republic of China (2015). As an antibacterial drug, palmatine is used to treat upper respiratory tract infections, tonsillitis, enteritis, dysentery, urinary tract infections, surgical and gynecological bacterial infections such as inflammation, and so on. Locally, it can treat conjunctivitis when dropping eyes and Candida albicans infection when used in vaginal topically

Pharmacology

Palmatine is a detoxification agent with a variety of pharmacological effects.
Broad-spectrum antimicrobial antiviral effect: It can inhibit the activity of West Nile virus NS2B-NS3 protein, the Asian influenza A virus, dengue virus, and yellow fever virus. Also, it has an inhibitory effect on a variety of Gram-positive and Gram-negative bacteria, especially on fungi. Palmatine inhibits the proliferation of the Cordyceps epidermis and other 12 kinds of fungi to different degrees and has a good effect on shallow or deep infection caused by Candida albicans.
Enhance the ability of leukocyte phagocytosis: 0.3 mL/100 g, once/day, a total of 10 days of intraperitoneal injection can enhance the macrophage phagocytosis func tion. Palmatine has a different degree of prophylactic or therapeutic effect on rat adjuvant arthritis when orally administered with suspension prepared by 0.5% car boxymethylcellulose for 9 days on dose of 0.5 mg/100 g. Palmatine can partially counter allergy caused by trichosanthin, and its anti-inflammatory effects may be related to the immune mechanism. Studies have shown that palmatine can improve cellular immunity, humoral immunity, and non-specific immune function
Insect resistance: Palmatine has a significant anti-Trichomonas vaginalis activity in vitro; the anti-vaginal trichomonas activity is equivalent to metronidazole, with seven different concentrations (20, 10, 5, 2.5, 1.25, 0.625, and 0.3125 μg/mL) and different times (2–48 h).
Cardiovascular system: Palmatine can protect myocardial infarction, having a slight excitement on the frog heart and antiarrhythmic effect. It can also lower blood pressure when injecting intravenously anesthetized rabbits.
In addition, the palmatine also showed an inhibition of central nervous function. However, the mechanism of pharmacological mechanism of brassinone is still not clear and need further studies

Clinical Use

Palmatine has an effect of detoxification; therefore, it is used mainly for gynecologi cal inflammation, such as acute and chronic pelvic inflammatory disease, acute and chronic annex inflammation, cervical erosion, endometritis, mycoplasma vaginitis, puerperal infection, bacillary dysentery, enteritis, urinary tract infection, surgical infection, conjunctivitis, respiratory tract infections, and so on.
At present, palmatine has achieved some curative effect in combination therapy, but the small amount of adverse reactions of palmatine preparations in clinical treat ment cannot be ignored, such as allergic reactions and symptoms of catarr

References

Feist, Sandstede., Arch. Pharm., 256, 1 (1918)
Spath, Quietensky., Ber., 58,2267 (1925)
Haworth, Koepfli, Perkin., J. Chem. Soc., 548 (1927)
Feist, Awe, Etzrodt., Chem. Zentr., I, 2374 (1935)
Spath, Meinhard., Ber., 75,400 (1942)

Palmatine Preparation Products And Raw materials

Raw materials

Preparation Products

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Palmatine Suppliers

Guangzhou Shunyi Pharmaceutical Chemical Co., Ltd.
Fax
QQ:1506687511
Email
jasontim@shuntongchem.cn;jasontim@shuntongchem.cn
Country
China
ProdList
40
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9222
Advantage
58
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
Advantage
65
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8925
Advantage
52
China Langchem Inc.
Tel
0086-21-58956006;021-38701807;021-58950017
Fax
0086-21-58956100
Country
China
ProdList
7833
Advantage
57
Hubei YuanCheng Pharmaceutical Co., Ltd.
Tel
18062666904
Fax
QQ:2355880546
Email
wyy01@ycphar.com
Country
China
ProdList
670
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2976
Advantage
58
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View Lastest Price from Palmatine manufacturers

Dideu Industries Group Limited
Product
Palmatine USP/EP/BP 3486-67-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Palmatine 3486-67-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Palmatine 3486-67-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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