Swertiamarine

Product Name: Swertiamarine
CAS No.: 17388-39-5
Chemical Name: Swertiamarine
Synonyms: SWERTIAMARIN;Swertimarin;SWERTIAMAIN;Swertiamaroside;[4aR-(4aα,5β,6α)]-5-Ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one;Swertiamari;Wertiamarin;Swertamarin;Swertiamarine;SWERTIAMARIN(P)
CBNumber: CB6470993
Molecular Formula: C16H22O10
Formula Weight: 374.34
MOL File: 17388-39-5.mol

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Swertiamarine Property

Melting point:: 113-114°
alpha: D20 -127° (c = 1 in 96% ethanol)
Boiling point:: 649.3±55.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO : 250 mg/mL (667.84 mM; Need ultrasonic)
form: Solid
pka: 11.56±0.60(Predicted)
color: White to Yellow to Orange
λmax: 238nm(MeOH)(lit.)
Merck: 14,9010
BRN: 55278
Stability:: Hygroscopic
InChIKey: HEYZWPRKKUGDCR-QBXMEVCASA-N
CAS DataBase Reference: 17388-39-5(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: UQ1366700
HS Code: 29389090
Toxicity: mouse,LD50,intraperitoneal,> 8gm/kg (8000mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00080
Product name: Swertiamarin
Purity: ≥95% (LC/MS-ELSD)
Packaging: 1mg
Price: $324
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89513
Product name: Swertiamarine
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $416
Updated: 2025/07/31

Sigma-Aldrich

Product number: 90957
Product name: Swertiamarin
Purity: analytical standard
Packaging: 10mg
Price: $342
Updated: 2025/07/31

TCI Chemical

Product number: S0897
Product name: Swertiamarin
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 27634
Product name: Swertiamarin
Packaging: 10mg
Price: $121
Updated: 2024/03/01

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Swertiamarine Chemical Properties,Usage,Production

Chemical Properties

White crystals, soluble in water, methanol, ethanol, almost insoluble in chloroform, ether, petroleum ether, from long-stalked Gentiana macrophylla (Tibet) when the medicine, swertia, green leaf urchin, fritillary.

Uses

Swertimarine is an extract from Enicostemma littorale which is an herb used in the treatment of type 1 and 2 diabetes. Used to sensitize the cells to hypolipidemic conditions and insulin.

Definition

ChEBI: Swertiamarin is a glycoside.

Biological Activity

Swertiamarin has shown potential as antiatherogenic agent by inhibiting HMG-CoA reductase activity in high cholesterol fed rats. The high cholesterol fed rats treated with Swertiamarin showed prevention of increased serum total cholesterol, triglycerides, LDLs and VLDLs.

in vivo

Swertiamarin (50, 75 mg/kg; once daily; 7 days; p.o.) has a lipid-lowering effect in hypercholesterolemic rats^[1]. Swertiamarin (100, 200 mg/kg; once daily; 8 weeks; i.g.) has antioxidant and hepatoprotective effects on carbon tetrachloride induced rat hepatotoxicity through the Nrf2/HO-1 pathway^[2]. Swertiamarin (2, 5, 10 mg/kg; once daily; 2 weeks; p.o.) prevents bone erosion in arthritis rats by regulating RANKL/RANK/OPG signaling transduction^[3]. Swertiamarin (2, 5, 10 mg/kg; once daily; 2 weeks; p.o.) attenuates inflammatory mediators by regulating NF - κ B/I, κ B, and JAK2/STAT3 transcription factors in adjuvant induced arthritis rats^[4].

Animal Model:	Male Sprague Dawley (SD) rats with hypercholesterolemia induced by supplementing a diet rich in cholesterol^[1].
Dosage:	50, 75 mg/kg
Administration:	Oral gavage (p.o.); once daily; 7 days
Result:	Reduced serum total cholesterol, triglyceride concentration and atherosclerosis index.

Animal Model:	Male Sprague Dawley (SD) rat model of liver injury induced by CCl₄^[2].
Dosage:	100, 200 mg/kg
Administration:	i.g. ; once daily; 8 weeks
Result:	Reduced the levels of serum marker enzymes ALT, AST, and ALP representing liver damage, and restored antioxidant enzyme activity and GSH content in rat liver.

Animal Model:	Induced arthritis rat model by intradermal injection of 0.1ml Freund's complete adjuvant (FCA) in 1ml paraffin oil into the right hind paw of rats^[3]^[4].
Dosage:	2, 5, 10 mg/kg
Administration:	Oral gavage (p.o.); once daily; 2 weeks
Result:	Reduced calcium and TRAP, ACP, and ALP levels in serum and urine of arthritis rats, and increased phosphorus and collagen levels^[3]. Inhibited paw thickness, lysosomal enzyme levels, and increased body weight in rats^[4].

Swertiamarine Preparation Products And Raw materials

Raw materials

Preparation Products

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Swertiamarine Suppliers

China 305 Germany 2 India 3 Japan 3 United Kingdom 7 United States 24 Global 344

Henan Huaguang Biology

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Nanjing Dasf Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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Adamas Reagent, Ltd.

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China DongFan Chemical Co.,LTD

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View Lastest Price from Swertiamarine manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Swertiamarine 17388-39-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 30%; 50%; 98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-23

Sinoway Industrial co., ltd.

Product: Swertiamarine 17388-39-5
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 0.99
Supply Ability: 20 tons
Release date: 2024-06-27

Shanghai Standard Technology Co., Ltd.

Product: Swertiamarin 17388-39-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-25

17388-39-5, SwertiamarineRelated Search:

VINYL PROPIONATE Palmatine DL-Octopamine hydrochloride Asiaticoside BAVACHININ A Isochlorogenic Acid B AURANTIO-OBTUSIN CHLOROPHOSPHONAZO III Sweroside Tetrahydropyran Vinyltrimethoxysilane Triethoxyvinylsilane Amygdalin Tetrahydro-4H-pyran-4-one Gentiopicroside Oleuropein Viscidulin III tetraacetate methyl N,N,N-trimethyl-4-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-2-ylidene)methyl]anilinium sulphate

(4ar-(4a-alpha,5-beta,6-alpha))-ranosyloxy)-4a-hydroxy

1h,3h-pyrano(3,4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopy

1H,3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.alpha.-hydroxy-,[4ar-(4.alpha.-.alpha.,5-.beta.,D-.alpha.)]-

3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.1H

Swertiamari

4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosyloxy)-4a-hydroxy-3h-pyrano(1

glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-,(4aR,5R, 6S)-

Swertiamarin(6CI,7CI,8CI)

Swertiamarine

Swertiamaroside

SWERTIAMAIN

SWERTIAMARIN

SWERTIAMARIN, 98+% BY HPLC

Swertiamarin std.

SWERTIAMARIN(P)

(5R,6S)-5-Ethenyl-4a-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[5,4-c]pyran-1-one

(3S,4R,4aR)-4-ethenyl-4a-hydroxy-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-3,4,5,6-tetrahydropyrano[3,4-c]pyran-8-one

Swertiamarin，Swertiamarine，Swertiamaroside

[4aR-(4aα,5β,6α)]-5-Ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one

1H,3H-Pyrano[3,4-c]pyran-1-one,5-ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-,(4aR,5R,6S)-

(4aR,5R,6S)-5-Ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy1H,3H-pyrano[3,4-c]pyran-1-one

4,4a,5,6-Tetrahydro-4aα-hydroxy-1-oxo-5β-vinyl-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside

(4aR)-4aα-Hydroxy-5β-vinyl-6α-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one

4aα-Hydroxy-6α-(β-D-glucopyranosyloxy)-5β-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one

6α-(β-D-Glucopyranosyloxy)-4,4a,5,6-tetrahydro-4aα-hydroxy-5β-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one

Wertiamarin

Swertiamarin, 98%, from Swertia bimaculata (Sieb. & Zucc.) Hook.f. & Thoms. ex C. B. Clarke

Swertia chirata leaves extracts

Swertiamarin Standard

Swertiamarin &gt

Swertiamarin RS

1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)-

Swertia Extract

Swertiamarine USP/EP/BP

Swertimarin

(3S,4R,4aR)-4-ethenyl-4a-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[3,4-c]pyran-8-one

Swertiamarin(17388-39-5)

(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one

Swertamarin

Swertiamarine-RM

Swertiamarin, 10 mM in DMSO

17388-39-5

1738-39-5

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Sugars, Carbohydrates & Glucosides