GINKGETIN

Product Name: GINKGETIN
CAS No.: 481-46-9
Chemical Name: GINKGETIN
Synonyms: GINKGETIN;ginkgotin;Ginkgetin-RM;Ginkgetin, >98%;GINKGETIN USP/EP/BP;Ginkgetin, 10 mM in DMSO;GINKGETIN(RG)(PLEASE CALL);Ginkgetin, 98%, from Ginkgo biloba L.;4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
CBNumber: CB8350301
Molecular Formula: C32H22O10
Formula Weight: 566.51
MOL File: 481-46-9.mol

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GINKGETIN Property

Melting point:: 297 °C(Solv: acetone (67-64-1))
Boiling point:: 863.7±65.0 °C(Predicted)
Density: 1.506±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:64.0(Max Conc. mg/mL);112.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.21(Max Conc. mM)
pka: 6.18±0.40(Predicted)
form: powder
color: Light yellow
InChIKey: AIFCFBUSLAEIBR-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(O)C=C2)OC2=C(C3=CC(C4OC5=CC(OC)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1
LogP: 4.450 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25103
Product name: Ginkgetin
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 25103
Product name: Ginkgetin
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 25103
Product name: Ginkgetin
Purity: ≥98%
Packaging: 10mg
Price: $239
Updated: 2024/03/01

Usbiological

Product number: 300333
Product name: Ginkgetin
Packaging: 10mg
Price: $433
Updated: 2021/12/16

AK Scientific

Product number: Y0086
Product name: Ginkgetin
Packaging: 10mg
Price: $353
Updated: 2021/12/16

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GINKGETIN Chemical Properties,Usage,Production

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from Ginkgo biloba.

Uses

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

Definition

ChEBI: A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxyge ase 2.

in vivo

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway^[4].
Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice^[5].

Animal Model:	Male Sprague-Dawley rats (200-220 g)^[4]
Dosage:	25, 50, 100 mg/kg
Administration:	I.p. 2 hours after the onset of ischemia
Result:	Reduced the neurological de?cit score. Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα. Decreased the expressions of ICAM-1, COX-2, and iNOS. Downregulated downstream in?ammatory factor PGE2 and TNF-α expression. Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.

References

[1] Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. DOI:10.3390/cancers11121828
[2] Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. DOI:10.1007/s13659-015-0056-4
[3] Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. DOI:10.3892/or.2015.4427
[4] Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. DOI:10.1080/09168451.2018.1553608
[5] Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. DOI:10.18632/oncotarget.21862

GINKGETIN Preparation Products And Raw materials

Raw materials

Preparation Products

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GINKGETIN Suppliers

China 165 Germany 1 Japan 1 United States 19 Global 186

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3842
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
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View Lastest Price from GINKGETIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ginkgetin 481-46-9
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-12

Shanxi Naipu Import and Export Co.,Ltd

Product: GINKGETIN 481-46-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/month
Release date: 2021-10-19

Hebei shuoxi biotechnology co. LTD

Product: Ginkgetin 481-46-9
Price: US $82.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 20tons
Release date: 2019-10-22

481-46-9, GINKGETINRelated Search:

Ginkgolic acid Ginkgolide A Ginkgolide B Ginkgolide C Ginkgo biloba extract TREMELLA FUCIFORMIS POLYSACCHARIDE Ginkgolic acid (13:0) 6-pentadecylsalicylic acid Ginkgolic Acid C17:1 Ginkgolic Acid C17:2 Ginkgolide J N-BUTYLISOCYANIDE Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE Tris(2,4-pentanedionato)chroMiuM(III) Aluminum acetylacetonate SALCOMINE TERT-BUTYL ISOCYANIDE

GINKGETIN

4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone

5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Ginkgetin, >98%

5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

GINKGETIN(RG)(PLEASE CALL)

4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-

Ginkgetin, 98%, from Ginkgo biloba L.

GINKGETIN USP/EP/BP

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one

anti-tumor,Autophagy,biloba,anti-fungal,Ginkgo,signaling,Wnt,neuroprotective,inhibit,Apoptosis,leaves,anti-inflammatory,biflavone,Ginkgetin,Inhibitor

5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-chromen-4-one

ginkgotin

Ginkgetin-RM

Ginkgetin, 10 mM in DMSO

481-46-9