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AMENTOFLAVONE

Product Name
AMENTOFLAVONE
CAS No.
602-06-2
Chemical Name
AMENTOFLAVONE
Synonyms
skyrin;Skirin;Endothianin;Rhodophyscin;3',8''-BIAPIGENIN;I3,II8 BIAPIGENIN;DIDEMETHYL-GINKGETIN;4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE;(+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthraquinone;2,4,5,2',4',5'-hexahydroxy-7,7'-dimethyl-[1,1']bianthryl-9,10,9',10'-tetraone
CBNumber
CB6744025
Molecular Formula
C30H18O10
Formula Weight
538.46
MOL File
602-06-2.mol
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AMENTOFLAVONE Property

Melting point:
>380℃
Boiling point:
956.1±65.0 °C(Predicted)
Density 
1.698±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble
pka
5.24±0.20(Predicted)
form 
A crystalline solid
color 
Orange to dark red
biological source
Penicillium islandicum
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0459
Product name
Skyrin
Purity
≥98% (HPLC)
Packaging
1mg
Price
$254
Updated
2025/07/31
Cayman Chemical
Product number
13102
Product name
Skyrin
Purity
≥97%
Packaging
1mg
Price
$183
Updated
2024/03/01
Usbiological
Product number
045303
Product name
Skyrin
Packaging
1mg
Price
$375
Updated
2021/12/16
TRC
Product number
S555053
Product name
Skyrin
Packaging
1mg
Price
$165
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CN2-0001-M001
Product name
Skyrin
Purity
≥97%(HPLC)
Packaging
1mg
Price
$150
Updated
2021/12/16
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AMENTOFLAVONE Chemical Properties,Usage,Production

Uses

Skyrin is a non-peptidic anthraquinone, mycotoxin.

Definition

ChEBI: Skyrin is a biaryl and a trihydroxyanthraquinone. It is functionally related to an emodin.

Biological Activity

Skyrin is a non-peptidic anthraquinone, mycotoxin with in vitro cytotoxic activity. It suppresses the growth of HeLa, Vero, K562, Raji, Wish and Calu-1 cell lines. Skyrin treatment induces DNA fragmentation and other morphological changes leading to apoptosis in Human HL-60 promyelotic leukemia cells. Skyrin was found to serve as an anti-diabetic agent by selectively binding to the glucagon receptor acting as its antagonist. Regular binding of glucagon to its receptor on hepathocyte plasma membrane activates adenylate cyclase indirectly. As a result, the cAMP produced activates protein kinase A with a consequent increase in both glycogen breakdown and gluconeogenesis leading to glucose output. Skyrin was shown to block this signal transduction sequence, such th at the interaction of glucagons with its receptor does not result in an increase in cAMP production. Skyrin was also found to efficiently scavenge free radical species as ?OH, ?R and of singlet oxygen (1O2). Based on Skyrin selective toxicity towards insect cell line Sf9, it may be useful as an agent for pest control.

storage

+4°C

AMENTOFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMENTOFLAVONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Skyrin 602-06-2
Price
US $0.10-0.10/G
Min. Order
1G
Purity
98%min
Supply Ability
20KG
Release date
2025-08-14

602-06-2, AMENTOFLAVONERelated Search:

Protocatechuic acid Triptolide Quercetin Carthamus Tinctorius L. P.E. Hypericin Catalpol Kaempferol GINKGETIN Sciadopitysin Amentoflavone 4',4''',7''-trimethyl ether AMENTOFLAVONE-4'''-METHYL ETHER,AMENTOFLAVONE-4''-METHYL ETHER Amentoflavone Amentoflavone 4''',7,7''-trimethyl ether Amentoflavone 1- Amino-cyclopropane-1-acid hydrochloride amentoflavone hexaacetate AMENTOFLAVONE-4'-METHYL ETHER Amentoflavone 7,4',7'',4'''-tetramethyl ether

  • 4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE
  • 3',8''-BIAPIGENIN
  • DIDEMETHYL-GINKGETIN
  • I3,II8 BIAPIGENIN
  • Endothianin
  • Skirin
  • skyrin
  • (+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthracene-9,9',10,10'-tetrone
  • (+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthraquinone
  • Rhodophyscin
  • 2,4,5,2',4',5'-hexahydroxy-7,7'-dimethyl-[1,1']bianthryl-9,10,9',10'-tetraone
  • [1,1'-Bianthracene]-9,9',10,10'-tetrone, 2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-, (1S)-
  • 602-06-2
  • Biochemicals and Reagents
  • BioChemical
  • Natural Dyes