ChemicalBook > CAS DataBase List > 2'-METHYLPHENACYL BROMIDE

2'-METHYLPHENACYL BROMIDE

Product Name
2'-METHYLPHENACYL BROMIDE
CAS No.
51012-65-8
Chemical Name
2'-METHYLPHENACYL BROMIDE
Synonyms
AKOS BBS-00004007;Zolpidem Impurity 21;2-(Bromoacetyl)toluene;2-METHYLPHENACYL BROMIDE;2'-METHYLPHENACYL BROMIDE;2-Methyl phenycyl Bromide;2-Bromo-1-o-tolyl-ethanone;2-bromo-2-methylacetophenone;Zolpidem tartrate Impurity 15;2-Bromo-2'-methylacetophenone
CBNumber
CB8227690
Molecular Formula
C9H9BrO
Formula Weight
213.07
MOL File
51012-65-8.mol
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2'-METHYLPHENACYL BROMIDE Property

Boiling point:
82
Density 
1.416±0.06 g/cm3(Predicted)
refractive index 
1.5790 to 1.5830
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
color 
Light yellow to Yellow to Orange
Water Solubility 
Slightly soluble in water.
Sensitive 
Lachrymatory
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Safety

Hazard Codes 
Xi
RIDADR 
UN 2810 6.1/PG III
Hazard Note 
Irritant/Lachrymator
HazardClass 
6.1
PackingGroup 
III
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4750
Product name
2-Bromo-2'-methylacetophenone
Purity
>96.0%(GC)(T)
Packaging
200mg
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
B4750
Product name
2-Bromo-2'-methylacetophenone
Purity
>96.0%(GC)(T)
Packaging
1g
Price
$85
Updated
2025/07/31
TRC
Product number
B700663
Product name
2-Bromo-1-(o-tolyl)ethanone
Packaging
500mg
Price
$90
Updated
2021/12/16
Apolloscientific
Product number
OR11269
Product name
2-Methylphenacylbromide
Packaging
1g
Price
$54
Updated
2021/12/16
AK Scientific
Product number
W6612
Product name
2'-Methylphenacylbromide
Packaging
1g
Price
$61
Updated
2021/12/16
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2'-METHYLPHENACYL BROMIDE Chemical Properties,Usage,Production

Uses

2-Bromo-2'-methylacetophenone is an aromatic building block for proteomics research.

Synthesis

933-88-0

18107-18-1

51012-65-8

Example 6 Preparation of 2-bromo-1-o-tolylacetophenone (I15): 2-methylbenzoyl chloride (169 μL, 1.29 mmol) was dissolved in anhydrous acetonitrile (5 mL) under nitrogen protection and cooled to 0°C. Subsequently, (diazomethyl)-trimethylsilane (1.94 mL, 3.88 mmol, 2 M hexane solution) was slowly added. The reaction mixture was stirred at room temperature for 15 h. The reaction mixture was again cooled to 0 °C and 48% hydrobromic acid (512 μL, 4.53 mmol) was slowly added. The reaction mixture was continued to be stirred at room temperature for 3 hours. After completion of the reaction, the organic layer was separated by adding ethyl acetate (EtOAc) and water for extraction. The aqueous phase was neutralized with 1 M sodium hydroxide (NaOH) and extracted again with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford 2-bromo-1-o-toluene ethanone (250 mg, 91% yield). The intermediate could be used for subsequent reactions without further purification.1H NMR (300 MHz, DMSO-d6) δ ppm: 7.82-7.91 (m, 1H), 7.45-7.52 (m, 1H), 7.25-7.40 (m, 2H), 4.86 (s, 2H), 2.41 (s, 3H).

References

[1] Patent: US2011/311458, 2011, A1
[2] Patent: WO2011/161018, 2011, A1. Location in patent: Page/Page column 35

2'-METHYLPHENACYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-METHYLPHENACYL BROMIDE Suppliers

Americas 1 China 100 Europe 3 Germany 2 India 6 Japan 1 United Kingdom 3 United States 10 Global 126
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51012-65-8, 2'-METHYLPHENACYL BROMIDERelated Search:

4-METHYLPHENACYL BROMIDE Methyl 2-hydroxy-2-methoxyacetate 6-METHYL-N,N-DIMETHYL-2-(4-METHYLPHENYL)-2-HYDROXYIMIDAZO[1,2-ALPHA]PYRIDINE-3-ACETAMIDE Zolpidem Impurity 17 ZOLPIDEM IMPURITY A Zolpidem Impurity 23 2-Keto ZolpideM 2-bromo-1-(3-bromo-4-methyl-phenyl)-ethanone methyl 4-methylpiperazine-1-carboxylate 2,2-DIBROMO-1-P-TOLYLETHANONE RP 48497 (Eszopiclone Impurity C) ZOPICLONE N-OXIDE Zolpidem Impurity 29 Zolpidem Impurity 18 Ethanamine, 2-[(8-chloro-5-oxidodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- Zonisamide N,N-Dimethylformimidamide Deschloro-Zopiclone tetramethyloxamide

  • 2-Methyl phenycyl Bromide
  • 2-Bromo-2'-methylacetophenone, 2-Bromo-1-(2-methylphenyl)ethan-1-one, 2-Bromo-1-(o-tolyl)ethan-1-one
  • 2'-METHYLPHENACYL BROMIDE
  • 2-METHYLPHENACYL BROMIDE
  • AKOS BBS-00004007
  • 2-bromo-2-methylacetophenone
  • 2-Bromo-1-o-tolyl-ethanone
  • 2-bromo-1-(2-methylphenyl)ethanone
  • Ethanone, 2-bromo-1-(2-methylphenyl)-
  • Zolpidem Impurity 21
  • 2-Bromo-2'-methylacetophenone &gt
  • 2-Bromo-2'-methylacetophenone,98%
  • 2-(Bromoacetyl)toluene
  • Zolpidem tartrate Impurity 15
  • 2-Bromo-1-(o-tolyl)ethan-1-one
  • 2-Bromo-2'-methylacetophenone
  • 51012-65-8