CANDOXATRIL

Product Name: CANDOXATRIL
CAS No.: 123122-55-4
Chemical Name: CANDOXATRIL
Synonyms: UK-79300;candoxatril;Candoxatril (UK 79300);Candoxatril [usan:inn:ban];4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
CBNumber: CB82280992
Molecular Formula: C29H41NO7
Formula Weight: 515.63834
MOL File: 123122-55-4.mol

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CANDOXATRIL Property

Melting point:: 107-109°
alpha: D -5.8° (c = 1 in methanol)
Boiling point:: 718.4±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.84±0.25(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C175200
Product name: Candoxatril
Packaging: 10mg
Price: $7425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007547
Product name: CANDOXATRIL
Purity: 95.00%
Packaging: 10MG
Price: $8373.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007547
Product name: CANDOXATRIL
Purity: 95.00%
Packaging: 1MG
Price: $2769.9
Updated: 2021/12/16

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CANDOXATRIL Chemical Properties,Usage,Production

Uses

Neutral endopeptidase inhibitor. Used in treatment of congestive heart failure.

Uses

Neutral endopeptidase inhibitor. Candoxatril is used in treatment of congestive heart failure.

Definition

ChEBI: The 2,3-dihydro-1H-inden-5-yl ester of the active enantiomer of candoxatrilat. Candoxatril is an orally active prodrug of candoxatrilat, a potent neutral endopeptidase (NEP, neprilysin) inhibitor used in the treatment of chronic heart fa lure.

in vivo

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor^[2].

CANDOXATRIL Preparation Products And Raw materials

Raw materials

Preparation Products

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CANDOXATRIL Suppliers

Canada 1 China 23 India 3 United States 4 Global 31

Chemsky (shanghai) International Co.,Ltd

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123122-55-4, CANDOXATRILRelated Search:

4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid

UK-79300

Candoxatril [usan:inn:ban]

Candoxatril (UK 79300)

Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-

candoxatril

cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid

123122-55-4

C29H41NO7

Aromatics

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Inhibitors

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