CANDOXATRIL
- Product Name
- CANDOXATRIL
- CAS No.
- 123122-55-4
- Chemical Name
- CANDOXATRIL
- Synonyms
- UK-79300;candoxatril;Candoxatril (UK 79300);Candoxatril [usan:inn:ban];4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
- CBNumber
- CB82280992
- Molecular Formula
- C29H41NO7
- Formula Weight
- 515.63834
- MOL File
- 123122-55-4.mol
CANDOXATRIL Property
- Melting point:
- 107-109°
- alpha
- D -5.8° (c = 1 in methanol)
- Boiling point:
- 718.4±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.84±0.25(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- C175200
- Product name
- Candoxatril
- Packaging
- 10mg
- Price
- $7425
- Updated
- 2021/12/16
- Product number
- API0007547
- Product name
- CANDOXATRIL
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $8373.75
- Updated
- 2021/12/16
- Product number
- API0007547
- Product name
- CANDOXATRIL
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $2769.9
- Updated
- 2021/12/16
CANDOXATRIL Chemical Properties,Usage,Production
Uses
Neutral endopeptidase inhibitor. Used in treatment of congestive heart failure.
Uses
Neutral endopeptidase inhibitor. Candoxatril is used in treatment of congestive heart failure.
Definition
ChEBI: The 2,3-dihydro-1H-inden-5-yl ester of the active enantiomer of candoxatrilat. Candoxatril is an orally active prodrug of candoxatrilat, a potent neutral endopeptidase (NEP, neprilysin) inhibitor used in the treatment of chronic heart fa lure.
in vivo
While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].
CANDOXATRIL Preparation Products And Raw materials
Raw materials
Preparation Products
CANDOXATRIL Suppliers
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