ChemicalBook > CAS DataBase List > FMRF AMIDE

FMRF AMIDE

Product Name
FMRF AMIDE
CAS No.
152165-14-5
Chemical Name
FMRF AMIDE
Synonyms
FMRF-NH2;FMRF AMIDE;PHE-MET-ARG-PHE-NH2;PHE-MET-ARG-PHE AMIDE;H-PHE-MET-ARG-PHE-NH2;FMRFAMIDE ACETATE SALT;FMRF-AMIDE 1 1/2ACOH 2H2O;H-PHE-MET-ARG-PHE-NH2 ACOH;PHE-MET-ARG-PHE-NH2: FMRF-NH2;H-Phe-Met-Arg-Phe-NH2 acetate
CBNumber
CB8231121
Molecular Formula
C29H42N8O4S
Formula Weight
598.76
MOL File
152165-14-5.mol
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FMRF AMIDE Property

storage temp. 
−20°C
Sequence
Phe-Met-Arg-Phe-NH2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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FMRF AMIDE Chemical Properties,Usage,Production

Uses

Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1].

in vivo

Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].

References

[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0

FMRF AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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152165-14-5, FMRF AMIDERelated Search:

FMRF-AMIDE LIKE PEPTIDE 1 (LOBSTER),FMRF AMIDE-LIKE PEPTIDE I, LOBSTER FMRF amide (Nle-Arg-Phe-NH2) FMRF amide (Phe-Met-Arg-Phe) FMRF amide-like Peptide II (lobster) (Thr-Asn-Arg-Asn-Phe-Leu-Arg-Phe-NH2) FMRF amide (Tyr-Phe-Met-Arg-Phe-NH2) FMRF amide (Ac-Phe-Nle-Arg-Phe-NH2) FMRF amide (Phe-Met-Arg-Phe-NH2) (Molluscan Cardioexcitatory Neuropeptide) FMRF amide (AF-2) (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) FMRF amide (AF-1) (Lys-Asn-Glu-Phe-Ile-Arg-Phe-NH2) FMRF amide (Phe-Leu-Arg-Arg) H-TYR-PHE-MET-ARG-PHE-NH2 [D-MET2]-FMRF-AMIDE FMRF amide (Trp-Nle-Arg-Phe-NH2) FMRF amide (Met-Arg-Phe) H-TYR-GLY-GLY-PHE-MET-ARG-PHE-NH2 TYR-MET-ARG-PHE-NH2 FMRF AMIDE FMRF amide [D-Phe4] (Phe-Met-Arg-D-Phe-NH2)

  • PHE-MET-ARG-PHE AMIDE
  • PHE-MET-ARG-PHE-NH2
  • PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
  • MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE ACETATE SALT
  • H-PHE-MET-ARG-PHE-NH2
  • H-PHE-MET-ARG-PHE-NH2 ACETATE SALT
  • H-PHE-MET-ARG-PHE-NH2 ACOH
  • FMRF-NH2
  • FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • FMRF AMIDE
  • FMRF-AMIDE 1 1/2ACOH 2H2O
  • FMRFAMIDE ACETATE SALT
  • PHE-MET-ARG-PHE-NH2: FMRF-NH2
  • H-Phe-Met-Arg-Phe-NH2 acetate
  • 152165-14-5
  • C31H46N8O6S
  • Invertebrate Neuropeptides
  • Other Neuropeptides
  • Peptides
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Peptide