CALYCULIN A

ChemicalBook > CAS DataBase List > CALYCULIN A

Product Name: CALYCULIN A
CAS No.: 101932-71-2
Chemical Name: CALYCULIN A
Synonyms: C05370;CALYCULIN A;(-)-CALYCULIN A;Calyculin A ((-)-Calyculin A);CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
CBNumber: CB8233130
Molecular Formula: C50H81N4O15P
Formula Weight: 1009.17
MOL File: 101932-71-2.mol

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CALYCULIN A Property

Melting point:: 247-249°
alpha: D -60° (c = 0.1 in ethanol)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble
form: solid
pka: 1.81±0.10(Predicted)
color: white
Water Solubility: Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Merck: 13,1731
BRN: 4903216

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-38
Safety Statements: 36/37/39-45
RIDADR: UN 3462 6.1/PG 3
WGK Germany: 3
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5552
Product name: Calyculin A from Discodermia calyx
Purity: ≥90% (HPLC), solid
Packaging: 10μg
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08226
Product name: InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
Packaging: 5μg
Price: $126
Updated: 2024/03/01

Sigma-Aldrich

Product number: 21279
Product name: Calyculin A from Discodermia calyx
Purity: ≥90% (HPLC)
Packaging: 10μg
Price: $307
Updated: 2024/03/01

Sigma-Aldrich

Product number: 208851
Product name: Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
Purity: Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC?? = 0.5-1 nM) and protein phosphatase 1 (PP1; IC?? = 2 nM).
Packaging: 10μg
Price: $216
Updated: 2024/03/01

Alfa Aesar

Product number: J61952
Product name: Calyculin A, 98+%
Packaging: 100microg
Price: $531
Updated: 2021/12/16

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CALYCULIN A Chemical Properties,Usage,Production

Uses

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

Uses

Calyculin A from Discodermia calyx has been used:

as an inhibitor of serine-threonine protein phosphatase 2A
as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

Uses

Inhibitor of phosphatases 1 and 2a.

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C

CALYCULIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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CALYCULIN A Suppliers

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101932-71-2, CALYCULIN ARelated Search:

MICROCYSTIN-LR OKADAIC ACID POTASSIUM SALT OKADAIC ACID SODIUM SALT MICROCYSTIN YR NODULARIN TAUTOMYCIN OKADAIC ACID AMMONIUM SALT OKADAIC ACID CALYCULIN A DRY ICE calyculin B Calyculin A (Serine/Threonine Phosphatase Inhibitor) Methyl-2-deoxy-alpha-D-ribofuranoside CALYCULIN A

C05370

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide

CALYCULIN A

CALYCULIN A, DISCODERMIA CALYX

calyculin A from discodermia calyx

CALYCULIN A FROM DISCODERMIA CALYX, 10 U G

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o

(-)-CALYCULIN A

Calyculin A ((-)-Calyculin A)

InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

L-Ribonamide, N-(3S)-3-4-(1E)-3-(2R,3R,5R,7S,8S,9R)-2-(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro4.5dec-7-yl-1-propenyl-2-oxa

L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimet...

101932-71-2

C50H81N4O15P

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Protein Phosphatase 1 (PP1)

Serine/Threonine Phosphatase Substrates

Serine/Threonine Phosphatase Inhibitors

Kinase/Phosphatase Biology

Serine/Threonine Kinase Biology

Protein phosphatase-1, Catalytic SubunitCancer Research

Tumor Promotors

Cell Signaling and Neuroscience

P to

Phosphatase InhibitorsSerine/Threonine Kinase Biology

Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme

Serine/Threonine Phosphatase Inhibitors

Tumor Growth Regulation

Inhibitor

Serine/Threonine Phosphatase Substrates