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CALYCULIN A

Product Name
CALYCULIN A
CAS No.
101932-71-2
Chemical Name
CALYCULIN A
Synonyms
C05370;CALYCULIN A;(-)-CALYCULIN A;Calyculin A ((-)-Calyculin A);CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;Calyculin A, Discodermia calyx;Calyculin A from Discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;Calyculin A, protein phosphatase inhibitor
CBNumber
CB8233130
Molecular Formula
C50H81N4O15P
Formula Weight
1009.17
MOL File
101932-71-2.mol
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CALYCULIN A Property

Melting point:
247-249°
alpha 
D -60° (c = 0.1 in ethanol)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
pka
1.81±0.10(Predicted)
color 
white
biological source
sea sponge (Discodermia calyx)
optical activity
+59.815 (Ethanol)
Water Solubility 
Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Merck 
13,1731
BRN 
4903216
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-38
Safety Statements 
36/37/39-45
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
F 
8-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5552
Product name
Calyculin A from Discodermia calyx
Purity
≥90% (HPLC), solid
Packaging
10μg
Price
$215.65
Updated
2025/07/31
Sigma-Aldrich
Product number
5.08226
Product name
InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
Packaging
5μg
Price
$130
Updated
2025/07/31
Sigma-Aldrich
Product number
21279
Product name
Calyculin A from Discodermia calyx
Purity
≥90% (HPLC)
Packaging
10μg
Price
$316
Updated
2025/07/31
Sigma-Aldrich
Product number
208851
Product name
Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
Purity
Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC?? = 0.5-1 nM) and protein phosphatase 1 (PP1; IC?? = 2 nM).
Packaging
10μg
Price
$222
Updated
2025/07/31
Cayman Chemical
Product number
19246
Product name
Calyculin A
Purity
≥99%
Packaging
10μg
Price
$141
Updated
2024/03/01
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CALYCULIN A Chemical Properties,Usage,Production

Uses

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

Uses

Calyculin A from Discodermia calyx has been used:

  • as an inhibitor of serine-threonine protein phosphatase 2A
  • as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
  • as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

Uses

Inhibitor of phosphatases 1 and 2a.

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C

CALYCULIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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101932-71-2, CALYCULIN ARelated Search:

MICROCYSTIN-LR OKADAIC ACID POTASSIUM SALT OKADAIC ACID SODIUM SALT MICROCYSTIN YR NODULARIN TAUTOMYCIN OKADAIC ACID AMMONIUM SALT OKADAIC ACID CALYCULIN A DRY ICE calyculin B Calyculin A (Serine/Threonine Phosphatase Inhibitor) Methyl-2-deoxy-alpha-D-ribofuranoside CALYCULIN A

  • C05370
  • N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
  • CALYCULIN A
  • CALYCULIN A, DISCODERMIA CALYX
  • calyculin A from discodermia calyx
  • CALYCULIN A FROM DISCODERMIA CALYX, 10 U G
  • N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
  • N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o
  • (-)-CALYCULIN A
  • Calyculin A ((-)-Calyculin A)
  • InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
  • Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
  • L-Ribonamide, N-(3S)-3-4-(1E)-3-(2R,3R,5R,7S,8S,9R)-2-(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro4.5dec-7-yl-1-propenyl-2-oxa
  • L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimet...
  • Calyculin A, protein phosphatase inhibitor
  • Calyculin A from <i>Discodermia calyx</i>
  • Calyculin A, <i>Discodermia calyx</i>
  • 101932-71-2
  • C50H81N4O15P
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Protein Phosphatase 1 (PP1)
  • Serine/Threonine Phosphatase Substrates
  • Serine/Threonine Phosphatase Inhibitors
  • Kinase/Phosphatase Biology
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Biology
  • Protein phosphatase-1, Catalytic SubunitCancer Research
  • Tumor Promotors
  • Cell Signaling and Neuroscience
  • P to
  • Phosphatase InhibitorsSerine/Threonine Kinase Biology
  • Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme
  • Serine/Threonine Phosphatase Inhibitors
  • Tumor Growth Regulation
  • Inhibitor
  • Serine/Threonine Phosphatase Substrates