ChemicalBook > CAS DataBase List > 1-IODO-3,4-METHYLENEDIOXYBENZENE

1-IODO-3,4-METHYLENEDIOXYBENZENE

Product Name
1-IODO-3,4-METHYLENEDIOXYBENZENE
CAS No.
5876-51-7
Chemical Name
1-IODO-3,4-METHYLENEDIOXYBENZENE
Synonyms
5-Iodobenzo[d][1,3]dioxole;5-Iodine Pepper Ring;5-IODO-1,3-BENZODIOXOLE;1,3-Benzodioxole, 5-iodo-;2-iodo-5-nitrobenzenamine;5-iodo-2H-1,3-benzodioxole;3,4-Methylenedioxyiodobenzene;5-Iodo-2-methylbenzotrifluoride;1-IODO-3,4-METHYLENEDIOXYBENZENE;4-Iodo-1,2-(Methylenedioxy)benzene
CBNumber
CB8241649
Molecular Formula
C7H5IO2
Formula Weight
248.02
MOL File
5876-51-7.mol
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1-IODO-3,4-METHYLENEDIOXYBENZENE Property

Boiling point:
94 °C
Density 
1,91 g/cm3
Flash point:
111℃
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform, Methanol
form 
Oil
color 
Brown
CAS DataBase Reference
5876-51-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-52-41-37/38
Safety Statements 
26-36/37/39-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TCI Chemical
Product number
I1251
Product name
5-Iodobenzo[d][1,3]dioxole
Purity
min. 98.0 %
Packaging
1G
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
I1251
Product name
5-Iodobenzo[d][1,3]dioxole
Purity
min. 98.0 %
Packaging
5G
Price
$162
Updated
2025/07/31
TRC
Product number
I708400
Product name
1-Iodo-3,4-methylenedioxybenzene
Packaging
2.5g
Price
$100
Updated
2021/12/16
SynQuest Laboratories
Product number
2H10-H-01
Product name
1-Iodo-3,4-methylenedioxybenzene
Purity
99%
Packaging
5G
Price
$149
Updated
2021/12/16
SynQuest Laboratories
Product number
2H10-H-01
Product name
1-Iodo-3,4-methylenedioxybenzene
Purity
99%
Packaging
1g
Price
$63
Updated
2021/12/16
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1-IODO-3,4-METHYLENEDIOXYBENZENE Chemical Properties,Usage,Production

Chemical Properties

Brown Oil

Uses

1-Iodo-3,4-methylenedioxybenzene is an iodinated benzodioxole used in the preparation of various biologically active compounds such as the antiviral and antitumor agents.

Synthesis

274-09-9

5876-51-7

N-iodosuccinimide (14.8 g, 66.0 mmol), 1,3-benzodioxole (6.31 mL, 55.0 mmol) and acetic acid (470 mL) were added to a 1 L flask under argon protection. The reaction mixture was stirred at room temperature for 65 hours. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure and the residue was neutralized with saturated aqueous sodium bicarbonate solution. Subsequently, aqueous sodium thiosulfate and chloroform were added to the reaction mixture to separate the organic layer. The aqueous layer was further extracted with chloroform. All organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using hexane as eluent to afford 5-iodo-1,3-benzodioxole (11.3 g, 45.7 mmol, 83% yield) in colorless liquid form.

References

[1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 1, p. 77 - 82
[2] Patent: JP2015/163597, 2015, A. Location in patent: Paragraph 0167; 0168
[3] Synthesis, 1995, # 10, p. 1273 - 1277
[4] Catalysis Science and Technology, 2014, vol. 4, # 12, p. 4308 - 4312
[5] Tetrahedron Letters, 1987, vol. 28, # 41, p. 4879 - 4882

1-IODO-3,4-METHYLENEDIOXYBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-IODO-3,4-METHYLENEDIOXYBENZENE Suppliers

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View Lastest Price from 1-IODO-3,4-METHYLENEDIOXYBENZENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
1-IODO-3,4-METHYLENEDIOXYBENZENE 5876-51-7
Price
US $80.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-27
Career Henan Chemical Co
Product
1-IODO-3,4-METHYLENEDIOXYBENZENE 5876-51-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-03-13

5876-51-7, 1-IODO-3,4-METHYLENEDIOXYBENZENERelated Search:

6-iodo-1,3-benzodioxole-5-carboxylic acid 1-IODO-3,4-METHYLENEDIOXYBENZENE 5,6-DIIODOBENZO(1,3)DIOXOLE 2,2-DIFLUORO-5-AMINO-6-IODO-1,3-BENZODIOXOLE 5-IODO-6-NITRO-1,3-BENZODIOXOLE

  • 5-IODO-1,3-BENZODIOXOLE
  • 1-IODO-3,4-METHYLENEDIOXYBENZENE
  • 5-Iodo-2-methylbenzotrifluoride
  • 1-IODO-3,4-METHYLENEDIOXYBENZENE 99%
  • 5-iodo-2H-1,3-benzodioxole
  • 3,4-Methylenedioxyiodobenzene
  • 4-Iodo-1,2-(Methylenedioxy)benzene
  • 5-Iodobenzo[d][1,3]dioxole
  • 2-iodo-5-nitrobenzenamine
  • 1,3-Benzodioxole, 5-iodo-
  • 5-Iodine Pepper Ring
  • 5876-51-7
  • 5IO2
  • Aromatics
  • Heterocycles
  • Intermediates
  • Heterocycles series
  • Iodine Compounds
  • Miscellaneous Compounds
  • Aromatic Hydrocarbons (substituted) & Derivatives