2-BROMO-5-METHOXYPHENOL
- Product Name
- 2-BROMO-5-METHOXYPHENOL
- CAS No.
- 63604-94-4
- Chemical Name
- 2-BROMO-5-METHOXYPHENOL
- Synonyms
- 2-BROMO-5-METHOXYPHENOL;4-Bromo-3-hydroxyanisole;2-bromine-5-methoxyphenol;Phenol, 2-bromo-5-methoxy-;2-Bromo-5-methoxyphenol 98%;1-bromo-2-hydroxy-4-methoxy benzene
- CBNumber
- CB8241917
- Molecular Formula
- C7H7BrO2
- Formula Weight
- 203.03
- MOL File
- 63604-94-4.mol
2-BROMO-5-METHOXYPHENOL Property
- Melting point:
- 152 °C
- Boiling point:
- 253.3±20.0 °C(Predicted)
- Density
- 1.585±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 8.05±0.10(Predicted)
- color
- Light brown to pink
- InChI
- InChI=1S/C7H7BrO2/c1-10-5-2-3-6(8)7(9)4-5/h2-4,9H,1H3
- InChIKey
- KHGMUWBYGFWGCZ-UHFFFAOYSA-N
- SMILES
- C1(O)=CC(OC)=CC=C1Br
Safety
- HS Code
- 2909500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B696773
- Product name
- 2-Bromo-5-methoxyphenol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B696773
- Product name
- 2-Bromo-5-methoxyphenol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B696773
- Product name
- 2-Bromo-5-methoxyphenol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB139627
- Product name
- 2-Bromo-5-methoxyphenol
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 067083
- Product name
- 2-Bromo-5-methoxyphenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
2-BROMO-5-METHOXYPHENOL Chemical Properties,Usage,Production
Synthesis
150-19-6
63604-94-4
102127-34-4
40.0 g (322.2 mmol) of 3-methoxyphenol was dissolved in 1 L of acetonitrile and cooled to 0 °C under nitrogen protection. A solution of 57.35 g (322.2 mmol) of N-bromosuccinimide in 500 mL of acetonitrile was added slowly dropwise, with the rate of dropwise acceleration being controlled to maintain the temperature of the reaction mixture at 0 °C (for about 2 hours). After titration was completed, the reaction mixture was continued to be stirred at 0 °C for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was treated with carbon tetrachloride and filtered to remove the resulting solid. The filtrate was concentrated under reduced pressure to give a mixture of brominated isomers in the form of a red oil. The mixture was separated by silica gel column chromatography using a hexane gradient elution system containing 0-30% ethyl acetate. The first eluted fractions were collected and concentrated under reduced pressure to give 18.1 g (28% yield) of 2-bromo-5-methoxyphenol as a clear liquid.1H-NMR (CDCl3): δ 7.31 (d, 1H), 6.6 (d, 1H), 6.41 (dd, 1H), 5.5 (s, 1H), 3.77 (s, 3H). Subsequently, the post-eluted fractions were combined and concentrated under reduced pressure. The residue was further purified by silica gel column chromatography using dichloromethane as eluent. The fraction containing high purity 4-bromo-3-methoxyphenol was collected and concentrated under reduced pressure to give 24.1 g (37% yield) of white crystalline solid (melting point 68-69 °C).1H-NMR (CDCl3): δ 7.34 (d, 1H), 6.45 (d, 1H), 6.33 (dd, 1H), 4.9 (br s, 1H), 3.85 (s, 3H).
References
[1] Synlett, 1997, vol. 1997, # 11, p. 1241 - 1242
[2] Patent: US7045545, 2006, B1. Location in patent: Page/Page column 19
[3] Patent: EP1204659, 2003, B1. Location in patent: Page/Page column 14
[4] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 622 - 627
2-BROMO-5-METHOXYPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-METHOXYPHENOL manufacturers
- Product
- 2-BROMO-5-METHOXYPHENOL 63604-94-4
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04