2-BROMO-5-METHOXYPHENOL

Product Name: 2-BROMO-5-METHOXYPHENOL
CAS No.: 63604-94-4
Chemical Name: 2-BROMO-5-METHOXYPHENOL
Synonyms: 2-BROMO-5-METHOXYPHENOL;4-Bromo-3-hydroxyanisole;2-bromine-5-methoxyphenol;Phenol, 2-bromo-5-methoxy-;2-Bromo-5-methoxyphenol 98%;1-bromo-2-hydroxy-4-methoxy benzene
CBNumber: CB8241917
Molecular Formula: C7H7BrO2
Formula Weight: 203.03
MOL File: 63604-94-4.mol

More

Less

2-BROMO-5-METHOXYPHENOL Property

Melting point:: 152 °C
Boiling point:: 253.3±20.0 °C(Predicted)
Density: 1.585±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 8.05±0.10(Predicted)
color: Light brown to pink
InChI: InChI=1S/C7H7BrO2/c1-10-5-2-3-6(8)7(9)4-5/h2-4,9H,1H3
InChIKey: KHGMUWBYGFWGCZ-UHFFFAOYSA-N
SMILES: C1(O)=CC(OC)=CC=C1Br

More

Less

Safety

HS Code: 2909500090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B696773
Product name: 2-Bromo-5-methoxyphenol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696773
Product name: 2-Bromo-5-methoxyphenol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B696773
Product name: 2-Bromo-5-methoxyphenol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139627
Product name: 2-Bromo-5-methoxyphenol
Packaging: 1g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 067083
Product name: 2-Bromo-5-methoxyphenol
Purity: 97%
Packaging: 1g
Price: $40
Updated: 2021/12/16

More

Less

2-BROMO-5-METHOXYPHENOL Chemical Properties,Usage,Production

Synthesis

150-19-6

63604-94-4

102127-34-4

40.0 g (322.2 mmol) of 3-methoxyphenol was dissolved in 1 L of acetonitrile and cooled to 0 °C under nitrogen protection. A solution of 57.35 g (322.2 mmol) of N-bromosuccinimide in 500 mL of acetonitrile was added slowly dropwise, with the rate of dropwise acceleration being controlled to maintain the temperature of the reaction mixture at 0 °C (for about 2 hours). After titration was completed, the reaction mixture was continued to be stirred at 0 °C for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was treated with carbon tetrachloride and filtered to remove the resulting solid. The filtrate was concentrated under reduced pressure to give a mixture of brominated isomers in the form of a red oil. The mixture was separated by silica gel column chromatography using a hexane gradient elution system containing 0-30% ethyl acetate. The first eluted fractions were collected and concentrated under reduced pressure to give 18.1 g (28% yield) of 2-bromo-5-methoxyphenol as a clear liquid.1H-NMR (CDCl3): δ 7.31 (d, 1H), 6.6 (d, 1H), 6.41 (dd, 1H), 5.5 (s, 1H), 3.77 (s, 3H). Subsequently, the post-eluted fractions were combined and concentrated under reduced pressure. The residue was further purified by silica gel column chromatography using dichloromethane as eluent. The fraction containing high purity 4-bromo-3-methoxyphenol was collected and concentrated under reduced pressure to give 24.1 g (37% yield) of white crystalline solid (melting point 68-69 °C).1H-NMR (CDCl3): δ 7.34 (d, 1H), 6.45 (d, 1H), 6.33 (dd, 1H), 4.9 (br s, 1H), 3.85 (s, 3H).

References

[1] Synlett, 1997, vol. 1997, # 11, p. 1241 - 1242
[2] Synlett, 1997, vol. 1997, # 11, p. 1241 - 1242
[3] Patent: US7045545, 2006, B1. Location in patent: Page/Page column 19
[4] Patent: EP1204659, 2003, B1. Location in patent: Page/Page column 14
[5] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 622 - 627

2-BROMO-5-METHOXYPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-BROMO-5-METHOXYPHENOL Suppliers

China 144 Germany 1 India 3 United Kingdom 3 United States 14 Global 165

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Chontech, Inc.

Tel: --
Fax: --
Email: chontech@yahoo.com
Country: United States
ProdList: 1101
Advantage: 30

More

Less

View Lastest Price from 2-BROMO-5-METHOXYPHENOL manufacturers

Career Henan Chemical Co

Product: 2-BROMO-5-METHOXYPHENOL 63604-94-4
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

63604-94-4, 2-BROMO-5-METHOXYPHENOLRelated Search:

2-BROMO-5-METHOXYBENZONITRILE 3-BROMO-2,6-DIMETHOXYBENZOIC ACID 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZAMIDE 1,5-Dibromo-2,4-dimethoxybenzene Acid Red 87 ETHYL EOSIN 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN 1-Bromo-2,4-dimethoxybenzene 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID Solvent Red 43 TETRABROMOFLUORESCEIN POTASSIUM SALT 2-BROMO-4-METHOXYPHENOL 2-AMINO-6-BROMO-4-METHOXYPHENOL 5- BROMO-2-METHOXYPHENOL 4-BROMO-2-METHOXYPHENOL 4-BROMO-3-METHOXYPHENOL 2-Bromo-6-methoxyphenol, 98+% MERBROMIN

2-Bromo-5-methoxyphenol 98%

4-Bromo-3-hydroxyanisole

2-BROMO-5-METHOXYPHENOL

Phenol, 2-bromo-5-methoxy-

1-bromo-2-hydroxy-4-methoxy benzene

2-bromine-5-methoxyphenol

63604-94-4

blocks

Bromides