ChemicalBook > CAS DataBase List > N-(P-TOLUENESULFONYL)-L-PHENYLALANINE

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE

Product Name: N-(P-TOLUENESULFONYL)-L-PHENYLALANINE
CAS No.: 13505-32-3
Chemical Name: N-(P-TOLUENESULFONYL)-L-PHENYLALANINE
Synonyms: TOSYL-L-PHENYLALANINE;TOS-PHE-OH;Tos-Phe;Tos-L-Phe;os-Phe-OH;Ts-Phe-OH;Tos-L-Phe-OH;TOS-PHENYLALANINE-OH;N-TOSYL-L-PHENYLALANINE;P-TOSYL-L-PHENYLALANINE
CBNumber: CB8243128
Molecular Formula: C16H17NO4S
Formula Weight: 319.38
MOL File: 13505-32-3.mol

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N-(P-TOLUENESULFONYL)-L-PHENYLALANINE Property

Melting point:: 165 °C
Boiling point:: 517.7±60.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
refractive index: -2.8 ° (C=4.5, Acetone)
storage temp.: Sealed in dry,Room Temperature
solubility: almost transparency in hot EtOH
form: powder to crystal
pka: 3.31±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C16H17NO4S/c1-12-7-9-14(10-8-12)22(20,21)17-15(16(18)19)11-13-5-3-2-4-6-13/h2-10,15,17H,11H2,1H3,(H,18,19)/t15-/m0/s1
InChIKey: CGRCVIZBNRUWLY-HNNXBMFYSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=CC=C1)NS(C1=CC=C(C)C=C1)(=O)=O
CAS DataBase Reference: 13505-32-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1443
Product name: N-(p-Toluenesulfonyl)-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 10g
Price: $25
Updated: 2022/04/27

TCI Chemical

Product number: T1443
Product name: N-(p-Toluenesulfonyl)-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: T1443
Product name: N-(p-Toluenesulfonyl)-L-phenylalanine
Packaging: 5G
Price: $42
Updated: 2025/07/31

TRC

Product number: T631620
Product name: N-(p-Toluenesulfonyl)-L-phenylalanine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 291469
Product name: Tosyl-L-phenylalanine
Packaging: 25g
Price: $340
Updated: 2021/12/16

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N-(P-TOLUENESULFONYL)-L-PHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Synthesis

63-91-2

98-59-9

13505-32-3

GENERAL STEPS: Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added dropwise to an aqueous solution (15 mL) of L-phenylalanine (12.5 mmol) under continuous stirring conditions until complete dissolution. Subsequently, the reaction system was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was slowly added in four portions over 1 hour. The reaction mixture was continued to be stirred at room temperature for 4 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was methanol/dichloromethane, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The precipitated solid was collected by diafiltration and washed with pH 2.2 buffer. Finally, the purified product (S)-2-(4-methylphenylsulfonamido)-3-phenylpropionic acid was placed in a desiccator and dried using fused silica gel as desiccant.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760
[4] European Journal of Organic Chemistry, 2005, # 5, p. 934 - 938
[5] Journal of Organic Chemistry, 2012, vol. 77, # 9, p. 4375 - 4384

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(P-TOLUENESULFONYL)-L-PHENYLALANINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3
Price: US $20.00-5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-28

Career Henan Chemical Co

Product: N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-26

13505-32-3, N-(P-TOLUENESULFONYL)-L-PHENYLALANINERelated Search:

TOS-LYS(BOC)-OH N-(p-Tolylsulphonyl)-L-glutamic acid TOS-PRO-OH N-P-TOSYLGLYCINE SALOR-INT L173339-1EA TOS-ALA-OH P-TOLUENESULFONYL-L-PHENYLALANINE CHLOROMETHYL KETONE P-TOLUENESULFONYL-L-PHENYLALANINE CHLOROMETHYL KETONE,NALPHA-(4-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone N-Propyl-P-Toluenesulfonamide N-phenethylmethanesulphonamide (S)-(-)-N-[1-(HYDROXYMETHYL)-2-PHENYLETHYL]-4-METHYLBENZENESULFONAMIDE N-(2-hydroxyethyl)benzenesulfonamide 2-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID N-(P-TOLUENESULFONYL)-L-PHENYLALANINE BSMOC-TYROSINE BSMOC-PHENYLALANINE

N-P-TOSYL-L-PHENYLALANINE 97%

N-alpha-p-Toluolsulfonyl-L-phenylalanine

Tos-L-Phe-OH

TOSYL-L-PHENYLALANINE

TOS-PHENYLALANINE-OH

TOS-PHE-OH

P-TOSYL-L-PHENYLALANINE

N-TOSYL-L-PHENYLALANINE

N-P-TOSYL-L-PHENYLALANINE

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE

Tos-L-Phe

N-tosyl-(S)-phenylalanine

(2S)-2-(4-methylbenzenesulfonamido)-3-phenylpropanoic acid

2-{[(4-methylphenyl)sulfonyl]amino}-3-phenylpropanoic acid

N-p-Toluenesulphonyl-L-phenylalanine

N-[(4-Methylphenyl)sulfonyl]phenylalanine

L-Phenylalanine, N-((4-methylphenyl)sulfonyl)-

N-((4-Methylphenyl)sulfonyl)-L-phenylalanine

Tos-Phe

(S)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoic acid

os-Phe-OH

Tosyl-L-phenylalanine≥ 98% (HPLC)

2-[(4-methylphenyl)sulfonylamino]-3-phenyl-propionic acid

N-(p-Toluenesulfonyl)-L-phenylalanine

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE USP/EP/BP

(2S)-2-[(4-methylphenyl)sulfonylamino]-3-phenylpropanoic acid

Factory supply N-(P-TOLUENESULFONYL)-L-PHENYLALANINE CAS 13505-32-3 high quality

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3

(S)-N-Tosylphenylalanine

Ts-Phe-OH

13505-32-3

C6H5CH2CHNHSO2C6H4CH3CO2H

CARBOXYLIC ACID

Amino Acid Derivatives

Amino Acids