4-N-BOC-AMINO-CYCLOHEXANOL

Product Name: 4-N-BOC-AMINO-CYCLOHEXANOL
CAS No.: 224309-64-2
Chemical Name: 4-N-BOC-AMINO-CYCLOHEXANOL
Synonyms: 4-(Boc-amino)cyclohexanol;N-4-Boc-aminocyclohexanol;4-N-BOC-AMINO-CYCLOHEXANOL;N-Boc-4-amino-cyclohexanol;tert-butyl cyclohexylcarbaMate;tert-Butyl 4-hydroxycyclohexylcarbaMate;4-(tert-Butoxycarbonylamino)cyclohexanol;4-(tert-Butoxycarbonylamino)cyclohexanol >4-(tert-Butoxycarbonylamino)cyclohexanol;1,1-Dimethylethyl N-(4-hydroxycyclohexyl)carbamate
CBNumber: CB8243810
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 224309-64-2.mol

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4-N-BOC-AMINO-CYCLOHEXANOL Property

Melting point:: 170.0 to 174.0 °C
Boiling point:: 337.7±31.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane, DMSO, Methanol
form: Solid
pka: 12.36±0.40(Predicted)
color: White
InChI: InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8-9,13H,4-7H2,1-3H3,(H,12,14)
InChIKey: DQARDWKWPIRJEH-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1CCC(O)CC1

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
HS Code: 2924.29.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00037
Product name: tert-Butyl N-(4-hydroxycyclohexyl)carbamate
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $179
Updated: 2025/07/31

TCI Chemical

Product number: B4714
Product name: 4-(tert-Butoxycarbonylamino)cyclohexanol
Purity: >98.0%(GC)(N)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B4714
Product name: 4-(tert-Butoxycarbonylamino)cyclohexanol
Purity: >98.0%(GC)(N)
Packaging: 5g
Price: $101
Updated: 2025/07/31

TRC

Product number: B690225
Product name: 4-[(tert-Butoxycarbonyl)amino]cyclohexanol(MixtureofDiastereomers)
Packaging: 250mg
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139932
Product name: tert-Butyl (4-hydroxycyclohexyl)carbamate
Packaging: 5G
Price: $190
Updated: 2021/12/16

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4-N-BOC-AMINO-CYCLOHEXANOL Chemical Properties,Usage,Production

Chemical Properties

White Solid

Synthesis Reference(s)

Chemistry Letters, 22, p. 1273, 1993
Tetrahedron Letters, 33, p. 2677, 1992 DOI: 10.1016/S0040-4039(00)79055-1

Synthesis

24424-99-5

6850-65-3

224309-64-2

General procedure: di-tert-butyl dicarbonate (4.087 mL, 21.01 mmol) and diisopropylethylamine (2.87 mL, 17.4 mmol) were dissolved in anhydrous THF (60 mL) under nitrogen protection. Subsequently, (1R,4R)-4-aminocyclohexanol (2.00 g, 17.4 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature (25°C) for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was concentrated to dryness in a rotary evaporator. The residue was dried overnight under high vacuum to afford 4-(Boc-amino)cyclohexanol as a white solid (3.49 g, 87.0% yield). The product could be used in subsequent reactions without further purification.

References

[1] Patent: WO2017/100662, 2017, A1. Location in patent: Page/Page column 103; 123
[2] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 48-49
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 2017 - 2021
[4] Patent: US5516806, 1996, A
[5] Patent: WO2013/107291, 2013, A1. Location in patent: Page/Page column 63; 64

4-N-BOC-AMINO-CYCLOHEXANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-N-BOC-AMINO-CYCLOHEXANOL Suppliers

Americas 1 Canada 2 China 102 Europe 2 India 4 Japan 1 Russia 1 United Kingdom 1 United States 17 Global 131

Bengbu Nako Chemical Co., Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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View Lastest Price from 4-N-BOC-AMINO-CYCLOHEXANOL manufacturers

Career Henan Chemical Co

Product: 4-N-BOC-AMINO-CYCLOHEXANOL 224309-64-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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224309-64-2

Intermediates

Miscellaneous Reagents

N-BOC

Amines

blocks