1-BOC-6-BROMO-INDAZOLE

Product Name: 1-BOC-6-BROMO-INDAZOLE
CAS No.: 877264-77-2
Chemical Name: 1-BOC-6-BROMO-INDAZOLE
Synonyms: 1-BOC-6-BROMO-1H-INDAZOLE;6-Bromo-1H-indazole, N1-BOC protected;tert-butyl 6-bromoindazole-1-carboxylate;6-Bromo-1H-indazole-1-carboxylic acid tert-butyl ester;Tert-Butyl 6-broMo-1H-indazole-1-carboxylate C12H13BrN2O2;1H-Indazole-1-carboxylic acid, 6-broMo-, 1,1-diMethylethyl ester
CBNumber: CB82448530
Molecular Formula: C12H13BrN2O2
Formula Weight: 297.15
MOL File: 877264-77-2.mol

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1-BOC-6-BROMO-INDAZOLE Property

Boiling point:: 377℃
Density: 1.46
Flash point:: 182℃
storage temp.: 2-8°C
form: solid
color: White

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B695335
Product name: tert-Butyl6-Bromo-1H-indazole-1-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-T8
Product name: 6-Bromo-1H-indazole, N1-Boc protected
Packaging: 1g
Price: $61
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51395
Product name: 1-Boc-6-bromo-indazole
Packaging: 100mg
Price: $78
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51395
Product name: 1-Boc-6-bromo-indazole
Packaging: 250mg
Price: $97.5
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-T8
Product name: 6-Bromo-1H-indazole, N1-Boc protected
Packaging: 100mg
Price: $20
Updated: 2021/12/16

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1-BOC-6-BROMO-INDAZOLE Chemical Properties,Usage,Production

Synthesis

79762-54-2

24424-99-5

877264-77-2

a) A suspension of 6-bromo-1H-indazole (82.74 mmol), 4-dimethylaminopyridine (DMAP, 16.55 mmol), and triethylamine (Et3N, 19.56 mL) in acetonitrile (CH3CN) was slowly added to an acetonitrile solution of di-tert-butyl dicarbonate (82.74 mmol) over a period of 15 min at 0°C, keeping the internal temperature no more than 5°C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent: 7% ethyl acetate/petroleum ether) to afford tert-butyl 6-bromo-1H-indazole-1-carboxylate (23.2 g, 94% yield) as a white solid.

References

[1] Patent: WO2012/37298, 2012, A1. Location in patent: Page/Page column 49
[2] Patent: WO2013/28445, 2013, A1. Location in patent: Page/Page column 54; 55
[3] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2016/57834, 2016, A1. Location in patent: Paragraph 000198

1-BOC-6-BROMO-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-6-BROMO-INDAZOLE Suppliers

China 62 India 1 United Kingdom 2 United States 7 Global 72

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877264-77-2, 1-BOC-6-BROMO-INDAZOLERelated Search:

Benzoic acid, 6-bromo-2,3-dichloro-, 1,1-dimethylethyl ester tert-butyl 6-bromo-2,3-dichloroisonicotinate 1H-Indazole-3-carboxylic acid, 6-broMo-, 1,1-diMethylethyl ester 1-BOC-6-AMINO-INDAZOLE

1-BOC-6-BROMO-1H-INDAZOLE

6-Bromo-1H-indazole, N1-BOC protected

Tert-Butyl 6-broMo-1H-indazole-1-carboxylate C12H13BrN2O2

6-Bromo-1H-indazole-1-carboxylic acid tert-butyl ester

1H-Indazole-1-carboxylic acid, 6-broMo-, 1,1-diMethylethyl ester

tert-butyl 6-bromoindazole-1-carboxylate

877264-77-2

Indazoles