Pramipexole Impurity 16

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Pramipexole Impurity 16

Product Name: Pramipexole Impurity 16
CAS No.: 104632-27-1
Chemical Name: Pramipexole Impurity 16
Synonyms: RPPX;Kns 760704;Snd 919cl2x;Dexpramipexole HCl;Dexpramipexole 2HCl;Pramipexole R-Isomer;PraMipexole IMpurity D;Pramipexole BP Impurity D;Pramipexole impurity D CRS;KNS-760704 dihydrochloride
CBNumber: CB82449027
Molecular Formula: C10H18ClN3S
Formula Weight: 247.79
MOL File: 104632-27-1.mol

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Pramipexole Impurity 16 Property

storage temp.: -20°C
solubility: H2O: >15mg/mL
form: powder
color: white to beige
optical activity: [α]/D 60 to 70°, c = 1 in methanol

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2934200000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1553815
Product name: Pramipexole Related Compound D
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1210
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1824
Product name: Pramipexole Related Compound D
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50mg
Price: $675
Updated: 2022/05/15

Cayman Chemical

Product number: 18234
Product name: (R)-Pramipexole (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 18234
Product name: (R)-Pramipexole (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0392
Product name: Dexpramipexole dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $148
Updated: 2022/05/15

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Pramipexole Impurity 16 Chemical Properties,Usage,Production

Description

Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist. For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis. This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.

Uses

(R)-Pramipexole Dihydrochloride (Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D) is the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Pramipexole may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and ultraviolet spectrophotometry technique.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pramipexole Related Compound D is a pharmaceutical impurity of pramipexole. Pramipexole is a non-ergot dopamine receptor agonist, widely used in the treatment of Parkinson′s disease.

Biochem/physiol Actions

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.

Pramipexole Impurity 16 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pramipexole Impurity 16 manufacturers

Guangzhou PI PI BIOTECH INC

Product: Pramipexole Impurity D
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2020-06-01

104632-27-1, Pramipexole Impurity 16Related Search:

Aripiprazole Ethyl Pramipexole (S)-4,5,6,7-Tetrahydro-N2,N6-propionyl-2,6-benzothiazolediaMine (R)-Pramipexole 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone Pramipexole Impurity 18 BENZOOXAZOL-2-YLAMINE rac-trans-7-Hydroxy Pramipexole Pramipexole EP Impurity B DiHCl N6-propyl-3a,4,5,6,7,7a-hexahydrobenzo[d]thiazole-2,6-diamine 2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol Pramipexole impurity 7 Pramipexole (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine Pramipexole rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid 2-N-Propyl Pramipexole (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

(R)-PRAMIPEXOLE DIHYDROCHLORIDE; KNS 760704; SND 919CL2X

Pramipexole R-Isomer

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R)-

Kns 760704

Snd 919cl2x

DexpraMipexole (dihydrochloride)

PraMipexole IMpurity D

(R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride

(R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride

RPPX

Pramipexole Dihydrochloride Hydrate Impurity

(R)-Pramipexole (hydrochloride)

Pramipexole Dihydrochloride Hydrate IMP

Pramipexole EP Impurity D DiHCl

Pramipexole dihydrochloride impurity IV

(6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride

Dexpramipexole dihydrochloride ((R)-Pramipexole

Pramipexole impurity D CRS

KNS-760704 dihydrochloride

(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride

Dexpramipexole HCl

Pramipexole EP Impurity D ((R)-Pramipexole diHCl)

Pramipexole Related Compound D ((R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydro (1553815)

Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride

Dopamine Receptor,inhibit,Inhibitor,KNS-760704,Dexpramipexole,Dexpramipexole dihydrochloride,(R)-Pramipexole,KNS760704,KNS 760704

Pramipexole Impurity 4 Dihydrochloride（Pramipexole EP Impurity D Dihydrochloride）

Glycerol Impurity 41((R)-3-chloropropane-1,2-diol)

Dexpramipexole 2HCl

Pramipexole BP Impurity D

Pramipexole EP Impurity D HCl

104632-27-1

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