Pramipexole impurity 7
- Product Name
- Pramipexole impurity 7
- CAS No.
- 106092-09-5
- Chemical Name
- Pramipexole impurity 7
- Synonyms
- Pramipexole-1;PraMipexole IMpurity A;PraMipexole IMpurity C;Pramipexole impurity I;Pramipexole Impurity A1;Paramipexole Impurity-A;Pramipexole Intermediate 1;pramipexole impurities1162;(S)-N-Despropyl PraMipexole;PraMipexole Related CoMpound A
- CBNumber
- CB0276708
- Molecular Formula
- C7H11N3S
- Formula Weight
- 169.25
- MOL File
- 106092-09-5.mol
Pramipexole impurity 7 Property
- Melting point:
- 222-224°C
- Boiling point:
- 359.0±42.0 °C(Predicted)
- Density
- 1.313±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 9.18±0.20(Predicted)
- color
- White to Pale Beige
- optical activity
- Consistent with structure
- Stability:
- Light Sensitive
- InChI
- InChI=1/C7H11N3S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h4H,1-3,8H2,(H2,9,10)/t4-/s3
- InChIKey
- DRRYZHHKWSHHFT-BYPYZUCNSA-N
- SMILES
- NC1SC2C[C@@H](N)CCC=2N=1 |&1:5,r|
- CAS DataBase Reference
- 106092-09-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR2010
- Product name
- Pramipexole Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50mg
- Price
- $631.75
- Updated
- 2025/07/31
- Product number
- 757381
- Product name
- (S)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $85.6
- Updated
- 2023/06/20
- Product number
- D4337
- Product name
- (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- D4337
- Product name
- (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $263
- Updated
- 2025/07/31
- Product number
- 1553768
- Product name
- Pramipexole Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $1300
- Updated
- 2025/07/31
Pramipexole impurity 7 Chemical Properties,Usage,Production
Chemical Properties
Pale Beige Solid
Uses
(S)-Pramipexole intermediate as dopamine autoreceptor agonist.
Uses
(S)-N-Despropyl Pramipexole (Pramipexole EP Impurity A; Pramipexole BP Impurity A; Pramipexole USP Related Compound A) is a (S)-Pramipexole (P700755) intermediate as dopamine autoreceptor agonist.
Uses
(S)-N-Despropyl Pramipexole is a (S)-Pramipexole (P700745) intermediate as dopamine autoreceptor agonist.
Synthesis
106006-83-1
106092-09-5
General procedure for the synthesis of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole from 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole: First, 33.8 g of 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was mixed with 500 mL of water, followed by the addition of 30.0 g of L-(+)-tartaric acid. The reaction mixture was heated to 75°C and stirred for 1 hour. Thereafter, it was cooled to room temperature and stirring was continued for 24 hours. After completion of the reaction, filtration was carried out, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 hours to afford 35.1 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolium di-L-(+)-tartrate as crude product with an enantiomeric content of 2.53% (by chiral-HPLC determination). The entire crude product was redissolved in 500 mL of water, heated to 75°C and held for 1 hour, then cooled to room temperature and stirred for 24 hours. It was filtered again, washed with water and dried under the same vacuum conditions for 8-12 hours to give 26.9 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolyl di-L-(+)-tartrate with enantiomeric content reduced to 0.08%. Finally, the entire product was dissolved in a mixture of 200 mL of water and 40 mL of hydrochloric acid and stirred until completely dissolved. Subsequently, 35 drops of aqueous potassium hydroxide solution (mass percent is the ratio of potassium hydroxide to the total mass of the solution) were added to neutralize. The reaction mixture was cooled to room temperature and stirred for 1 h. The reaction mixture was filtered, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 h. The final product was 9.43 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole in a yield of 27.9% and enantiomeric content of 0.08%.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5501 - 5521
[2] Patent: CN108084115, 2018, A. Location in patent: Paragraph 0086; 0089
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 3, p. 494 - 498
[4] Patent: WO2011/21214, 2011, A2
[5] Investigational New Drugs, 2010, vol. 28, # 4, p. 454 - 465
Pramipexole impurity 7 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pramipexole impurity 7 manufacturers
- Product
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-20
- Product
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min
- Supply Ability
- 5MT
- Release date
- 2023-06-14
- Product
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11