PPT
- Product Name
- PPT
- CAS No.
- 263717-53-9
- Chemical Name
- PPT
- Synonyms
- PPT;-triyl)trisphenol;Propylpyrazole Triol;1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole;1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL;Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-;Estrogen Receptor/ERR,inhibit,Inhibitor,Propyl pyrazole triol
- CBNumber
- CB8245076
- Molecular Formula
- C24H22N2O3
- Formula Weight
- 386.44
- MOL File
- 263717-53-9.mol
PPT Property
- Melting point:
- 230 °C (decomp)
- Boiling point:
- 630.0±55.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 20 mg/mL, soluble
- form
- solid
- pka
- 8.80±0.15(Predicted)
- color
- off-white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H6036
- Product name
- 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 10008841
- Product name
- Propylpyrazole Triol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $21
- Updated
- 2024/03/01
- Product number
- 10008841
- Product name
- Propylpyrazole Triol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 10008841
- Product name
- Propylpyrazole Triol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $157
- Updated
- 2024/03/01
- Product number
- 10008841
- Product name
- Propylpyrazole Triol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $341
- Updated
- 2024/03/01
PPT Chemical Properties,Usage,Production
Uses
PPT is a potent and specific ERα agonist.
Definition
ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols.
General Description
Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.
Biological Activity
Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .
Biochem/physiol Actions
Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
storage
+4°C
PPT Preparation Products And Raw materials
Raw materials
Preparation Products
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