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PPT

Product Name
PPT
CAS No.
263717-53-9
Chemical Name
PPT
Synonyms
PPT;-triyl)trisphenol;Propylpyrazole Triol;1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole;1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL;Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-;Estrogen Receptor/ERR,inhibit,Inhibitor,Propyl pyrazole triol
CBNumber
CB8245076
Molecular Formula
C24H22N2O3
Formula Weight
386.44
MOL File
263717-53-9.mol
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PPT Property

Melting point:
230 °C (decomp)
Boiling point:
630.0±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 20 mg/mL, soluble
form 
solid
pka
8.80±0.15(Predicted)
color 
off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6036
Product name
1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
Purity
powder, ≥98% (HPLC)
Packaging
10mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
10008841
Product name
Propylpyrazole Triol
Purity
≥98%
Packaging
1mg
Price
$21
Updated
2024/03/01
Cayman Chemical
Product number
10008841
Product name
Propylpyrazole Triol
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
10008841
Product name
Propylpyrazole Triol
Purity
≥98%
Packaging
10mg
Price
$157
Updated
2024/03/01
Cayman Chemical
Product number
10008841
Product name
Propylpyrazole Triol
Purity
≥98%
Packaging
25mg
Price
$341
Updated
2024/03/01
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PPT Chemical Properties,Usage,Production

Uses

PPT is a potent and specific ERα agonist.

Definition

ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols.

General Description

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Biological Activity

Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .

Biochem/physiol Actions

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.

storage

+4°C

PPT Preparation Products And Raw materials

Raw materials

Preparation Products

263717-53-9, PPTRelated Search:


  • 4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL
  • 1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE
  • PPT
  • Propylpyrazole Triol
  • -triyl)trisphenol
  • Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-
  • 4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol
  • 1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole
  • Estrogen Receptor/ERR,inhibit,Inhibitor,Propyl pyrazole triol
  • 4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol
  • 263717-53-9
  • Intracellular receptor
  • Nuclear Receptors