N-CBZ-3-OXOAZETIDINE

Product Name: N-CBZ-3-OXOAZETIDINE
CAS No.: 105258-93-3
Chemical Name: N-CBZ-3-OXOAZETIDINE
Synonyms: 1-Cbz-3-azetidinone;N-CBZ-3-OXOAZETIDINE;1-Cbz-3-azetidinone - [C1509];Azetidin-3-one, N-CBZ protected;Benzyl 3-oxo-1-azetidinecarboxylate;1-(Benzyloxycarbonyl)azetidin-3-one;3-Oxo-azetidine-1-carboxylic acid benzyl ester;3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester;1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester;3-Oxo-azetidine-1-carboxylic acid benzyl ester 105258-93-3
CBNumber: CB82453341
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 105258-93-3.mol

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N-CBZ-3-OXOAZETIDINE Property

Melting point:: 40-44°
Boiling point:: 356.5±42.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.04±0.20(Predicted)
form: solid
color: White
InChI: InChI=1S/C11H11NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5H,6-8H2
InChIKey: VLMMTGKGDOAYER-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CC(=O)C1

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B194120
Product name: Benzyl3-Oxoazetidine-1-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Synthonix

Product number: C1509
Product name: 1-Cbz-3-azetidinone
Purity: 97.0%
Packaging: 5g
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: OR309040
Product name: Azetidin-3-one, N-CBZ protected
Purity: 97%
Packaging: 5g
Price: $33
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-40
Product name: Azetidin-3-one, N-Cbz protected
Packaging: 5G
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: X8749
Product name: Benzyl3-oxoazetidine-1-carboxylate
Packaging: 5g
Price: $41
Updated: 2021/12/16

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N-CBZ-3-OXOAZETIDINE Chemical Properties,Usage,Production

Synthesis

128117-22-6

105258-93-3

General procedure for the synthesis of 1-Benzyloxycarbonyl-3-hydroxyazetidin-3-one from 1-Benzyloxycarbonylazetidin-3-one: Triphenylmethyl-3-hydroxyazetidin-1-carboxylate (3.5 g, 0.0168 mol) was dissolved in dichloromethane (100 mL) at room temperature, followed by the addition of Dess-Martin periodinane (10.7 g, 0.025 mol). The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched with a 1:1 ratio of saturated aqueous sodium bicarbonate and 1 M sodium thiosulfate solution (200 mL). The mixture was extracted with dichloromethane and the organic layer was separated. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford phenylmethyl 3-oxoazetidine-1-carboxylate (3.43 g, 99% yield), the product was a clear, colorless oil, which did not require further purification. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.39-7.31 (m, 5H), 5.17 (s, 2H), 4.77 (s, 4H). Mass spectrometry (EI) analysis was consistent with the molecular weight of C11H11NO3: 205 (M+).

References

[1] Patent: WO2007/44515, 2007, A1. Location in patent: Page/Page column 165
[2] Patent: WO2008/76415, 2008, A1. Location in patent: Page/Page column 329
[3] Patent: WO2008/124085, 2008, A2. Location in patent: Page/Page column 179
[4] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 33; 34
[5] Patent: WO2013/8002, 2013, A1. Location in patent: Page/Page column 49

N-CBZ-3-OXOAZETIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-CBZ-3-OXOAZETIDINE Suppliers

China 139 Germany 1 India 4 United Kingdom 3 United States 10 Global 157

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
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Accela ChemBio Inc.

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Fax: (+1)-858-876-1948
Email: info@accelachem.com
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Alchem Pharmtech,Inc.

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Aladdin Scientific

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Synthonix Inc

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NE Scientific

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Combi-Blocks Inc.

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SynQuest Laboratories, Inc.

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Matrix Scientific

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Proactive Molecular Research

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View Lastest Price from N-CBZ-3-OXOAZETIDINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Cbz-3-azetidinone 105258-93-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-12

Hebei Chuanghai Biotechnology Co,.LTD

Product: Benzyl 3-Oxoazetidine-1-Carboxylate 105258-93-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-07-30

Henan Fengda Chemical Co., Ltd

Product: Benzyl 3-oxo-1-azetidinecarboxylate 105258-93-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

105258-93-3, N-CBZ-3-OXOAZETIDINERelated Search:

N-CBZ-3-OXOAZETIDINE

1-Cbz-3-azetidinone

3-Oxo-azetidine-1-carboxylic acid benzyl ester

1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester

Azetidin-3-one, N-CBZ protected

Benzyl 3-oxoazetidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-3-oxoazetidine

1-(Benzyloxycarbonyl)azetidin-3-one

3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester

3-Oxo-azetidine-1-carboxylic acid benzyl ester 105258-93-3

Benzyl 3-oxo-1-azetidinecarboxylate

1-Cbz-3-azetidinone - [C1509]

105258-93-3