ChemicalBook > CAS DataBase List > (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
- Product Name
- (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
- CAS No.
- 187665-65-2
- Chemical Name
- (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
- Synonyms
- PNU 142633;PNU142633,PNU 142633;(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE;1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-
- CBNumber
- CB82454328
- Molecular Formula
- C24H30N4O3
- Formula Weight
- 422.52
- MOL File
- 187665-65-2.mol
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Property
- Boiling point:
- 652.5±55.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble to 100 mM in DMSO
- form
- Powder
- pka
- 15.27±0.40(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Tocris
- Product number
- 1985
- Product name
- PNU142633
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $261
- Updated
- 2021/12/16
Usbiological
- Product number
- 256292
- Product name
- PNU 142633
- Packaging
- 10mg
- Price
- $516
- Updated
- 2021/12/16
TRC
- Product number
- P653455
- Product name
- PNU142633
- Packaging
- 1mg
- Price
- $140
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0024590
- Product name
- PNU-142633
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $965
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6906
- Product name
- PNU142633
- Packaging
- 10mg
- Price
- $385
- Updated
- 2021/12/16
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Chemical Properties,Usage,Production
Uses
PNU 142633 is a high affinity SR-1D agonist.
Biological Activity
Very selective, high affinity 5-HT 1D receptor agonist (K i values are 6 and > 18000 nM at human 5-HT 1D and 5-HT 1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo .
in vivo
PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds[1].
| Animal Model: | Male Hartley guinea pigs (250-300 g) stimulated with bipolar electrode[1] |
| Dosage: | 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg |
| Administration: | Intravenous injection |
| Result: | Significantly reduced extravasation at the 0.1 and 0.3 mg/kg doses, but was without effect at the 0.03 and 1.0 mg/kg doses. |
IC 50
5-HT1D Receptor: 6 nM (Ki)
storage
Store at +4°C
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE Suppliers
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