ChemicalBook > CAS DataBase List > D[LEU4,LYS8]-VP

D[LEU4,LYS8]-VP

Product Name: D[LEU4,LYS8]-VP
CAS No.: 42061-33-6
Chemical Name: D[LEU4,LYS8]-VP
Synonyms: D[LEU4,LYS8]-VP;(Deamino-Cys1,Leu?,Lys?)-Vasopressin;MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2;3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2;(Deamino-Cys?,Leu?,Lys?)-Vasopressin trifluoroacetate salt;Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-leucyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysyl-, cyclic (1→5)-disulfide;(Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
CBNumber: CB82456357
Molecular Formula: C47H67N11O11S2
Formula Weight: 1026.24
MOL File: 42061-33-6.mol

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D[LEU4,LYS8]-VP Property

Boiling point:: 1493.5±65.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 9.90±0.15(Predicted)
form: Powder
Water Solubility: Soluble to 2 mg/ml in water
Sequence: {Mpa}-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly (Disulfide bridge:Mpa1-Cys6)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3127
Product name: d[leu4,Lys8]-VP
Packaging: 1
Price: $335
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109910
Product name: (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
Packaging: 250ug
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109910
Product name: (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
Packaging: 500ug
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109910
Product name: (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
Packaging: 1mg
Price: $315
Updated: 2021/12/16

ApexBio Technology

Product number: B5383
Product name: d[Leu4,Lys8]-VP
Packaging: 1mg
Price: $497
Updated: 2021/12/16

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D[LEU4,LYS8]-VP Chemical Properties,Usage,Production

Uses

D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

References

[1] Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. DOI:10.1210/en.2006-1633
[2] Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47. DOI:10.1021/jm060928n

D[LEU4,LYS8]-VP Preparation Products And Raw materials

Raw materials

Preparation Products

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42061-33-6, D[LEU4,LYS8]-VPRelated Search:

3-MERCAPTOPROPIONYL-BETA-3-PYRIDYL-D-ALA-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, (DISULFIDE BOND) 3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2 Desmopressin (DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN (DEAMINO-CYS1,D-ORN8)-VASOPRESSIN (DEAMINO-CYS1,VAL4,D-ARG8)-VASOPRESSIN D[LEU4,LYS8]-VP

3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2

D[LEU4,LYS8]-VP

MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2

(Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)

(Deamino-Cys1,Leu?,Lys?)-Vasopressin

Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-leucyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysyl-, cyclic (1→5)-disulfide

(Deamino-Cys?,Leu?,Lys?)-Vasopressin trifluoroacetate salt

42061-33-6

C47H67N11O11S2