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ETHYL-L-NIO (HYDROCHLORIDE)

Product Name
ETHYL-L-NIO (HYDROCHLORIDE)
CAS No.
150403-97-7
Chemical Name
ETHYL-L-NIO (HYDROCHLORIDE)
Synonyms
ETHYL-L-NIO (HYDROCHLORIDE);DWNWLIPSWIUXRG-FJXQXJEOSA-N;L-N5-(1-IMINOBUTYL)ORNITHINE HYDROCHLORIDE;EthylLNIO (hydrochloride),Ethyl L NIO (hydrochloride);L-Ornithine, N5-(1-iminobutyl)-, monohydrochloride (9CI);chloro (2S)-2-amino-5-(1-aminobutylideneamino)pentanoate
CBNumber
CB82456377
Molecular Formula
C9H18ClN3O2
Formula Weight
0
MOL File
150403-97-7.mol
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ETHYL-L-NIO (HYDROCHLORIDE) Property

storage temp. 
Store at -20°C
solubility 
DMF: 0.3 mg/ml; DMSO: 2 mg/ml; Ethanol: 2.5 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10012088
Product name
Ethyl-L-NIO (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
10012088
Product name
Ethyl-L-NIO (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
10012088
Product name
Ethyl-L-NIO (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
10012088
Product name
Ethyl-L-NIO (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$733
Updated
2024/03/01
AK Scientific
Product number
1761AH
Product name
Ethyl-L-niohydrochloride
Packaging
100mg
Price
$912
Updated
2021/12/16
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ETHYL-L-NIO (HYDROCHLORIDE) Chemical Properties,Usage,Production

Description

Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 μM, respectively, as determined using initial rate measurements. However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 μM, respectively). Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.

Uses

Ethyl-L-NIO hydrochloride is a potent and competitive human dimethylarginine dimethylaminohydrolase 1 (hDDAH-1) inhibitor with an IC50 of 70 μM and a Ki of 32 μM[1].

References

[1] Kotthaus J, et al. Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DOI:10.1016/j.bmc.2008.10.058

ETHYL-L-NIO (HYDROCHLORIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL-L-NIO (HYDROCHLORIDE) Suppliers

China 15 United States 4 Global 19
Shanghai EFE Biological Technology Co., Ltd.
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TargetMol Chemicals Inc.
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Cayman Chemical Company
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800-364-9897
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sales@caymanchem.com
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150403-97-7, ETHYL-L-NIO (HYDROCHLORIDE)Related Search:

L(+)-Ornithine hydrochloride ETHYL-L-NIO (HYDROCHLORIDE) L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) L-NIO DIHYDROCHLORIDE

  • ETHYL-L-NIO (HYDROCHLORIDE)
  • L-N5-(1-IMINOBUTYL)ORNITHINE HYDROCHLORIDE
  • DWNWLIPSWIUXRG-FJXQXJEOSA-N
  • chloro (2S)-2-amino-5-(1-aminobutylideneamino)pentanoate
  • EthylLNIO (hydrochloride),Ethyl L NIO (hydrochloride)
  • L-Ornithine, N5-(1-iminobutyl)-, monohydrochloride (9CI)
  • 150403-97-7