Uses
ChemicalBook > CAS DataBase List > 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE

Uses
Product Name
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE
CAS No.
766545-20-4
Chemical Name
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE
Synonyms
2-chloro-5;8-tetrahydro-1;6-naphthyridine hydrochloride;2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HCL;2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-PHTHYRIDINE HYDROCHLORIDE;1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride;2-chloro-5,6,7,8-tetrahydro-1,6-Naphthyridine hydrochloride (1:1);1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1)
CBNumber
CB82457662
Molecular Formula
C8H10Cl2N2
Formula Weight
205.08
MOL File
766545-20-4.mol
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2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C351325
Product name
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridineHydrochloride
Packaging
1g
Price
$130
Updated
2021/12/16
Usbiological
Product number
269796
Product name
2-Chloro-5-
Packaging
2g
Price
$333
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
L14619
Product name
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridinehydrochloride
Purity
97%
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC144167
Product name
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
Packaging
500mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC144167
Product name
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
Packaging
1g
Price
$95
Updated
2021/12/16
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2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1,6-Naphthidine is one of the most widely studied diazanaphthalene compounds. It is a heterocyclic system composed of two aromatic fused rings containing nitrogen heteroatoms, possessing a unique rigid planar structure that exhibits excellent photophysical and photochemical properties. Therefore, it has wide applications in organic light-emitting materials, optoelectronic devices, fluorescent chemical sensors, organic molecular catalysis, and coordination chemistry. With the deepening research on 1,6-naphthidine, derivatives formed by introducing various groups onto the 1,6-naphthidine ring can interact with small biological molecules or metal ions and possess controllable photophysical properties. In particular, some 1,6-naphthidine derivatives exhibit good physiological activity and have been clinically applied in the treatment of certain diseases.

Synthesis

210539-04-1

766545-20-4

The general procedure for the synthesis of 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride from 6-benzyl-2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine was as follows: 6-benzyl-2-chloro-7,8-dihydro-5H-1,6-diazanaphthalene (2.70 g, 10.43 mmol, 1.00 eq.) was dissolved in ethylene chloride (50.00 mL) in dichloroethane (50.00 mL) and 1-chloroethyl carbonyl chloride (2.24 g, 15.65 mmol, 1.50 eq.) was added. The reaction was carried out at 15 °C under nitrogen protection. The reaction mixture was warmed up to 85 °C and the reaction was stirred for 12 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. Methanol (50.00 mL) was added to the residue, heated to 80 °C and stirred for 2 hours. The reaction mixture was cooled and filtered, the filter cake was collected and dried to afford 2-chloro-5,6,7,8-tetrahydro-1,6-diazanaphthalene hydrochloride (2.00 g, 9.75 mmol, 93.50% yield) as a white solid. The resulting product was used directly in the next reaction without further purification.

References

[1] Patent: EP3252059, 2017, A1. Location in patent: Paragraph 0118; 0335-0337
[2] Patent: CN106467537, 2017, A. Location in patent: Paragraph 0151; 0152; 0161; 0162
[3] Patent: CN106467538, 2017, A. Location in patent: Paragraph 0181; 0190; 0191

2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Suppliers

China 127 Germany 1 India 1 United Kingdom 2 United States 12 Global 143
Energy Chemical
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View Lastest Price from 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE 766545-20-4
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22
Career Henan Chemical Co
Product
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE 766545-20-4
Price
US $1.00/g
Min. Order
100g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-23

766545-20-4, 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDERelated Search:

5,6,7,8-TETRAHYDROISOQUINOLINE Nalidixic acid Tetrahydrofurfuryl chloride

  • 2-chloro-5
  • 6-naphthyridine hydrochloride
  • 8-tetrahydro-1
  • 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HCL
  • 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-PHTHYRIDINE HYDROCHLORIDE
  • 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride
  • 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1)
  • 2-chloro-5,6,7,8-tetrahydro-1,6-Naphthyridine hydrochloride (1:1)
  • 766545-20-4
  • C8H9ClN2ClH
  • Heterocycle-Pyridine series