TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE

Product Name: TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE
CAS No.: 169206-67-1
Chemical Name: TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE
Synonyms: SW-90;SWF-90;8-Boc-3-oxo-2,8-diazaspir...;8-Boc-2,8-diazaspiro[4.5]decan-3-one;8-Boc-3-oxo-2,8-diazaspiro[4.5]decane;tert-Butyl 2-oxo-3,8-diazaspiro[4.5]decane-8-carboxylate;TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;2,8-diazaspiro[4.5]decane-8-carboxylic acid, 3-oxo-, 1,1-d;3-Oxo-2,8-diazaspiro[4,5]decane-8-carboxylate tert-butyl ester;3-keto-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
CBNumber: CB82459585
Molecular Formula: C13H22N2O3
Formula Weight: 254.33
MOL File: 169206-67-1.mol

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TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE Property

Boiling point:: 425℃
Density: 1.15
Flash point:: 211℃
storage temp.: 2-8°C
pka: 16.26±0.20(Predicted)
Appearance: White to light yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B694590
Product name: tert-Butyl-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB122793
Product name: tert-Butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Synthonix

Product number: X6098
Product name: 3-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylicacidtert-butylester
Purity: 97.0%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Activate Scientific

Product number: AS51133
Product name: 8-Boc-2,8-diazaspiro[4.5]decan-3-one
Purity: 97+%
Packaging: 250mg
Price: $108
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB122793
Product name: tert-Butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 250mg
Price: $115
Updated: 2021/12/16

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TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate is an organic heterocyclic compound used as a pharmaceutical intermediate. It is used in the synthesis of growth inhibitor receptor 5 (SSTR5) antagonists for the treatment of conditions involving the gut-brain axis.

Synthesis

169206-66-0

169206-67-1

General procedure for the synthesis of tert-butyl 3-oxo-2,8-diazaspiro[4,5]decane-8-carboxylate from tert-butyl 4-(2-methoxy-2-oxoethyl)-4-(nitromethyl)piperidine-1-carboxylate: To a tert-butyl 4-(2-methoxy-2-oxoethyl)-4-(nitromethyl)piperidine-1-carboxylate (1.0 g, 3.2 mmol) ethanol ( 10 mL) solution was added to Raney Ni (1 g). The reaction mixture was stirred under hydrogen atmosphere at 1 atmosphere overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a dichloromethane solution of 10% methanol as eluent to afford the target product tert-butyl 3-oxo-2,8-diazaspiro[4,5]decane-8-carboxylate (694 mg, 86% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD): δ 3.54-3.48 (m, 2H), 3.37-3.32 (m, 2H), 3.23 (s, 2H), 2.26 (s, 2H), 1.62-1.59 (m, 4H), 1.45 (s, 9H).

References

[1] Patent: US2006/19985, 2006, A1. Location in patent: Page/Page column 55
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 19, p. 3772 - 3779
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 3866 - 3874
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 22, p. 6375 - 6378
[5] Patent: WO2015/140559, 2015, A1. Location in patent: Page/Page column 44

TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE Suppliers

China 116 Germany 1 India 1 United Kingdom 2 United States 9 Global 129

PharmaBlock Sciences (Nanjing),Inc.

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Shanghai Boc Chemical Co.,Ltd

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NovoChemy Ltd.

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Shanghai Topbiochem Technology Co., Ltd

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View Lastest Price from TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 169206-67-1
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-05

Career Henan Chemical Co

Product: TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE 169206-67-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-25

169206-67-1, TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATERelated Search:

7-Methoxy-1H,2H,3H,4H,5H-benzo[d]azepine HCl 5-Trifluoromethyl-2H-pyridazine-2-one 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester 1H-Indole-7-carbonitrile,4-fluoro-(9CI) (2-Pyridinyloxy)acetic acid Pyrido[4,3-d]pyrimidin-5(6H)-one, 2,4-dichloro-7,8-dihydro- No Chinese name 5-chloro-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER 8-METHYL-2,8-DIAZASPIRO[4.5]DECAN-3-ONE

TERT-BUTYL 3-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE

2,8-diazaspiro[4.5]decane-8-carboxylic acid, 3-oxo-, 1,1-d

8-Boc-3-oxo-2,8-diazaspir...

8-Boc-3-oxo-2,8-diazaspiro[4.5]decane

2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-,1,1-diMethylethyl ester

3-keto-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

tert-Butyl 2-oxo-3,8-diazaspiro[4.5]decane-8-carboxylate

8-Boc-2,8-diazaspiro[4.5]decan-3-one

SWF-90

SW-90

3-Oxo-2,8-diazaspiro[4,5]decane-8-carboxylate tert-butyl ester

169206-67-1