ChemicalBook > CAS DataBase List > 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE

1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE

Product Name: 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
CAS No.: 259750-61-3
Chemical Name: 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
Synonyms: 4'-Bromo-2'-fluoropropiophenone;1-(4-Bromo-2-fluorophenyl)propanone;1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE;1-(4-Bromo-2-fluorophenyl)-1-propanone;1-Propanone, 1-(4-bromo-2-fluorophenyl)-
CBNumber: CB82459631
Molecular Formula: C9H8BrFO
Formula Weight: 231.06
MOL File: 259750-61-3.mol

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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Property

Boiling point:: 272.2±25.0 °C(Predicted)
Density: 1.463±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B693138
Product name: 1-(4-Bromo-2-fluorophenyl)propan-1-one
Packaging: 250mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V4736
Product name: 1-(4-Bromo-2-fluorophenyl)propan-1-one
Packaging: 1g
Price: $157
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0361942
Product name: 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
Purity: 95.00%
Packaging: 5MG
Price: $498.16
Updated: 2021/12/16

Ambeed

Product number: A153511
Product name: 1-(4-Bromo-2-fluorophenyl)propan-1-one
Purity: 95%
Packaging: 25g
Price: $743
Updated: 2021/12/16

Crysdot

Product number: CD12090727
Product name: 1-(4-Bromo-2-fluorophenyl)propan-1-one
Purity: 95+%
Packaging: 25g
Price: $754
Updated: 2021/12/16

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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Chemical Properties,Usage,Production

Synthesis

1214900-59-0

259750-61-3

General procedure for the synthesis of 1-(4-bromo-2-fluorophenyl)propan-1-one from 1-(4-bromo-2-fluorophenyl)propan-1-ol: To a solution of 1-(4-bromo-2-fluorophenyl)propan-1-ol (5.8 g, 24.89 mmol) in DMF (30 ml) was added pyridinium dichromate (14.04 g, 37.33 mmol) at room temperature. After the reaction was carried out for 12 hours, the reaction mixture was quenched with water, diluted with ethyl acetate and filtered through diatomaceous earth. The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 1-(4-bromo-2-fluorophenyl)propan-1-one as a colorless liquid (4.4 g, 76% yield). The product was confirmed by 1H-NMR (DMSO-d6, 400MHz): δ7.78 (t, J=8.1Hz, 1H), 7.38 (m, 2H), 2.55 (m, 2H), 1.21 (t, J=7.1Hz, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 9, p. 3703 - 3726
[2] Patent: US2011/118257, 2011, A1. Location in patent: Page/Page column 98
[3] Patent: EP2669270, 2013, A1. Location in patent: Paragraph 0816-0817
[4] Journal of Medicinal Chemistry, 2018,

1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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259750-61-3, 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONERelated Search:

1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE

1-(4-Bromo-2-fluorophenyl)propanone

1-Propanone, 1-(4-bromo-2-fluorophenyl)-

1-(4-Bromo-2-fluorophenyl)-1-propanone

4'-Bromo-2'-fluoropropiophenone

259750-61-3