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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE

Product Name
1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
CAS No.
259750-61-3
Chemical Name
1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
Synonyms
4'-Bromo-2'-fluoropropiophenone;1-(4-Bromo-2-fluorophenyl)propanone;1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE;1-(4-Bromo-2-fluorophenyl)-1-propanone;1-Propanone, 1-(4-bromo-2-fluorophenyl)-
CBNumber
CB82459631
Molecular Formula
C9H8BrFO
Formula Weight
231.06
MOL File
259750-61-3.mol
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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Property

Boiling point:
272.2±25.0 °C(Predicted)
Density 
1.463±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B693138
Product name
1-(4-Bromo-2-fluorophenyl)propan-1-one
Packaging
250mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
V4736
Product name
1-(4-Bromo-2-fluorophenyl)propan-1-one
Packaging
1g
Price
$157
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0361942
Product name
1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
Purity
95.00%
Packaging
5MG
Price
$498.16
Updated
2021/12/16
Ambeed
Product number
A153511
Product name
1-(4-Bromo-2-fluorophenyl)propan-1-one
Purity
95%
Packaging
25g
Price
$743
Updated
2021/12/16
Crysdot
Product number
CD12090727
Product name
1-(4-Bromo-2-fluorophenyl)propan-1-one
Purity
95+%
Packaging
25g
Price
$754
Updated
2021/12/16
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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Chemical Properties,Usage,Production

Synthesis

1214900-59-0

259750-61-3

General procedure for the synthesis of 1-(4-bromo-2-fluorophenyl)propan-1-one from 1-(4-bromo-2-fluorophenyl)propan-1-ol: To a solution of 1-(4-bromo-2-fluorophenyl)propan-1-ol (5.8 g, 24.89 mmol) in DMF (30 ml) was added pyridinium dichromate (14.04 g, 37.33 mmol) at room temperature. After the reaction was carried out for 12 hours, the reaction mixture was quenched with water, diluted with ethyl acetate and filtered through diatomaceous earth. The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 1-(4-bromo-2-fluorophenyl)propan-1-one as a colorless liquid (4.4 g, 76% yield). The product was confirmed by 1H-NMR (DMSO-d6, 400MHz): δ7.78 (t, J=8.1Hz, 1H), 7.38 (m, 2H), 2.55 (m, 2H), 1.21 (t, J=7.1Hz, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 9, p. 3703 - 3726
[2] Patent: US2011/118257, 2011, A1. Location in patent: Page/Page column 98
[3] Patent: EP2669270, 2013, A1. Location in patent: Paragraph 0816-0817
[4] Journal of Medicinal Chemistry, 2018,

1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE Suppliers

China 34 India 1 United States 2 Global 37
A.J Chemicals
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Email
sales@ajchem.in
Country
India
ProdList
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259750-61-3, 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONERelated Search:


  • 1-(4-BROMO-2-FLUOROPHENYL)PROPAN-1-ONE
  • 1-(4-Bromo-2-fluorophenyl)propanone
  • 1-Propanone, 1-(4-bromo-2-fluorophenyl)-
  • 1-(4-Bromo-2-fluorophenyl)-1-propanone
  • 4'-Bromo-2'-fluoropropiophenone
  • 259750-61-3