2-(2,2,2-Trifluoroethoxy)phenol
- Product Name
- 2-(2,2,2-Trifluoroethoxy)phenol
- CAS No.
- 160968-99-0
- Chemical Name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Synonyms
- 2-(2,2,2-Trifluoroethoxy)phenol;Phenol, 2-(2,2,2-trifluoroethoxy)-;2,2,2-Trifluoro-2'-hydroxyphenetole
- CBNumber
- CB82462099
- Molecular Formula
- C8H7F3O2
- Formula Weight
- 192.14
- MOL File
- 160968-99-0.mol
2-(2,2,2-Trifluoroethoxy)phenol Property
- Melting point:
- 49-50 ºC
- Boiling point:
- 202 ºC
- Density
- 1.327
- Flash point:
- 102 ºC
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.22±0.30(Predicted)
- color
- Off-White to Pale Grey
Safety
- HS Code
- 2907290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T790190
- Product name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- T790190
- Product name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Packaging
- 25g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 8136AA
- Product name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Packaging
- 25g
- Price
- $226
- Updated
- 2021/12/16
- Product number
- 2607-3-37
- Product name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Packaging
- 5G
- Price
- $395
- Updated
- 2021/12/16
- Product number
- 62313
- Product name
- 2-(2,2,2-Trifluoroethoxy)phenol
- Packaging
- 10g
- Price
- $725
- Updated
- 2021/12/16
2-(2,2,2-Trifluoroethoxy)phenol Chemical Properties,Usage,Production
Uses
2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.
Synthesis
106854-74-4
160968-99-0
GENERAL STEPS: A 1M solution of boron tribromide (30mL, 0.03mol) in dichloromethane was slowly added dropwise to a solution of 1-methoxy-2-(2,2,2-trifluoroethoxy)benzene (4.3g, 0.02mol) in anhydrous dichloromethane (50mL) at -20°C. The reaction was quenched by addition of excess saturated aqueous sodium bicarbonate (40mL). After the reaction mixture was naturally warmed to room temperature, the reaction was quenched by the addition of excess saturated aqueous sodium bicarbonate solution (40 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product obtained was sufficiently pure (98% yield) to be used directly in the subsequent reaction. The product was a yellow oil (3.8 g) and UPLC/MS analysis showed a purity of 99% with a retention time of tR = 5.37 min. molecular formula C8H7F3O2, molecular weight 192.14, single isotope mass 192.04, [M+H]- m/z 191.0. 1H-NMR (300 MHz, CDCl3) δ 4.36 (q, J = 8.4 Hz, 2H, O-CH2-CF3), 6.81-7.11 (m, 4H, Ar-H), 9.72 (br.s., 1H, OH).13C-NMR (75 MHz, CDCl3) δ 56.2, 68.1, 119.2, 121.5, 122.4, 123.7, 126.4, 127.3, 136.4.
References
[1] Molecules, 2018, vol. 23, # 9,
[2] Patent: US5387603, 1995, A
[3] Patent: WO2011/30356, 2011, A2. Location in patent: Page/Page column 23
[4] Patent: WO2011/101864, 2011, A1. Location in patent: Page/Page column 21-22
[5] Patent: US2012/165548, 2012, A1. Location in patent: Page/Page column 11
2-(2,2,2-Trifluoroethoxy)phenol Preparation Products And Raw materials
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View Lastest Price from 2-(2,2,2-Trifluoroethoxy)phenol manufacturers
- Product
- 2-(2,2,2-Trifluoroethoxy)phenol 160968-99-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 694
- Release date
- 2019-09-01