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2-(2,2,2-Trifluoroethoxy)phenol

Product Name
2-(2,2,2-Trifluoroethoxy)phenol
CAS No.
160968-99-0
Chemical Name
2-(2,2,2-Trifluoroethoxy)phenol
Synonyms
2-(2,2,2-Trifluoroethoxy)phenol;Phenol, 2-(2,2,2-trifluoroethoxy)-;2,2,2-Trifluoro-2'-hydroxyphenetole
CBNumber
CB82462099
Molecular Formula
C8H7F3O2
Formula Weight
192.14
MOL File
160968-99-0.mol
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2-(2,2,2-Trifluoroethoxy)phenol Property

Melting point:
49-50 ºC
Boiling point:
202 ºC
Density 
1.327
Flash point:
102 ºC
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.22±0.30(Predicted)
color 
Off-White to Pale Grey
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Safety

HS Code 
2907290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T790190
Product name
2-(2,2,2-Trifluoroethoxy)phenol
Packaging
10g
Price
$225
Updated
2021/12/16
TRC
Product number
T790190
Product name
2-(2,2,2-Trifluoroethoxy)phenol
Packaging
25g
Price
$450
Updated
2021/12/16
AK Scientific
Product number
8136AA
Product name
2-(2,2,2-Trifluoroethoxy)phenol
Packaging
25g
Price
$226
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-37
Product name
2-(2,2,2-Trifluoroethoxy)phenol
Packaging
5G
Price
$395
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
62313
Product name
2-(2,2,2-Trifluoroethoxy)phenol
Packaging
10g
Price
$725
Updated
2021/12/16
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2-(2,2,2-Trifluoroethoxy)phenol Chemical Properties,Usage,Production

Uses

2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.

Synthesis

106854-74-4

160968-99-0

GENERAL STEPS: A 1M solution of boron tribromide (30mL, 0.03mol) in dichloromethane was slowly added dropwise to a solution of 1-methoxy-2-(2,2,2-trifluoroethoxy)benzene (4.3g, 0.02mol) in anhydrous dichloromethane (50mL) at -20°C. The reaction was quenched by addition of excess saturated aqueous sodium bicarbonate (40mL). After the reaction mixture was naturally warmed to room temperature, the reaction was quenched by the addition of excess saturated aqueous sodium bicarbonate solution (40 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product obtained was sufficiently pure (98% yield) to be used directly in the subsequent reaction. The product was a yellow oil (3.8 g) and UPLC/MS analysis showed a purity of 99% with a retention time of tR = 5.37 min. molecular formula C8H7F3O2, molecular weight 192.14, single isotope mass 192.04, [M+H]- m/z 191.0. 1H-NMR (300 MHz, CDCl3) δ 4.36 (q, J = 8.4 Hz, 2H, O-CH2-CF3), 6.81-7.11 (m, 4H, Ar-H), 9.72 (br.s., 1H, OH).13C-NMR (75 MHz, CDCl3) δ 56.2, 68.1, 119.2, 121.5, 122.4, 123.7, 126.4, 127.3, 136.4.

References

[1] Molecules, 2018, vol. 23, # 9,
[2] Patent: US5387603, 1995, A
[3] Patent: WO2011/30356, 2011, A2. Location in patent: Page/Page column 23
[4] Patent: WO2011/101864, 2011, A1. Location in patent: Page/Page column 21-22
[5] Patent: US2012/165548, 2012, A1. Location in patent: Page/Page column 11

2-(2,2,2-Trifluoroethoxy)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2,2,2-Trifluoroethoxy)phenol Suppliers

China 86 India 4 United Kingdom 1 United States 4 Global 95
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
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chenyj@titansci.com
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China
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Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
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chemweiao@163.com
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China
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4378
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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12335
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
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China
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19913
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Beijing Lianben Pharm-Chemicals Tech. Co., Ltd
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+86-10-83386766
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+86-10-83386758
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sales@lianben.com
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China
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Shanghai Huikai Chemical Technology Co., Ltd.
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021-61995394 18916691159
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chemicalsea@163.com
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China
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GIHI CHEMICALS CO.,LTD
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0086-571-86217390
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0086-571-86217391
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Sales@gihichem.com
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China
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860
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Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
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hbeixys2001@163.com
Country
China
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3120
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Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
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39966
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60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
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View Lastest Price from 2-(2,2,2-Trifluoroethoxy)phenol manufacturers

Career Henan Chemical Co
Product
2-(2,2,2-Trifluoroethoxy)phenol 160968-99-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 694
Release date
2019-09-01

160968-99-0, 2-(2,2,2-Trifluoroethoxy)phenolRelated Search:


  • 2-(2,2,2-Trifluoroethoxy)phenol
  • 2,2,2-Trifluoro-2'-hydroxyphenetole
  • Phenol, 2-(2,2,2-trifluoroethoxy)-
  • 160968-99-0