1-METHYLCYCLOPROPANE-1-CARBAMIDE
- Product Name
- 1-METHYLCYCLOPROPANE-1-CARBAMIDE
- CAS No.
- 15910-91-5
- Chemical Name
- 1-METHYLCYCLOPROPANE-1-CARBAMIDE
- Synonyms
- 1-MethylcyclopropanecarboxaMide;1-METHYLCYCLOPROPANE-1-CARBAMIDE;Cyclopropanecarboxamide, 1-methyl-;1-Methyl-cyclopropanecarboxylic acid amide
- CBNumber
- CB82465308
- Molecular Formula
- C5H9NO
- Formula Weight
- 99.13
- MOL File
- 15910-91-5.mol
1-METHYLCYCLOPROPANE-1-CARBAMIDE Property
- Melting point:
- 143-145 °C
- Boiling point:
- 225.3±7.0 °C(Predicted)
- Density
- 1.100±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 16.60±0.20(Predicted)
Safety
- HS Code
- 2924297099
N-Bromosuccinimide Price
- Product number
- M479040
- Product name
- 1-Methylcyclopropanecarboxamide
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0097911
- Product name
- 1-METHYLCYCLOPROPANE-1-CARBAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.93
- Updated
- 2021/12/16
- Product number
- 128702
- Product name
- 1-Methylcyclopropanecarboxamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $1012
- Updated
- 2021/12/16
- Product number
- O34284
- Product name
- 1-Methylcyclopropanecarboxamide
- Purity
- 95%
- Packaging
- 5G
- Price
- $985
- Updated
- 2021/12/16
- Product number
- CD13021489
- Product name
- 1-Methylcyclopropanecarboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $294
- Updated
- 2021/12/16
1-METHYLCYCLOPROPANE-1-CARBAMIDE Chemical Properties,Usage,Production
Synthesis
6914-76-7
15910-91-5
1-Methylcyclopropanecarboxamide was synthesized as follows: 1. In a 1-L four-neck flask equipped with a magnetic stirrer, a dosing funnel, and a nitrogen inlet connected to a water scrubber, a 77.7 wt% toluene solution of 1-methylcyclopropanecarboxylic acid (185.66 g of the solution, containing approximately 144.24 g of 1-methylcyclopropanecarboxylic acid, 1.44 mol) and additional toluene (42 mL) were added. 2. The solution was heated to 45 °C and thionyl chloride (116 mL, 1.58 mol, 1.1 eq.) was added slowly and dropwise over a period of 1 hour. Gas escape and mild heat absorption were observed during the dropwise addition. 3. After the dropwise addition was completed, the reaction mixture was warmed to 80 °C and maintained for 5 hours until GC analysis showed complete consumption of 1-methylcyclopropanecarboxylic acid. 4. In another 2-L three-necked flask equipped with a mechanical stirrer and addition funnel, 28% ammonium hydroxide solution (390 mL, 5.76 mol, 4 eq.) was added. 5. The above thionyl chloride-treated reaction mixture was transferred to a charging funnel and the original reaction flask was washed with a small amount of toluene. 6. The ammonium hydroxide solution was cooled in an ice-acetone bath and the contents of the addition funnel were slowly added over a period of 1 hr, controlling the reaction temperature to no more than 25 °C. The contents of the addition funnel were then mixed with the ammonium hydroxide solution in an ice-acetone bath. 7. After completion of the addition, the mixture was further cooled to 0-5 °C and kept in an ice-water bath for 1 hour. 8. The precipitated 1-methylcyclopropanecarboxamide was collected by filtration, washed with ice water and dried over air to give a white solid product 119.4 g (84% yield) with a melting point of 144-145°C. 1H NMR (DMSO) δ: 7.03 (bs, 1H), 6.83 (bs, 1H), 1.19 (s, 3H), 0.89 (m, 2H), 0.45 (m, 2H).
References
[1] Journal of the American Chemical Society, 1961, vol. 83, p. 2719 - 2724
[2] Journal of Organic Chemistry, 1989, vol. 54, # 8, p. 1815 - 1820
[3] Patent: US2002/16493, 2002, A1
[4] Patent: US2012/22039, 2012, A1. Location in patent: Page/Page column 64
[5] Patent: US2014/275080, 2014, A1. Location in patent: Paragraph 0385
1-METHYLCYCLOPROPANE-1-CARBAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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