2-(Hydroxymethyl)isonicotinic acid
- Product Name
- 2-(Hydroxymethyl)isonicotinic acid
- CAS No.
- 915140-06-6
- Chemical Name
- 2-(Hydroxymethyl)isonicotinic acid
- Synonyms
- 2-Hydroxymethylisonicotinic acid;2-(hydroxymethyl)-4-pyridinecarboxylic acid;4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-
- CBNumber
- CB82468677
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 915140-06-6.mol
2-(Hydroxymethyl)isonicotinic acid Property
- Boiling point:
- 478.4±35.0 °C(Predicted)
- Density
- 1.404
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.95±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0388281
- Product name
- 2-(HYDROXYMETHYL)ISONICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.45
- Updated
- 2021/12/16
- Product number
- 35932
- Product name
- 2-(Hydroxymethyl)isonicotinicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $880
- Updated
- 2021/12/16
- Product number
- CM178301
- Product name
- 2-(Hydroxymethyl)isonicotinicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $1122
- Updated
- 2021/12/16
- Product number
- CM178301
- Product name
- 2-(Hydroxymethyl)isonicotinicacid
- Purity
- 95%
- Packaging
- 10g
- Price
- $1683
- Updated
- 2021/12/16
- Product number
- CM178301
- Product name
- 2-(Hydroxymethyl)isonicotinicacid
- Purity
- 95%
- Packaging
- 25g
- Price
- $2992
- Updated
- 2021/12/16
2-(Hydroxymethyl)isonicotinic acid Chemical Properties,Usage,Production
Synthesis
Ethyl 2-(hydroxymethyl)isonicotinate (iso-EhmnH) (4.84 g, 26.7 mmol) was dissolved in THF/H2O (40 mL, v:v = 1:1). KOH (4.58 g, 81.6 mmol, 3 eq.) was added as solid and the mixture stirred at 100 °C for 20 h and then cooled to r.t. The mixture was further cooled in ice-water and then HNO3 added to adjust the pH to 4–5. The solvent was removed under vacuum. The organic part in the solid mixture was then extracted twice with 400 mL of ethanol and the solvent removed. The powder contains inorganic material was added in hot isopropanol and then filtered, evaporation of iso-propanol yielded iso-hmnH2 as white powder. Yield 2.93 g, 72%[1].
References
[1] Armaghan M, et al. Isolation of first row transition metal–carboxylate zwitterions. RSC Advances, 2015; 5: 42978-42989.