4-Bromo-2-(trifluoromethoxy)benzoic acid
- Product Name
- 4-Bromo-2-(trifluoromethoxy)benzoic acid
- CAS No.
- 509142-48-7
- Chemical Name
- 4-Bromo-2-(trifluoromethoxy)benzoic acid
- Synonyms
- 4-Bromo-2-(trifluoromethoxy)benzoic acid;Benzoic acid, 4-bromo-2-(trifluoromethoxy)-
- CBNumber
- CB82470124
- Molecular Formula
- C8H4BrF3O3
- Formula Weight
- 285.01
- MOL File
- 509142-48-7.mol
4-Bromo-2-(trifluoromethoxy)benzoic acid Property
- Melting point:
- 91～94℃
- Boiling point:
- 272.7±40.0 °C(Predicted)
- Density
- 1.797±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.69±0.36(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B695198
- Product name
- 4-Bromo-2-(trifluoromethoxy)benzoicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B695198
- Product name
- 4-Bromo-2-(trifluoromethoxy)benzoicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0070344
- Product name
- 4-BROMO-2-(TRIFLUOROMETHOXY)BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $680.3
- Updated
- 2021/12/16
- Product number
- 058518
- Product name
- 4-Bromo-2-(trifluoromethoxy)benzoic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 2621-B-0B
- Product name
- 4-Bromo-2-(trifluoromethoxy)benzoic acid
- Packaging
- 25g
- Price
- $234
- Updated
- 2021/12/16
4-Bromo-2-(trifluoromethoxy)benzoic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Synthesis
288315-03-7
122-01-0
509142-48-7
GENERAL STEPS: Example 63 (a) Synthesis of 4-bromo-2-(trifluoromethoxy)benzoic acid Thionyl chloride (5 mL) was added to 4-chlorobenzoic acid (0.49 g, 3.1 mmol). After addition of 2 drops of anhydrous DMF, the reaction mixture was refluxed under nitrogen protection for about 15 min. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was dissolved in dichloromethane (5 mL). Subsequently, 3,3-difluoroazetidine hydrochloride (0.42 g, 3.3 mmol) and triethylamine (0.91 mL, 6.6 mmol) were added. The reaction mixture was stirred at room temperature for about 15 minutes. The reaction solution was diluted with dichloromethane and washed sequentially with saturated aqueous sodium bicarbonate solution and water. The organic phase was treated with anhydrous ethanol (until a clarified solution was obtained) and the solvent was evaporated in vacuum to give 4-bromo-2-trifluoromethoxybenzoic acid as a solid in 94% yield. The resulting product could be used in the next reaction without further purification. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.75-7.66 (m, 2H), 7.58-7.48 (m, 2H), 5.06-4.15 (m, 4H); MS (ESI) m/z 232 (M + 1).
References
[1] Patent: WO2007/40440, 2007, A1. Location in patent: Page/Page column 115-116
4-Bromo-2-(trifluoromethoxy)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-(trifluoromethoxy)benzoic acid manufacturers
- Product
- 4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 4-Bromo-2-(trifluoromethoxy)benzoic acid 509142-48-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25